Triclabendazole is a benzimidazole derivative that shows anthelminthic activity against Fasciola and Paragonimus[3]. Triclabendazole at 5μM partially protected yeast cells from sugar-induced cell death as shown by increased mean survival time compared to the control group (0.9±0.3d vs. 0.3±0.1d). It also reversed α-synuclein-induced cell death in yeast cells. Pretreatment with 50μM triclabendazole protected rat PC12 cells from H2O2-induced death[4]. Administration of triclabendazole at a dose of 400 mg/kg resulted in a worm burden reduction of < 10% in mice infected with a Liberian strain of S. mansoni[5].
作用机制
Triclabendazole is an anthelminthic and its mechanism of action may involve tegumental disruption via inhibiting microtubule-based processes or adenylate cyclase activity[3].
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