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首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 / 前列腺素受体 / Travoprost/曲伏前列素

Travoprost/曲伏前列素 {[allProObj[0].p_purity_real_show]}

货号：A465015 同义名： Fluprostenol isopropyl ester; AL6221

Travoprost is a synthetic prostaglandin F2α analog as a potent and selective FP prostaglandin receptor agonist, used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure.

Travoprost/曲伏前列素 化学结构 CAS号：157283-68-6
Travoprost/曲伏前列素 化学结构
CAS号：157283-68-6
Travoprost/曲伏前列素 3D分子结构
CAS号：157283-68-6
Travoprost/曲伏前列素 化学结构 CAS号：157283-68-6
Travoprost/曲伏前列素 3D分子结构 CAS号：157283-68-6
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Travoprost/曲伏前列素 纯度/质量文件 产品仅供科研

货号：A465015 标准纯度： {[allProObj[0].p_purity_real_show]}
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Travoprost/曲伏前列素 生物活性

描述 Prostaglandin (PG) F(2α) is widely distributed in various organs and exhibits various biological functions, such as luteolysis, parturition, aqueous humor homeostasis, vasoconstriction, rennin secretion, pulmonary fibrosis[3]. Travoprost, a highly selective and potent analogue of the prostaglandin PGF(2α), has recently been approved and marketed as a topical ocular hypotensive agent for the treatment of ocular hypertension and glaucoma [4]. Travoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0. 01, 0. 03 and 0.1 μg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg[5]. As assessed with YO-PRO-1 and Hoechst 33342 relative to cell viability determined with NR or AB, travoprost/timolol PQ produced significantly less apoptosis than travoprost/timolol BAK and latanoprost/timolol BAK and their respective BAK concentrations alone (P<0. 0001 for all) [6].

Travoprost/曲伏前列素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00767481 Glaucoma Ocul... 展开 >>ar Hypertension 收起 << Phase 3 Terminated(Project Cancelled) - Mexico ... 展开 >> Mexico City, Mexico, 6700 收起 <<
NCT01253902 Glaucoma, Open-Angle ... 展开 >> Ocular Hypertension 收起 << Phase 4 Completed - United States, Arkansas ... 展开 >> Rogers, Arkansas, United States Canada, Alberta Calgary, Alberta, Canada 收起 <<
NCT01253902 - Completed - -

Travoprost/曲伏前列素 参考文献

[1]Berdahl J, Voskanyan L, et al. Implantation of two second-generation trabecular micro-bypass stents and topical travoprost in open-angle glaucoma not controlled on two preoperative medications: 18-month follow-up. Clin Exp Ophthalmol. 2017 Nov;45(8):797-802.

[2]Kiddee W, Atthavuttisilp S. The effects of selective laser trabeculoplasty and travoprost on circadian intraocular pressure fluctuations: A randomized clinical trial. Medicine (Baltimore). 2017 Feb;96(6):e6047.

[3]Kikuko Watanabe. Recent reports about enzymes related to the synthesis of prostaglandin (PG) F(2) (PGF(2α) and 9α, 11β-PGF(2)). J Biochem. 2011 Dec;150(6):593-6.

[4]Jess T Whitson. Travoprost--a new prostaglandin analogue for the treatment of glaucoma. Expert Opin Pharmacother. 2002 Jul;3(7):965-77.

[5] M R Hellberg, et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther. 2001 Oct;17(5):421-32.

[6]Françoise Brignole-Baudouin, Luisa Riancho,et al. In vitro comparative toxicology of polyquad-preserved and benzalkonium chloride-preserved travoprost/timolol fixed combination and latanoprost/timolol fixed combination. J Ocul Pharmacol Ther. 2011 Jun;27(3):273-80.

Travoprost/曲伏前列素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.00mL

0.40mL

0.20mL

9.99mL

2.00mL

1.00mL

19.98mL

4.00mL

2.00mL

Travoprost/曲伏前列素 技术信息

CAS号157283-68-6
分子式C26H35F3O6
分子量 500.55
SMILES Code O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)[C@H](O)C[C@@H]1O
MDL No. MFCD03411995
别名 Fluprostenol isopropyl ester; AL6221; Travoprost, AL-6221, Travatan, Travoprostin; Travoprostum; Flu-Ipr
运输蓝冰
InChI Key MKPLKVHSHYCHOC-AHTXBMBWSA-N
Pubchem ID 5282226
存储条件

In solvent -20°C:3-6个月-80°C:12个月
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Travoprost | 157283-68-6 | Fluprostenol isopropyl ester | AL6221 | Flu-Ipr | AL6221 | AL 6221 | AL-6221 | FP Prostaglandin Receptor Agonist | GPCR/G Protein | Prostaglandin Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Travoprost/曲伏前列素 纯度/质量文件 | Travoprost/曲伏前列素 生物活性 | Travoprost/曲伏前列素 临床数据 | Travoprost/曲伏前列素 参考文献 | Travoprost/曲伏前列素 实验方案 | Travoprost/曲伏前列素 技术信息

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