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Tranylcypromine hemisulfate {[allProObj[0].p_purity_real_show]}

货号:A354034 同义名: 反式-2-苯基环丙胺 半硫酸盐 / SKF 385 hemisulfate; Parnate

Tranylcypromine hemisulfate is an inhibitor of monoamine oxidase (MAO) and prostacyclin synthase, potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50 < 2 μM for BHC110/LSD1).

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Tranylcypromine hemisulfate 化学结构 CAS号:13492-01-8
Tranylcypromine hemisulfate 化学结构
CAS号:13492-01-8
Tranylcypromine hemisulfate 3D分子结构
CAS号:13492-01-8
Tranylcypromine hemisulfate 化学结构 CAS号:13492-01-8
Tranylcypromine hemisulfate 3D分子结构 CAS号:13492-01-8
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Tranylcypromine hemisulfate 纯度/质量文件 产品仅供科研

货号:A354034 标准纯度: {[allProObj[0].p_purity_real_show]}
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Tranylcypromine HCl +++

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Tranylcypromine hemisulfate 生物活性

描述 Tranylcypromine hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. TCP (Tranylcypromine) significantly prevented Aβ-induced neuronal death in a concentration-dependent fashion and was maximally protective only at 10 µM. TCP-But was maximally protective in mixed neuronal cultures at 1 µM, a lower concentration compared to TCP, whereas the new derivative, TCP-Ac(TCP acetamide), was more efficacious than TCP and TCP-But (TCP butyramide) and significantly protected cortical neurons against Aβ toxicity at nanomolar concentrations (100 nM)[3]. TC (tranylcypromine) treatment significantly and substantially reduced the lesion size and improved generalized hyperalgesia in a dose-dependent fashion in mice with induced endometriosis. In addition, TC treatment resulted in reduced immunoreactivity to biomarkers of proliferation, angiogenesis, and H3K4 methylation, leading to arrested EMT (epithelial-mesenchymal transition) and lesion growth[4]. Tranylcypromine (100 μM) significantly protects RGCs (retinal ganglion cell) from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress. Besides, tranylcypromine contributes to RGC survival via alterations of p38 MAPKγ activity. Tranylcypromine (500 mM) injection exerts neuroprotective effects within intracellular apoptotic signaling pathways and suppresses morphologic changes in the retina of the rat, suppresses caspase 3 activity and recovers p38 MAPKγ expression in the retina after NMDA-induced injury, and enhances RGC survival after retinal injury via the attenuation of NMDA neurotoxicity[5].

Tranylcypromine hemisulfate 参考文献

[1]Sun Q, Ding D, et al. Tranylcypromine, a lysine-specific demethylase 1(LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Reprod Biol Endocrinol. 2016 Apr 9;14:17.

[2]Caraci F, Pappalardo G, et al. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity. Eur J Pharmacol. 2015 Oct 5;764:256-63.

[3]Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity. Eur J Pharmacol. 2015 Oct 5;764:256-263

[4]Sun Q, Ding D, Liu X, Guo SW. Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Reprod Biol Endocrinol. 2016 Apr 9;14:17

[5]Tsutsumi T, Iwao K, Hayashi H, Kirihara T, Kawaji T, Inoue T, Hino S, Nakao M, Tanihara H. Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6461-6473

Tranylcypromine hemisulfate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.72mL

2.74mL

1.37mL

27.44mL

5.49mL

2.74mL

Tranylcypromine hemisulfate 技术信息

CAS号13492-01-8
分子式C18H24N2O4S
分子量 364.46
SMILES Code N[C@H]1[C@H](C2=CC=CC=C2)C1.O=S(O)(O)=O.N[C@H]3[C@H](C4=CC=CC=C4)C3
MDL No. MFCD00079222
别名 反式-2-苯基环丙胺 半硫酸盐 ;SKF 385 hemisulfate; Parnate; Tranylcypromine Sulfate; Tranylcypromine(hemisulfate)
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, room temperature

溶解方案 配制的工作液建议现用现配,短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
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