Tirapazamine/替拉扎明
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货号：A680596
同义名：
Tirazone; Win59075
Tirapazamine is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen.
Tirapazamine/替拉扎明 化学结构
Tirapazamine/替拉扎明 3D分子结构
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Tirapazamine/替拉扎明 纯度/质量文件 产品仅供科研
货号：A680596
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Tirapazamine/替拉扎明 质控信息
Tirapazamine/替拉扎明 生物活性
描述
Tirapazamine is a novel bioreductive agent with selective cytotoxicity to hypoxic tumour cells, irrespective of their p53 status or apoptotic response, and acts synergistically with cisplatin[3] [4] [5] [6] [7]
Tirapazamine/替拉扎明 参考文献
[1] Cai TY, Liu XW, et al. Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase I inhibitors via cooperative modulation of hypoxia-inducible factor-1α. Mol Cancer Ther. 2014 Mar;13(3):630-42.
[2] Sliwinska J, Dudka J, et al. Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca²⁺ balance protein levels. Oxid Med Cell Longev. 2012;2012:890826.
[3] Brown JM. Exploiting tumour hypoxia and overcoming mutant p53 with tirapazamine. Br J Cancer. 1998 Jun;77 Suppl 4(Suppl 4):12-4
[4] Gatzemeier U, Rodriguez G, Treat J, Miller V, von Roemeling R, Viallet J, Rey A. Tirapazamine-cisplatin: the synergy. Br J Cancer. 1998 Jun;77 Suppl 4(Suppl 4):15-7
[5] Cai TY, Liu XW, Zhu H, Cao J, Zhang J, Ding L, Lou JS, He QJ, Yang B. Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase I inhibitors via cooperative modulation of hypoxia-inducible factor-1α. Mol Cancer Ther. 2014 Mar;13(3):630-42
[6] Sliwinska J, Dudka J, Korga A, Burdan F, Matysiak W, Jodlowska-Jedrych B, Mandziuk S, Dawidek-Pietryka K. Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca²⁺ balance protein levels. Oxid Med Cell Longev. 2012;2012:890826
[7] Siim BG, van Zijl PL, Brown JM. Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro. Br J Cancer. 1996 Apr;73(8):952-60
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Tirapazamine/替拉扎明 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
5.61mL
1.12mL
0.56mL
28.07mL
5.61mL
2.81mL
56.13mL
11.23mL
5.61mL
Tirapazamine/替拉扎明 技术信息
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