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首页 / 抑制剂/激动剂 / 神经信号通路 / AChR / Tiotropium Bromide/噻托溴铵

Tiotropium Bromide/噻托溴铵 {[allProObj[0].p_purity_real_show]}

货号：A166270 同义名： BA679 BR; Tiotropium (bromide)

Tiotropium bromide is amAChR antagonist which acts through blocking the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Tiotropium Bromide/噻托溴铵 化学结构 CAS号：136310-93-5
Tiotropium Bromide/噻托溴铵 化学结构
CAS号：136310-93-5
Tiotropium Bromide/噻托溴铵 3D分子结构
CAS号：136310-93-5
Tiotropium Bromide/噻托溴铵 化学结构 CAS号：136310-93-5
Tiotropium Bromide/噻托溴铵 3D分子结构 CAS号：136310-93-5
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Tiotropium Bromide/噻托溴铵 纯度/质量文件 产品仅供科研

货号：A166270 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		95%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 97%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 99%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine HCl ✔ 99%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 99%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		99%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M2 mAChR, Ki: 0.1 nM

M4 mAChR, Ki: 0.21 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Tiotropium Bromide/噻托溴铵 生物活性

描述 Tiotropium bromide, a new long-lasting anticholinergic drug, binds with high affinity to muscarinic receptors but dissociates very slowly from M(1)- and M(3)-muscarinic receptors. Tiotropium bromide will become the most widely used bronchodilator for COPD (chronic obstructive pulmonary disease) patients in the future[3]. Moreover, Tiotropium inhalation attenuates RB-induced (Resistive breathing) pulmonary inflammation[4]. Tiotropium bromide at >15 pg/mL inhibited IL-8 production from both BEAS-2B cells and LFs (lung fibroblasts) after LPS stimulation, and thus may contribute to lower cellular inflammation in COPD[5].

Tiotropium Bromide/噻托溴铵 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01257230 Asthma Phase 3 Completed - -
NCT02039011 Asthma Phase 4 Completed - United Kingdom ... 展开 >> Asthma and Allergy Research Group, University of Dundee Dundee, United Kingdom, DD1 3AU 收起 <<
NCT00949975 Chronic Obstructive Pulmonary ... 展开 >>Disease 收起 << Phase 2 Completed - -

Tiotropium Bromide/噻托溴铵 参考文献

[1]Brandt C, Thronicke A, et al. Impact of Long-Term Tiotropium Bromide Therapy on Annual Lung Function Decline in Adult Patients with Cystic Fibrosis. PLoS One. 2016 Jun 28;11(6):e0158193.

[2]Barnes PJ, Belvisi MG, Mak JC, Haddad EB, O'Connor B. Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease. Life Sci. 1995;56(11-12):853-9.

[3]Barnes PJ. Tiotropium bromide. Expert Opin Investig Drugs. 2001 Apr;10(4):733-40. doi: 10.1517/13543784.10.4.733. PMID: 11281822.

[4]Toumpanakis D, Loverdos K, Tzouda V, Vassilakopoulou V, Litsiou E, Magkou C, Karavana V, Pieper M, Vassilakopoulos T. Tiotropium bromide exerts anti-inflammatory effects during resistive breathing, an experimental model of severe airway obstruction. Int J Chron Obstruct Pulmon Dis. 2017 Jul 28;12:2207-2220. doi: 10.2147/COPD.S137587. PMID: 28814849; PMCID: PMC5546183.

[5]Suzaki I, Asano K, Shikama Y, Hamasaki T, Kanei A, Suzaki H. Suppression of IL-8 production from airway cells by tiotropium bromide in vitro. Int J Chron Obstruct Pulmon Dis. 2011;6:439-48. doi: 10.2147/COPD.S23695. Epub 2011 Sep 6. PMID: 22003289; PMCID: PMC3186742.

Tiotropium Bromide/噻托溴铵 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.58mL

2.12mL

1.06mL

21.17mL

4.23mL

2.12mL

Tiotropium Bromide/噻托溴铵 技术信息

CAS号136310-93-5
分子式C19H22BrNO4S2
分子量 472.42
SMILES Code C[N+]1(C)[C@@]2([H])[C@@]3([H])O[C@@]3([H])[C@]1([H])C[C@H](OC(C(C4=CC=CS4)(O)C5=CC=CS5)=O)C2.[Br-]
MDL No. MFCD00867027
别名 BA679 BR; Tiotropium (bromide)
运输蓝冰
InChI Key DQHNAVOVODVIMG-RGECMCKFSA-M
Pubchem ID 5487426
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, 2-8°C

Tags: Tiotropium | 136310-93-5 | BA679 BR | mAChR | mAChR Antagonist | GPCR/G Protein | Neuronal Signaling | mAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Tiotropium Bromide/噻托溴铵 纯度/质量文件 | Tiotropium Bromide/噻托溴铵 亚型比较 | Tiotropium Bromide/噻托溴铵 生物活性 | Tiotropium Bromide/噻托溴铵 临床数据 | Tiotropium Bromide/噻托溴铵 参考文献 | Tiotropium Bromide/噻托溴铵 实验方案 | Tiotropium Bromide/噻托溴铵 技术信息

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