Tiopronin, derivative of glycine, is used to control the rate of cystine precipitation and excretion. It can be used as an antioxidant agent and radical scavenger.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Tiopronin, known for its multifaceted therapeutic roles, functions as a diffusible antioxidant, an antidote to heavy metal poisoning, and a radioprotective agent. It effectively manages the rate of cystine precipitation and excretion, showing promise in the treatment of cystinuria, rheumatoid arthritis, and hepatic disorders[1].[2].
Tiopronin/硫普罗宁 动物研究
Animal study
In medical studies, Tiopronin (NMPG) has been shown to mitigate colonic injury and significantly reduce myeloperoxidase activity, a key indicator of inflammation. Additionally, NMPG substantially lowers the expression of pro-inflammatory mediators in the inflamed colon. It induces hypoxia-inducible factor-1α (HIF-1α) in human colon carcinoma cells, which enhances the secretion of vascular endothelial growth factor (VEGF), crucial for the healing of gastrointestinal mucosal ulcers. This induction of HIF-1α by NMPG occurs through the inhibition of HIF prolyl hydroxylase-2 (HPH-2), a crucial enzyme in the negative regulation of HIF-1α stability[2].
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