Tilmicosin is a widely used antibiotic in veterinary applications. Its antimicrobial activity is ranged from Gram-positive and some Gram-negative bacteria towards activities against Mycoplasma and Chlamydia[3]. The MIC90 of tilmicosin against Haemophilus parasuis, Actinbacillus pleuropneumoniae, and Pasteurella multocida were all 8 μg/ml. The relative bioavailability of tilmicosin enteric granules to premix was 114.97 ± 7.19%, according to the AUC0-t values[4]. Tilmicosin is used to treat intramammary infections against Staphylococcus aureus and has clinical anti-inflammatory effects. Tilmicosin decreases intracellular infection and had a protective effect on MAC-T (immortalized mammary epithelial cells) reducing apoptosis after infection by 80%. Furthermore, tilmicosin reduced reactive oxygen species (ROS), IL-1β, IL-6, and TNF-αproduction. The anti-inflammatory effect of tilmicosin helped to preserve casein synthesis in mammary epithelial cells[5].
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