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Tetrahydropalmatine/延胡索乙素
Tetrahydropalmatine/延胡索乙素
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货号：A482970
同义名：
四氢帕马丁
/ DL-Tetrahydropalmatine
Tetrahydropalmatine is an isoquinoline alkaloid mainly found in the genus Corydalis with analgesic effects. It antagonizes dopamine D1, and D2 receptors as well as actions at dopamine D3, alpha adrenergic and serotonin receptors, with Ki values of 124 nM and 388 nM for D1 and D2 dopamine receptors, respectively.
Tetrahydropalmatine/延胡索乙素 化学结构
Tetrahydropalmatine/延胡索乙素 3D分子结构
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Tetrahydropalmatine/延胡索乙素 纯度/质量文件 产品仅供科研
货号：A482970
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Tetrahydropalmatine/延胡索乙素 质控信息
Penfluridol
+
Dopamine receptor, Ki: 1.6 μM
98%
Ansofaxine HCl
++
Dopamine receptor, IC50: 491 nM
99%
Tetrahydroberberine
+
98+%
Prochlorperazine Maleate
✔
98% (HPLC)
Olanzapine
✔
99+%
Trifluoperazine
++++
Dopamine D2 receptor, IC50: 1.1 nM
98%
Ropinirole HCl
++
99%
Lurasidone
++++
98%
Levosulpiride
✔
99+%
Pridopidine
✔
95%
Metoclopramide
✔
✔
99+%
Molindone HCl
✔
99%
Sulpiride
✔
99+%
Perospirone
++++
99%
Perospirone HCl
++++
99%
Phenothiazine
✔
98%
Pimozide
+
Dopamine D1 receptor, Ki: 6600 nM
+++
Dopamine D2 receptor, Ki: 3.0 nM
++++
Dopamine D3 receptor, Ki: 0.83 nM
98%
Rotundine
++
D1 receptor, IC50: 166 nM
+
D2 receptor, IC50: 1.47 μM
+
D3 receptor, IC50: 3.25 μM
98%
Domperidone
✔
99+%
ONC206
✔
99%
Pimethixene maleate
++
Dopamine D1 Receptor, pKi: 6.37
+++
Dopamine D2 Receptor, pKi: 8.19
++
Dopamine D4.4 Receptor, pKi: 7.54
97%
Loxapine succinate
++
D2 receptor (Human), Ki: 62 nM
D1 receptor (human), Ki: 26 nM
++
D2 receptor (human), Ki: 24 nM
D2 receptor (bovine), Ki: 26 nM
+++
D4 receptor (human), Ki: 7.5 nM
98%
Chlorprothixene
+++
+++
+++
+++
99%
SCH-23390 HCl
++++
D1 dopamine receptor, Ki: 0.2 nM
++++
D5 dopamine receptor, Ki: 0.3 nM
98%
MPP+ iodide
✔
97%
σ1 Receptor antagonist-1
+
97%
Benztropine mesylate
++
98%
Azaperone
✔
98%
Ziprasidone HCl
✔
98+%
Paliperidone
✔
98%
Alizapride HCl
✔
99+%
Amisulpride
✔
98%
Quetiapine hemifumarate
✔
Adrenergic Receptor
98%
Clozapine N-oxide
✔
99%
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Tetrahydropalmatine/延胡索乙素 生物活性
描述
Tetrahydropalmatine, one of the active components of rhizoma corydalis, exert several pharmacological effects, including anti-inflammatory, anti-tumor and analgesic activities. Tetrahydropalmatine did not exhibit any cellular toxicity up to 40 µM. Tetrahydropalmatine suppress lipid accumulation in 3T3-L1 cells and it inhibited pre-adipocyte differentiation in a concentration-dependent manner[3] [4]
Tetrahydropalmatine/延胡索乙素 参考文献
[1] Zhang X, Guan J, et al. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:126-32.
[2] Lin YY, Wang YP, et al. Plasma pharmacokinetics and lung distribution of tetrahydropalmatine after topical application of cold asthma recipe extract: Feishu (BL 13) versus Non-Feishu acupoint. J Ethnopharmacol. 2014 Apr 28;153(2):454-60.
[3] Piao GC, Liu GC, Jin XJ, Jin D, Yuan HD. Tetrahydropalmatine inhibits lipid accumulation through AMPK signaling pathway in 3T3‑L1 adipocytes. Mol Med Rep. 2017 Jun;15(6):3912-3918. doi: 10.3892/mmr.2017.6473. Epub 2017 Apr 12. PMID: 28440456.
[4] Ben Khelil M, Kamel M, Lahmar S, Mrabet A, Borsali Falfoul N, Hamdoun M. Death certificate accuracy in a Tunisian Emergency Department. Tunis Med. 2017 Jun;95(6):422-428. PMID: 29512798.
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Tetrahydropalmatine/延胡索乙素 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.81mL
0.56mL
0.28mL
14.07mL
2.81mL
1.41mL
28.13mL
5.63mL
2.81mL
Tetrahydropalmatine/延胡索乙素 技术信息
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