TCS JNK 5a
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货号：A222483
同义名：
JNK Inhibitor IX; c-Jun N-terminal Kinase Inhibitor IX
JNK Inhibitor IX can selectively inhibit JNK2 and JNK3 through targeting the ATP binding site with pIC50 of 6.5 and 6.7, respectively.
TCS JNK 5a 化学结构
TCS JNK 5a 3D分子结构
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TCS JNK 5a 纯度/质量文件 产品仅供科研
货号：A222483
标准纯度：
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TCS JNK 5a 质控信息
Mulberroside A
✔
99%+
Loureirin B
✔
Potassium Channel,Calcium Channel
99%+
Ginsenoside Re
✔
NF-κB
98%
(+)-(3R,8S)-Falcarindiol
✔
ERK,STAT
99%+
trans-Zeatin
✔
p38 MAPK,ERK
95+%
Urolithin B
✔
ERK,NF-κB
95%
Cucurbitacin IIb
✔
NF-κB
99%
Astragaloside IV
✔
Akt,NF-κB,mTOR
98%
m-PEG25-NHS ester
✔
95%
NDMC101
✔
99%+
DB07268
++++
99%+
SP600125
+
+++
+++
+++
98%
JNK-IN-7
++++
++++
++++
99%
JNK-IN-8
++++
+++
++++
99%+
3,3',5-Triiodo-L-thyronine
++
++
+++
98%
IQ-1S free acid
+
++
+++
99%
BI-78D3
++
++
++
++
99%+
Bentamapimod
+++
+++
++
98%
Resveratrol
+
98%
Indirubin-3′-oxime
✔
99%+
SU3327
+
+
+
+
99%+
JNK Inhibitor VIII
++++
JNK1, IC50: 45 nM
JNK1, Ki: 2 nM
++++
JNK2, Ki: 4 nM
JNK2, IC50: 160 nM
+++
98%
Doramapimod
✔
99%+
RPI-1
✔
99%
TCS JNK 5a
++
++
98%
SP 600125, negative control
+
+
97%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
TCS JNK 5a 生物活性
靶点
JNK2
JNK2, pIC50:6.5
JNK2
JNK2, pIC50:6.5
JNK3
JNK3, pIC50:6.7
JNK3
JNK3, pIC50:6.7
描述
c-Jun N-terminal kinase (JNK) is implicated in various human diseases, including cancer, inflammatory disorders, and neurodegeneration. JNK inhibitor IX is a potent JNK inhibitor with pIC50 values of 6.5 and 6.7 for JNK2 and JNK3, respectively[3] [4] [5]
作用机制
JNK inhibitor IX is a potent, ATP-competitive inhibitor of both JNK2 and JNK3[3]
TCS JNK 5a 参考文献
[1] Rudolf E, Cervinka M. Trivalent chromium activates Rac-1 and Src and induces switch in the cell death mode in human dermal fibroblasts. Toxicol Lett. 2009 Aug 10;188(3):236-42.
[2] Angell RM, Atkinson FL, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.
[3] Angell RM, Atkinson FL, Brown MJ, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007;17(5):1296-1301. doi:10.1016/j.bmcl.2006.12.003
[4] Rudolf E, Cervinka M. Trivalent chromium activates Rac-1 and Src and induces switch in the cell death mode in human dermal fibroblasts. Toxicol Lett. 2009;188(3):236-242. doi:10.1016/j.toxlet.2009.04.019
[5] Mancini M, Veljkovic N, Corradi V, et al. 14-3-3 ligand prevents nuclear import of c-ABL protein in chronic myeloid leukemia. Traffic. 2009;10(6):637-647. doi:10.1111/j.1600-0854.2009.00897.x
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TCS JNK 5a 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.01mL
0.60mL
0.30mL
15.04mL
3.01mL
1.50mL
30.08mL
6.02mL
3.01mL
TCS JNK 5a 技术信息
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