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Sulindac sulfone/舒林酸砜 {[allProObj[0].p_purity_real_show]}

货号:A1161164

Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.

Sulindac sulfone/舒林酸砜 化学结构 CAS号:59973-80-7
Sulindac sulfone/舒林酸砜 化学结构
CAS号:59973-80-7
Sulindac sulfone/舒林酸砜 3D分子结构
CAS号:59973-80-7
Sulindac sulfone/舒林酸砜 化学结构 CAS号:59973-80-7
Sulindac sulfone/舒林酸砜 3D分子结构 CAS号:59973-80-7
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Sulindac sulfone/舒林酸砜 纯度/质量文件 产品仅供科研

货号:A1161164 标准纯度: {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

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产品名称 COX COX-1 COX-2 其他靶点 纯度
Piroxicam 98%
Salicylic acid 98%
Phenacetin 98%
Etodolac 99%
Flunixin meglumine 98%
Ibuprofen L-lysine 99%
Nabumetone 98%
Acemetacin 98%
Diflunisal 98%
Pranoprofen 98%
Ampiroxicam 98%
Meloxicam 98%
Sulindac 98%
Ketoprofen 98%
Mefenamic Acid 95%
Bromfenac sodium 98%
Oxaprozin 99%
Aspirin 99%
Nepafenac 98%
Zaltoprofen 99%
Salicin 98%
Suprofen 99%+
Xanthohumol 99%
Parecoxib 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

98%
Etoricoxib 99%
Niflumic Acid 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

99+%
Ibuprofen +

COX-1, IC50: 13 μM

+

COX-2, IC50: 370 μM

98%
Indomethacin ++

COX1, IC50: 0.28 μM

+

COX-2, IC50: 14 μM

97%
Lornoxicam ++++

COX-1, IC50: 5 nM

++++

COX-2, IC50: 8 nM

98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

+++

COX-2, IC50: 50 nM

99%
Rofecoxib ++++

COX-2, IC50: 18 nM

98%
Asaraldehyde 98%
Naproxen +

COX-1, IC50: 8.7 μM

+

COX-2, IC50: 5.2 μM

98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

+++

COX-2, IC50: 200 nM

98%
NS-398 ++

COX-2, IC50: 3.8 μM

95%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

+++

COX-2, IC50: 150 nM

98%+
Nimesulide +

COX-2, IC50: 26 μM

98%
Lumiracoxib ++

COX-1, Ki: 3 μM

+++

COX-2, Ki: 60 nM

99%
Rutaecarpine 95%
Celecoxib ++++

COX-2, IC50: 40 nM

98%
Carprofen ++++

canine COX2, IC50: 30 nM

98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

++

COX-2 (human), IC50: 3.50 μM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Sulindac sulfone/舒林酸砜 生物活性

描述 Sulindac sulfone is a metabolite of sulindac, a non-steroidal anti-inflammatory drug (NSAID), without anti-inflammatory ability. VDAC1 and VDAC2 (voltage-dependent anion channel) are direct targets of sulindac sulfone which suppresses the mTORC1 pathway and induces G1 arrest[1]. At 100 microMol of sulindac sulfone, a decrease in beta-catenin concentration of 5% was observed; increasing concentrations of sulindac sulfone resulted in >70% reduction in secreted beta-catenin. Sulindac sulfone reduced levels of secreted beta-catenin in the HNSCC (head and neck squamous cell carcinoma) cell line UM-SCC 11A after 48 hours of incubation[2]. Sulindac sulfone inhibited COX-2 (cyclooxygenase) protein expression, which resulted in a decrease in prostaglandin synthase E2 production[3]. Sulindac (20 mg/kg/day), sulindac sulfone (40 mg/kg/day), or vehicle was administered orally to male Sprague-Dawley rats for a 4-wk period beginning 20 wk after tumor induction. Sulindac and sulindac sulfone treatment significantly reduced the number and volume of colorectal tumors compared with control rats[4].

Sulindac sulfone/舒林酸砜 参考文献

[1]Aono Y, Horinaka M, Iizumi Y, Watanabe M, Taniguchi T, Yasuda S, Sakai T. Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1203-1210

[2]Sauter A, Soulsby H, Hormann K, Naim R. Sulindac sulfone induces a decrease of beta-catenin in HNSCC. Anticancer Res. 2010 Feb;30(2):339-43

[3]Taylor MT, Lawson KR, Ignatenko NA, Marek SE, Stringer DE, Skovan BA, Gerner EW. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Res. 2000 Dec 1;60(23):6607-10

[4]de Jong TA, Skinner SA, Malcontenti-Wilson C, Vogiagis D, Bailey M, van Driel IR, O'Brien PE. Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation. Am J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G266-72

Sulindac sulfone/舒林酸砜 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.43mL

2.69mL

1.34mL

26.85mL

5.37mL

2.69mL

Sulindac sulfone/舒林酸砜 技术信息

CAS号59973-80-7
分子式C20H17FO4S
分子量 372.41
SMILES Code CC1=C(C2=C(/C1=C\C3=CC=C(S(C)(=O)=O)C=C3)C=CC(F)=C2)CC(O)=O
MDL No. MFCD00871143
别名
运输蓝冰
InChI Key MVGSNCBCUWPVDA-MFOYZWKCSA-N
Pubchem ID 5472495
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, room temperature

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