Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究
/
动物造模剂
DNA损伤
/
糖尿病模型
DNA烷基化剂/交联剂
/ Streptozotocin/链脲菌素

Streptozotocin/链脲菌素 {[allProObj[0].p_purity_real_show]}

货号：A667625 同义名： 链脲佐菌素 / NSC-85998; SZN

Streptozocin is a potent DNA alkylator with antitumor effects, also used to induce diabete model.

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Streptozotocin/链脲菌素 化学结构 CAS号：18883-66-4
Streptozotocin/链脲菌素 化学结构
CAS号：18883-66-4
Streptozotocin/链脲菌素 3D分子结构
CAS号：18883-66-4
Streptozotocin/链脲菌素 化学结构 CAS号：18883-66-4
Streptozotocin/链脲菌素 3D分子结构 CAS号：18883-66-4
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Streptozotocin/链脲菌素 纯度/质量文件 产品仅供科研

货号：A667625 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

更多 >

Streptozotocin/链脲菌素 生物活性

描述 The alkylation of DNA by carcinogens such as the alkyl nitrosoureas is a critical event in the induction of tumors by these compounds. Streptozotocin, an antibiotic widely used for induction of diabetes in experimental animals and for the treatment of pancreatic neoplasms, was shown to be a potent methylating agent reacting with DNA in vitro to form methylated purines. Rats received streptozotocin (21 mg/kg; 2 mCi/kg) by i.v. injection for 2 hours before death. The liver was alkylated to the greatest extent followed by the kidney. In both of these organs, the degree of methylation was significantly greater than that observed with N-methyl-N-nitrosourea. While methylation of brain DNA by streptozotocin was very low, suggesting that the compound does not penetrate well into the nervous system[3]. Male C57BL/6 mice were under inhalation anesthesia injected via the penile vein with streptozocin (180 mg/kg). Treated mice showed elevated blood glucose levels 48 h after drug injection and reduced body weight significantly compared with control group. Streptozocin also significantly attenuated the numbers of splenocytes and white blood cells (WBC) at 96 h post injection[4].

Streptozotocin/链脲菌素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01362530 Chemotherapy Induced Nausea an... 展开 >>d Vomiting 收起 << Phase 3 Completed - -
NCT01362530 - Completed - -
NCT00003543 Colorectal Cancer Phase 1 Completed - United States, New York ... 展开 >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 收起 <<

Streptozotocin/链脲菌素 参考文献

[1]Diab RA, Fares M, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8.

[2]Bennett RA, Pegg AE. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90.

[3]Bennett RA, Pegg AE. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90. PMID: 6454479.

[4]Diab RA, Fares M, Abedi-Valugerdi M, Kumagai-Braesch M, Holgersson J, Hassan M. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8. doi: 10.1016/j.imlet.2014.12.006. Epub 2015 Jan 5. PMID: 25573197.

Streptozotocin/链脲菌素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.77mL

0.75mL

0.38mL

18.85mL

3.77mL

1.89mL

37.70mL

7.54mL

3.77mL

Streptozotocin/链脲菌素 技术信息

CAS号18883-66-4
分子式C8H15N3O7
分子量 265.22
SMILES Code O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](NC(N(C)N=O)=O)[C@H]1O
MDL No. MFCD00006607
别名 链脲佐菌素 ;NSC-85998; SZN; SZC; NRRL 2697; AI3-50821; NCI-C03167; NSC 37917; Estreptozocin; STZ; U 9889
运输蓝冰
InChI Key ZSJLQEPLLKMAKR-GKHCUFPYSA-N
Pubchem ID 29327
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, store in freezer, under -20°C

Tags: Streptozotocin | Streptozocin;NSC-85998;streptozotocin. SZN;SZC;NRRL 2697;AI3-50821;NCI-C03167;NSC 37917;Estreptozocin;STZ;U 9889 | 链脲佐菌素 | Diabete Model | DNA Alkylator/Crosslinker | AmBeed-信号通路专用抑制剂 | Streptozotocin/链脲菌素 纯度/质量文件 | Streptozotocin/链脲菌素 生物活性 | Streptozotocin/链脲菌素 临床数据 | Streptozotocin/链脲菌素 参考文献 | Streptozotocin/链脲菌素 实验方案 | Streptozotocin/链脲菌素 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z