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抑制剂/激动剂
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NF-κB 糖类
/ Stevioside/甜菊糖

Stevioside/甜菊糖 {[allProObj[0].p_purity_real_show]}

货号：A105391 同义名： 甜菊苷

Stevioside, a natural product isolated and purified from the leaves of Stevia rebaudiana, is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. Stevioside also exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax. Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IκBα/NF-κB signalling pathway.

Stevioside/甜菊糖 化学结构 CAS号：57817-89-7
Stevioside/甜菊糖 化学结构
CAS号：57817-89-7
Stevioside/甜菊糖 3D分子结构
CAS号：57817-89-7
Stevioside/甜菊糖 化学结构 CAS号：57817-89-7
Stevioside/甜菊糖 3D分子结构 CAS号：57817-89-7
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Stevioside/甜菊糖 纯度/质量文件 产品仅供科研

货号：A105391 标准纯度： {[allProObj[0].p_purity_real_show]}
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产品名称 NF-κB ↓ 其他靶点 纯度
PDTC ammonium ✔ 98%
QNZ ++++

NF-κB, IC50: 11 nM

 		99%+
Sodium 4-Aminosalicylate Dihydrate ✔ 98%
Sodium Salicylate ✔ 95%
Parthenolide ✔ p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

 		98%
Phenethyl caffeate ✔ 98%
Andrographolide ✔ 98+%
Curcumin ✔ HDAC,Nrf2 98%
SC75741 +++

NF-κB, EC50: 200 nM

 		99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Stevioside/甜菊糖 生物活性

描述 Stevioside is obtained from leaves of Stevia rebaudiana. Stevioside is an important source of biochemically active substances with proven anti-diabetic effect. Stevioside solution prevented significant increase in glycaemia in oral glucose tolerance test (9.22 ± 1.13 to 9.85 ± 1.32 mmol/l, P < 0.05), and not in adrenaline test[3]. Stevioside inhibited the mRNA and protein expression of TNF-α, IL-6 and IL-1β dose-dependently in S.aureus-stimulated MMECs. Stevioside suppressed the S.aureus-induced expression of TLR2 and proteins of the NF-κB and MAPK pathways as well as apoptosis[4].

Stevioside/甜菊糖 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02880124 Carbohydrate Ingestion ... 展开 >> Fuel Selection Athletic Performance 收起 << Not Applicable Recruiting December 2017 Canada, Quebec ... 展开 >> Centre d'éducation physique et sportive de l'Université de Montréal (CEPSUM) Recruiting Montréal, Quebec, Canada, H3C 3J7 Contact: Mélanie F Paradis, M.Sc.    514-571-4122    melanie.paradis@umontreal.ca    Contact: Lorianne Lavoie, B.Sc.    514-466-3393    lorianne.lavoie@umontreal.ca    Principal Investigator: Jonathan Tremblay, Ph.D. 收起 <<
NCT02634164 Hyperglycemia Not Applicable Completed - -
NCT03115385 Obesity, Abdominal ... 展开 >> Adiposity 收起 << Not Applicable Terminated(Funds ended.) - United States, California ... 展开 >> University of Southern California Los Angeles, California, United States, 90033 收起 <<

Stevioside/甜菊糖 参考文献

[1]Wang T, Song X, et al. Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells. Int Immunopharmacol. 2014 Sep;22(1):192-9.

[2]Boonkaewwan C, Burodom A. Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells. J Sci Food Agric. 2013 Dec;93(15):3820-5.

[3]Ilić V, Vukmirović S, Stilinović N, Čapo I, Arsenović M, Milijašević B. Insight into anti-diabetic effect of low dose of stevioside. Biomed Pharmacother. 2017 Jun;90:216-221. doi: 10.1016/j.biopha.2017.03.045. Epub 2017 Mar 28. PMID: 28363166.

[4]Wang T, Song X, Zhang Z, Guo M, Jiang H, Wang W, Cao Y, Zhu L, Zhang N. Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells. Int Immunopharmacol. 2014 Sep;22(1):192-9. doi: 10.1016/j.intimp.2014.06.015. Epub 2014 Jun 27. PMID: 24975657.

Stevioside/甜菊糖 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.24mL

0.25mL

0.12mL

6.21mL

1.24mL

0.62mL

12.42mL

2.48mL

1.24mL

Stevioside/甜菊糖 技术信息

CAS号57817-89-7
分子式C38H60O18
分子量 804.87
SMILES Code O=C([C@@]1(C)[C@@]2([H])CC[C@@](CC([C@]3(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)CC6)=C)(C3)[C@]6([H])[C@]2(C)CCC1)O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7
MDL No. MFCD00079561
别名 甜菊苷
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Stevioside | 甜菊苷 | Sugar | Natural sweetener | NF-κB | AmBeed-信号通路专用抑制剂 | Stevioside/甜菊糖 纯度/质量文件 | Stevioside/甜菊糖 亚型比较 | Stevioside/甜菊糖 生物活性 | Stevioside/甜菊糖 临床数据 | Stevioside/甜菊糖 参考文献 | Stevioside/甜菊糖 实验方案 | Stevioside/甜菊糖 技术信息

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