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Stattic {[allProObj[0].p_purity_real_show]}

货号：A109795 同义名： STAT3 Inhibitor V

Stattic, a nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

Stattic 化学结构
CAS号：19983-44-9

Stattic 3D分子结构
CAS号：19983-44-9

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Stattic 纯度/质量文件产品仅供科研

货号：A109795 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: 更多 >

STAT 亚型比较

产品名称	STAT1 ↓ ↑	STAT3 ↓ ↑	STAT5 ↓ ↑	纯度
Nifuroxazide	✔			98%
Fludarabine	✔			98%
Artesunate		✔		98%
BP-1-102		+++ STAT3, Kd: 504 nM		99%+
Niclosamide		++ STAT3, IC50: 0.7 μM		98%
Napabucasin		✔		98%
Cryptotanshinone		++ STAT3, IC50: 4.6 μM		98%
Stattic		+ STAT3, IC50: 5.1 μM		98%
NSC 74859		+ STAT3, IC50: 86 μM		99%+
Ochromycinone		✔		98%
HO-3867		✔		97%
C188-9		++++ STAT3, Kd: 4.7 nM		99%+
HJC0152		✔		99%
SH5-07		✔		97%
SH-4-54		++++ STAT3, Kd: 300 nM	+++ STAT5, Kd: 464 nM	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Stattic 生物活性

靶点	STAT3 STAT3, IC50:5.1 μM STAT3 STAT3, IC50:5.1 μM STAT3 STAT3, IC50:5.1 μM
描述	Stattic acts as a potent inhibitor of STAT3 and impedes STAT3 phosphorylation at Y705 and S727 ^[1]. Stattic hampers the binding of a high-affinity phosphopeptide for the SH2 domain of STAT3 ^[2]. Stattic improves renal function in Alport syndrome (AS) mice ^[3].

Stattic 细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
A431	2 μM	Growth Inhibition Assay	2 h	blocks EGF-reversed decreases in cell viability	25720435
A431	2 μM	Growth Inhibition Assay	2 h	increases in apoptosis induced by shikonin	25720435
C13*	0-10 μM	Apoptosis Assay	24/48 h	induces apoptosis in a dose and time dependent manner	23962558
C13*		Apoptosis Assay	24/48 h	enhances cisplatin-induced apoptosis	23962558

Stattic 动物研究

Animal study

Stattic (10 mg/kg, intraperitoneally, three times per week for 10 weeks) improves renal function in Alport syndrome (AS) mice ^[3].

Stattic 参考文献

[1]Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12.

[2]John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13(11):1123-4.

[3]Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33(2):214-223.

Stattic 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.74mL

0.95mL

0.47mL

23.68mL

4.74mL

2.37mL

47.35mL

9.47mL

4.74mL

Stattic 技术信息

CAS号	19983-44-9
分子式	C₈H₅NO₄S
分子量	211.19
SMILES Code	O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]
MDL No.	MFCD00173799

别名	STAT3 Inhibitor V
运输	蓝冰
InChI Key	ZRRGOUHITGRLBA-UHFFFAOYSA-N
Pubchem ID	2779853

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

溶解方案

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

5% DMSO+40% PEG 300+5% Tween 80+50% water 10 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

A431	2 μM	Growth Inhibition Assay	2 h	blocks EGF-reversed decreases in cell viability	25720435
A431	2 μM	Growth Inhibition Assay	2 h	increases in apoptosis induced by shikonin	25720435
C13*	0-10 μM	Apoptosis Assay	24/48 h	induces apoptosis in a dose and time dependent manner	23962558
C13*		Apoptosis Assay	24/48 h	enhances cisplatin-induced apoptosis	23962558
C666-1	0.5-64 μM	Cell Viability Assay	48 h	suppresses cell viability in a dose- and time-dependent manner	23382914
C666-1	1/2 μM	Cell Viability Assay	48 h	sensitize cells to radiotherapy	23382914
Caki-1	10 µM	Growth Inhibition Assay	20 min	enhances sorafenib- and sunitinib-induced growth inhibition	25013907
Cal33		Growth Inhibition Assay		IC50=2.282 ± 0.423 μM, GI50=1.349 ± 0.363 μM	22770899
Cal33	0-30 μM	Function Assay	0-24 h	inhibits STAT3 activation dose and time dependently	22770899
CD4+	10 μm	Apoptosis Assay	24 h	induces apoptosis strongly	24756111
CNE1	20 µM	Function Assay	48 h	blocks the IL-6 increased phosphorylation of Stat3	23382914
CNE1	4 μM	Growth Inhibition Assay		significantly reduces cell viability	23382914
CNE1	0-20 μM	Function Assay	0-4 h	inhibits Stat3 activation in a dose- and time-dependent manner	23382914
CNE1	0.5-64 μM	Cell Viability Assay	48 h	suppresses cell viability in a dose- and time-dependent manner	23382914
CNE1	10 µM	Apoptosis Assay	48 h	induces apoptosis	23382914
CNE2	20 µM	Function Assay	48 h	blocks the IL-6 increased phosphorylation of Stat3	23382914
CNE2	0-20 μM	Function Assay	0-4 h	inhibits Stat3 activation in a dose- and time-dependent manner	23382914
CNE2	0.5-64 μM	Cell Viability Assay	48 h	suppresses cell viability in a dose- and time-dependent manner	23382914
CNE2	10 µM	Apoptosis Assay	48 h	induces apoptosis	23382914
CNE2	1/2 μM	Cell Viability Assay	48 h	sensitize cells to radiotherapy	23382914
CT26	20 mM	Function Assay	1 h	suppresses HGF-induced VEGF expression	23233163
DLD-1	5/10/20 μM	Cell Viability Assay	72 h	inhibits cell viability of the ALDH+/CD133+ cells	21900397
ECA109	0-20 μM	Growth Inhibition Assay	24 h	IC50=5.50 μM	25492480
ECA109	0.5 μM	Clonogenic Survival Assay	24 h	suppresses the clonogenic formation	25492480
ECA109	0.5 μM	Function Assay	24 h	enhances IR-induced generation of DSBs	25492480
ELL-primed hNSCs	0.02-5 μM	Cell Viability Assay	72 h	leads to the loss of cell viability at high concentration	24945434
FHL-primed hNSCs	0.02-5 μM	Cell Viability Assay	72 h	leads to the loss of cell viability at high concentration	24945434
H9c2	10 μM	Function Assay	4 h	reverses the effects of IL-27	26339633
H9c2	2/10 μM	Function Assay	2 h	abrogates the cytoprotective effects of IL-27 against SH	25820907
H9c2	20 µM	Function Assay	30 min	abolishes propofol-induced AKT phosphorylation at both ser473 and thr308	25105067
HaCaT	10 µM	Growth Inhibition Assay	20 min	enhances sorafenib- and sunitinib-induced growth inhibition	25013907
HaCaT	10 µM	Apoptosis Assay	20 min	increases proportions of apoptotic cells due to treatment with sorafenib or sunitinib	25013907
HaCaT	10 µM	Growth Inhibition Assay	20 min	enhances everolimus-induced cell growth inhibition	24423131
HaCaT	10 µM	Apoptosis Assay	20 min	enhances the apoptotic effects of everolimus	24423131
HASMC	1.25-5 μM	Function Assay	20 min	inhibits p-(Y)-STAT-1,3,5 signals	25849622
HCT116	5/10/20 μM	Cell Viability Assay	72 h	inhibits cell viability of the ALDH+/CD133+ cells	21900397
HEC-1A	1 μM	Function Assay	24 h	blocks the MUC20-enhanced invasion triggered by 10% FBS	23262208
HEC-1A	1 μM	Function Assay	24 h	blocks the MUC20-enhanced invasion triggered by EGF	23262208
HepG2	20 μM	Cell Viability Assay	24 h	reduces cell viability	21311975
HMECs	10 μM	Function Assay	2 h	inhibits IFNα mediated phosphorylation of STAT1, STAT2 and STAT3	24211327
HONE1	20 µM	Function Assay	48 h	blocks the IL-6 increased phosphorylation of Stat3	23382914
HONE1	0-20 μM	Function Assay	0-4 h	inhibits Stat3 activation in a dose- and time-dependent manner	23382914
HONE1	0.5-64 μM	Cell Viability Assay	48 h	suppresses cell viability in a dose- and time-dependent manner	23382914
HONE1	10 µM	Apoptosis Assay	48 h	induces apoptosis	23382914
HONE1	1/2 μM	Cell Viability Assay	48 h	sensitize cells to radiotherapy	23382914
HTR8/SVneo	1 μM	Function Assay	1 h	suppressed OSM-induced STAT3 phosphorylation	24060241
HTR8/SVneo	0.5/1 μM	Function Assay	48 h	restores the expression of E-cadherin suppressed by OSM	24060241
HTR8/SVneo	1 μM	Function Assay	48 h	significantly increases migration by OSM	24060241
Huh-7	20 μM	Cell Viability Assay	24 h	reduces cell viability	21311975
HuT-78	1-10 μM	Cell Viability Assay	72 h	causes a dose-dependent inhibition of the viability	24756111
KYSE150	0-20 μM	Growth Inhibition Assay	24 h	IC50=12.64 μM	25492480
KYSE150	0.5 μM	Clonogenic Survival Assay	24 h	suppresses the clonogenic formation	25492480
MCF-7	0.469-3.75 μM	Growth Inhibition Assay	5 d	reduces cell number significantly	24728078
MCF-7/LCC1	0.469-3.75 μM	Growth Inhibition Assay	5 d	reduces cell number significantly	24728078
MCF-7/LCC9	0.469-3.75 μM	Growth Inhibition Assay	5 d	reduces cell number significantly	24728078
MCF7-HER2	0-10 μM	Growth Inhibition Assay	48 h	induces cell death dose dependently	24297508
MCF7-HER2	5 μM	Function Assay	24 h	diminishes Sox-2, Oct-4, and slug expression	24297508
MCF7-HER2	5 μM	Function Assay	24 h	decreases the expression levels of EMT markers, vimentin and slug	24297508
MCF7-HER2	5 μM	Growth Inhibition Assay	24 h	enhances cell growth inhibition combined with Herceptin	24297508
MDA-MB-231	20 μM	Function Assay	2 h	exhibits Snail and E-cadherin expression	25153349
MDA-MB-231	10 µM	Function Assay	24 h	reduces P-STAT3 expression	24376586
MDA-MB-231	10 μM	Apoptosis Assay	24 h	induces apoptosis	17114005
MDA-MB-435S	10 μM	Apoptosis Assay	24 h	induces apoptosis	17114005
Neuro-2a	0-10 μM	Cell Viability Assay	72 h	inhibits cell viability dose dependently	25436682
NPC	0-7.5 µM	Function Assay		abolishes EMT-like molecular alterations, and cell migration and invasion induced by RKIP knockdown	25915430
OSC-19		Growth Inhibition Assay		IC50=3.481 ± 0.953 μM, GI50=1.366 ± 0.770 μM	22770899
OSC-19	0-30 μM	Function Assay	0-24 h	inhibits STAT3 activation dose and time dependently	22770899
OV2008	0-10 μM	Apoptosis Assay	24/48 h	induces apoptosis in a dose and time dependent manner	23962558
OV2008		Apoptosis Assay	24/48 h	enhances cisplatin-induced apoptosis	23962558
PC3M-1E8	2.5/5/10 μM	Function Assay	0-4 h	inhibits the STAT3 activation in a dose- and time-dependent manner	25261365
PC3M-1E8	10 μM	Function Assay	24 h	downregulates Bcl-xL, survivin and c-Myc	25261365
PC3M-1E8	10 μM	Function Assay	24 h	inhibits IL-6 induced STAT3 activation and the IL-6-induced STAT3 activation	25261365
PC3M-1E8	2.5/5/10 μM	Clonogenic Survival Assay		inhibits the colony formation significantly	25261365
PCNs	0-10 μM	Cell Viability Assay	72 h	inhibits cell viability dose dependently	25436682
PGCs	0-10 μM	Cell Viability Assay	72 h	inhibits cell viability dose dependently	25436682
RAW264.7	10 μM	Function Assay	12 h	abrogates the mRNA expressions of JAK2, STAT1, STAT2, and STAT3 induced by DON and T-2 toxin	22454431
RAW264.7	5/10 μM	Apoptosis Assay	45 min	enhances toxins induced apoptosis and MMP loss	22454431
RL95-2	1 μM	Function Assay	24 h	blocks the MUC20-enhanced invasion triggered by 10% FBS	23262208
RL95-2	1 μM	Function Assay	24 h	blocks the MUC20-enhanced invasion triggered by EGF	23262208
SeAx	1-10 μM	Cell Viability Assay	72 h	causes a dose-dependent inhibition of the viability	24756111
SH-SY5Y	0-10 μM	Cell Viability Assay	72 h	inhibits cell viability dose dependently	25436682
SiHa	5-75 nM	Cell Viability Assay	24 h	shows morphology of a typical apoptotic cell and dose-dependent loss of cell viability	25539644
SiHa	5-75 nM	Function Assay	24 h	reduces the phosphorylation at the tyrosine residue 705	25539644
SK-BR-3	10 µM	Function Assay	24 h	reduces P-STAT3 expression	24376586
SNU387	20 μM	Cell Viability Assay	24 h	reduces cell viability	21311975
SNU398	20 μM	Cell Viability Assay	24 h	reduces cell viability	21311975
SS	1-10 μM	Cell Viability Assay	72 h	causes a dose-dependent inhibition of the viability	24756111
SUM-159	10 µM	Function Assay	24 h	reduces P-STAT3 expression	24376586
SW480	5/10/20 μM	Cell Viability Assay	72 h	inhibits cell viability of the ALDH+/CD133+ cells	21900397
SW837	2.5/10 μM	Function Assay	30 min	sensitizes cells to chemoradiotherapy in a dose-dependent manner	23934972
T24	2/10/20 μM	Function Assay	24 h	causes dose-dependent inhibition of the CXCL12-induced increase of invading cells	23526079
TE13	0-20 μM	Growth Inhibition Assay	24 h	IC50=6.15 μM	25492480
TE13	0.5 μM	Clonogenic Survival Assay	24 h	suppresses the clonogenic formation	25492480
Tu-9648	0-10 μM	Cell Viability Assay	72 h	inhibits cell viability dose dependently	25436682
U-373MG	0-10 μM	Cell Viability Assay	72 h	inhibits cell viability dose dependently	25436682
U-87MG	0-10 μM	Cell Viability Assay	72 h	inhibits cell viability dose dependently	25436682
UM-SCC-17B		Growth Inhibition Assay		IC50=2.562 ± 0.409 μM, GI50=1.279 ± 0.194 μM	22770899
UM-SCC-17B	0-30 μM	Function Assay	0-24 h	inhibits STAT3 activation dose and time dependently	22770899
UM-SCC-22B		Growth Inhibition Assay		IC50=2.648 ± 0.542 μM, GI50=1.320 ± 0.204 μM	22770899
UM-SCC-22B	0-30 μM	Function Assay	0-24 h	inhibits STAT3 activation dose and time dependently	22770899
VSMC	3/5/10 μM	Growth Inhibition Assay	30 min	prevents PDGF- and thrombin-mediated VSMC proliferation in a dose-dependent manner	20847306
W480	2.5/10 μM	Function Assay	30 min	sensitizes cells to chemoradiotherapy in a dose-dependent manner	23934972

Stattic {[allProObj[0].p_purity_real_show]}

Stattic 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Stattic 质控信息

Stattic 生物活性

Stattic 细胞研究

Stattic 动物研究

Stattic 参考文献

Stattic 实验方案

Stattic 技术信息

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STAT3	STAT3, IC50:5.1 μM
STAT3	STAT3, IC50:5.1 μM
STAT3	STAT3, IC50:5.1 μM

Stattic {[allProObj[0].p_purity_real_show]}

Stattic 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Stattic 质控信息

Stattic 生物活性

Stattic 细胞研究

Stattic 动物研究

Stattic 参考文献

Stattic 实验方案

Stattic 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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