Stachydrine HCl/盐酸水苏碱
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货号：A556286
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Stachydrine hydrochloride
Stachydrine HCl is a naturally occuring anti-metastatic agent in vitro which is isolated from seed husk and the pulp of the fruit of C. Leonurus.
Stachydrine HCl/盐酸水苏碱 化学结构
Stachydrine HCl/盐酸水苏碱 3D分子结构
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Stachydrine HCl/盐酸水苏碱 纯度/质量文件 产品仅供科研
货号：A556286
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Stachydrine HCl/盐酸水苏碱 质控信息
Stachydrine HCl/盐酸水苏碱 生物活性
描述
Stachydrine hydrochloride, a well-known bioactive ingredients extracted from Herba Leonuri. Stachydrine can inhibit the NF-κB signal pathway with anti-hypertrophic activities. In vitro , IC50 of Stachydrine hydrochloride for MCF-7 and T47D is about 500 µM. High concentrations (500 µM and 1000 µM) of Stachydrine significantly increased the frequency of both studied cell lines at the G1 phase of cell cycle[3] In vivo , Stachydrine hydrochloride can significantly reduce the death rate of mice, improve the pathological changes in the hippocampus, inhibit inflammatory reactions after ischemia[4]
Stachydrine HCl/盐酸水苏碱 参考文献
[1] Wang M, Shu ZJ, et al. Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways. Am J Transl Res. 2017 Apr 15;9(4):1834-1844.
[2] Li X, Wang B, et al. The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice. J Ethnopharmacol. 2013 Jan 9;145(1):241-53.
[3] Wang M, Shu ZJ, Wang Y, Peng W. Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways. Am J Transl Res. 2017 Apr 15;9(4):1834-1844. PMID: 28469788; PMCID: PMC5411931.
[4] Miao M, Wang T, Lou X, MingBai, Xi P, Liu B, Chang B. The influence of stachydrine hydrochloride on the reperfusion model of mice with repetitive cerebral ischemia. Saudi J Biol Sci. 2017 Mar;24(3):658-663. doi: 10.1016/j.sjbs.2017.01.039. Epub 2017 Jan 23. PMID: 28386193; PMCID: PMC5372397.
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Stachydrine HCl/盐酸水苏碱 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
5.57mL
1.11mL
0.56mL
27.83mL
5.57mL
2.78mL
55.67mL
11.13mL
5.57mL
Stachydrine HCl/盐酸水苏碱 技术信息
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