Sirtinol | Sir Two Inhibitor Naphthol | Sirtuin Inhibitor

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Sirtinol/西丁醇 {[allProObj[0].p_purity_real_show]}

货号：A204147 同义名： Sir Two Inhibitor Naphthol

Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.

Sirtinol/西丁醇化学结构
CAS号：410536-97-9

Sirtinol/西丁醇 3D分子结构
CAS号：410536-97-9

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Sirtinol/西丁醇纯度/质量文件产品仅供科研

货号：A204147 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Sirtuin 亚型比较

产品名称	SIRT1 ↓ ↑	SIRT2 ↓ ↑	SIRT3 ↓ ↑	SIRT5 ↓ ↑	SIRT6 ↓ ↑	SIRT7 ↓ ↑	Sirtuin ↓ ↑	其他靶点	纯度
Selisistat	++++ SIRT1, IC50: 38 nM								99%+
Resveratrol	✔								98%
Inauhzin	✔							p53	99%+
Suramin sodium salt	+++ SirT1, IC50: 297 nM			++ SirT5, IC50: 22 μM					99%+
Salermide	✔								99%
Quercetin Dihydrate	✔								95%
Sirtinol	+ SIRT1, IC50: 131 μM	++ SIRT2, IC50: 38 μM							98%+
AGK2		+++ SIRT2, IC50: 3.5 μM							99%+
Tenovin-3		✔						p53	99%+
3-TYP	++++ SIRT1, IC50: 88 nM	++++ SIRT2, IC50: 92 nM	++++ SIRT3, IC50: 16 nM						95%
Tenovin-6	++ SIRT1, IC50: 21 μM	++ SIRT2, IC50: 10 μM	+ SIRT3, IC50: 67 μM					p53	99%+
SirReal2		+++ SIRT2, IC50: 140 nM							99%+
Thiomyristoyl		++++ SIRT2, IC50: 28 nM							99%+
Et-29				✔					98%
OSS_128167	+ SIRT1, IC50: 1578 μM	+ SIRT2, IC50: 751 μM			+ SIRT6, IC50: 89 μM				98%
SIRT7 inhibitor 97491						+++ SIRT7, IC50: 325 nM			97%
Nicotinamide							✔		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Sirtinol/西丁醇生物活性

靶点	SIRT2 SIRT2, IC50:38 μM SIRT2 SIRT2, IC50:38 μM SIRT1 SIRT1, IC50:131 μM SIRT1 SIRT1, IC50:131 μM
描述	Sirtinol is an inhibitor of sirtuin (SIRT), with IC50 values of 48 μM, 57.7 μM, and 131 μM for ySir2, hSIRT2, and hSIRT2, respectively^[1]^[2]^[3]^[4].

Sirtinol/西丁醇细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
human MCF7 cells	30 μM	Proliferation assay	24-72 h	Antiproliferative activity against human MCF7 cells at 30 uM after 24 to 72 hrs	24340169
human MCF7 cells	50 μM	Function assay	24 h	Inhibition of SIRT1 in human MCF7 cells assessed as increase in acetylation of p53 at lys 382 at 50 uM after 24 hrs by Western blot analysis	24340169
human U937 cells	50 μM	Apoptosis assay	45 h	Induction of apoptosis in human U937 cells at 50 uM after 45 hrs by flow cytometry	23189967

Sirtinol/西丁醇动物研究

Animal study

Sirtinol exhibits anti-inflammatory properties by directly inhibiting HNE activity and mitigates HNE-induced and LPS-mediated tissue or organ injury^[3].

Sirtinol/西丁醇参考文献

[1]Wang J, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109.

[2]Fong Y, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051.

[3]Mai A, et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.

[4]Tsai YF, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347.

Sirtinol/西丁醇实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.68mL

2.54mL

1.27mL

25.35mL

5.07mL

2.54mL

Sirtinol/西丁醇技术信息

CAS号	410536-97-9
分子式	C₂₆H₂₂N₂O₂
分子量	394.47
SMILES Code	O=C(NC(C1=CC=CC=C1)C)C2=CC=CC=C2/N=C/C3=C4C=CC=CC4=CC=C3O
MDL No.	MFCD00810186

别名	Sir Two Inhibitor Naphthol
运输	蓝冰
InChI Key	UXJFDYIHRJGPFS-UHFFFAOYSA-N
Pubchem ID	2827646

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, store in freezer, under -20°C

动物实验配方

2% DMSO+30% PEG 300+5% Tween 80+water 0.4 mg/mL

靶点

靶点	数值

SIRT2	SIRT2, IC50:38 μM
SIRT2	SIRT2, IC50:38 μM
SIRT1	SIRT1, IC50:131 μM
SIRT1	SIRT1, IC50:131 μM

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

human MCF7 cells	30 μM	Proliferation assay	24-72 h	Antiproliferative activity against human MCF7 cells at 30 uM after 24 to 72 hrs	24340169
human MCF7 cells	50 μM	Function assay	24 h	Inhibition of SIRT1 in human MCF7 cells assessed as increase in acetylation of p53 at lys 382 at 50 uM after 24 hrs by Western blot analysis	24340169
human U937 cells	50 μM	Apoptosis assay	45 h	Induction of apoptosis in human U937 cells at 50 uM after 45 hrs by flow cytometry	23189967

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Sirtinol/西丁醇 {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

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最近浏览的产品

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Sirtinol/西丁醇纯度/质量文件产品仅供科研

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Sirtinol/西丁醇细胞研究

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