SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Sirtuins are protein deacylases that regulate metabolism and stress responses and are implicated in aging-related diseases[1]. SIRT5 has drawn extensive attention due to its specific catalytic activity for low deacetylation activity but significant desuccinylation, demalonylation and deglutarylation activities[2]. SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM, >100-fold from compound 1[3]. In vivo rat model of ischemia/reperfusion injury, SIRT5 inhibitor 1 (compound 49) reduced the ischemic area, showing a cardioprotective effect against myocardial injury that was higher than that exerted by diazoxide, used as reference cardioprotective drug, and maximum with compound 49[4].
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