Ambeed.cn

首页 / 抑制剂/激动剂 / / JAK / Ruxolitinib phosphate/鲁索利替尼磷酸盐

Ruxolitinib phosphate/鲁索利替尼磷酸盐 {[allProObj[0].p_purity_real_show]}

货号:A157761 同义名: 磷酸鲁索利替尼 / INCB018424 phosphate; Ruxolitinib (phosphate)

Ruxolitinib phosphate is a potent and selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, > 130-fold selectivity for JAK1/2 versus JAK3.

Ruxolitinib phosphate/鲁索利替尼磷酸盐 化学结构 CAS号:1092939-17-7
Ruxolitinib phosphate/鲁索利替尼磷酸盐 化学结构
CAS号:1092939-17-7
Ruxolitinib phosphate/鲁索利替尼磷酸盐 3D分子结构
CAS号:1092939-17-7
Ruxolitinib phosphate/鲁索利替尼磷酸盐 化学结构 CAS号:1092939-17-7
Ruxolitinib phosphate/鲁索利替尼磷酸盐 3D分子结构 CAS号:1092939-17-7
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Ruxolitinib phosphate/鲁索利替尼磷酸盐 纯度/质量文件 产品仅供科研

货号:A157761 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

更多 >
产品名称 JAK1 JAK2 JAK3 Tyk2 其他靶点 纯度
Decernotinib +++

JAK1, IC50: 11 nM

JAK1, Ki: 11 nM

+++

JAK2, Ki: 13 nM

++++

JAK3, Ki: 2.5 nM

+++

TYK2, Ki: 13 nM

99%+
ZM39923 HCl +

JAK1, pIC50: 4.4

+

JAK3, pIC50: 7.1

EGFR 97%
Cerdulatinib +++

JAK1, IC50: 12 nM

+++

JAK2, IC50: 6 nM

+++

JAK3, IC50: 8 nM

++++

TYK2, IC50: 0.5 nM

99%+
Momelotinib +++

JAK1, IC50: 11 nM

++

JAK2, IC50: 18 nM

+

JAK3, IC50: 155 nM

99%+
XL019 +

JAK1, IC50: 134.3 nM

++++

JAK2, IC50: 2.2 nM

+

JAK3, IC50: 214.2 nM

FLT3 99%+
Ruxolitinib +++

JAK1, IC50: 3.3 nM

++++

JAK2, IC50: 2.8 nM

98%
Tofacitinib +

JAK1, IC50: 112 nM

++

JAK2, IC50: 20 nM

++++

JAK3, IC50: 1 nM

98%
Ruxolitinib (S enantiomer) +++

JAK1, IC50: 3.3 nM

++++

JAK2, IC50: 2.8 nM

++

TYK2, IC50: 19 nM

98%
Filgotinib +++

JAK1, IC50: 10 nM

++

JAK2, IC50: 28 nM

+

JAK3, IC50: 810 nM

+

TYK2, IC50: 116 nM

99%
Baricitinib +++

JAK1, IC50: 5.9 nM

+++

JAK2, IC50: 5.7 nM

++

TYK2, IC50: 53 nM

99%
Gandotinib ++

JAK1, IC50: 19.8 nM

++++

JAK2, IC50: 0.288 nM

JAK2 (V617F), Ki: 0.245 nM

++

JAK3, IC50: 48.0 nM

++

TYK2, IC50: 44 nM

FLT3 99%+
Oclacitinib maleate +++

JAK1, IC50: 10nM

++

JAK2, IC50: 18nM

+

JAK3, IC50: 99nM

+

TYK2, IC50: 84nM

98+%
NVP-BSK805 2HCl ++

JAK1, IC50: 31.63 nM

++++

JAK2, IC50: ~0.5 nM

++

JAK3, IC50: 18.68 nM

+++

TYK2, IC50: 10.76 nM

95%
Peficitinib 98%
Go6976 FLT3 99%+
AZD-1480 ++++

JAK2, IC50: 0.26 nM

99%+
Fedratinib +++

JAK2, IC50: 3 nM

JAK2 (V617F), IC50: 3 nM

FLT3,RET 99%+
WP1066 +

JAK2, IC50: 2.3 μM

98%
Curcumol 98%
AZ960 ++++

JAK2, IC50: <3 nM

JAK2, Ki: 0.45 nM

97%
GLPG0634 analog 99%+
CEP-33779 ++++

JAK2, IC50: 1.8 nM

99%+
FLLL32 +

JAK2, IC50: <5 μM

99%+
WHI-P154 +

JAK3, IC50: 1.8 μM

EGFR,VEGFR,Src 98%
BMS-911543 ++++

JAK2, IC50: 1.1 nM

+

JAK3, IC50: 75 nM

++

TYK2, IC50: 66 nM

95%
TG101209 +++

JAK2, IC50: 6 nM

+

JAK3, IC50: 169 nM

FLT3,RET 99%+
AT9283 ++++

JAK2, IC50: 1.2 nM

++++

JAK3, IC50: 1.1 nM

99%+
Pacritinib ++

JAK2, IC50: 23 nM

JAK2 (V617F), IC50: 19 nM

+

JAK3, IC50: 520 nM

++

TYK2, IC50: 50 nM

FLT3 97%
Tofacitinib citrate ++

JAK2, IC50: 20 nM

++++

JAK3, IC50: 1 nM

99%
FM-381 ++++

JAK3, IC50: 127 pM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Ruxolitinib phosphate/鲁索利替尼磷酸盐 生物活性

描述 Ruxolitinib (INCB018424) specifically and potently inhibits signaling and proliferation mediated by JAK2V617F. It inhibits the growth of HEL cells with an EC50 of 186 nM, significantly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell systems, and inhibits proliferation of hematopoietic progenitor cells from primary MPN patient samples[1].

Ruxolitinib phosphate/鲁索利替尼磷酸盐 动物研究

Animal study At a dose of 180 mg/kg administered orally, Ruxolitinib reduces tumor burden in mice injected with JAK2V617F-expressing cells without inducing anemia or lymphopenia[1].

Ruxolitinib phosphate/鲁索利替尼磷酸盐 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03616184 Graft-versus-host-disease (GVH... 展开 >>D) 收起 << Phase 2 Recruiting April 2024 United States, Nebraska ... 展开 >> University of Nebraska Medical Center Recruiting Omaha, Nebraska, United States, 68198 Contact: Penny Nurse Coordinator, RN    402-559-4596 收起 <<
NCT03386214 Myelofibroses Phase 1 Recruiting March 31, 2021 United States, Missouri ... 展开 >> Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Stephen Oh, M.D., Ph.D.    314-747-7960    stoh@wustl.edu    Principal Investigator: Stephen Oh, M.D., Ph.D.          Sub-Investigator: Amy Zhou, M.D. 收起 <<
NCT00674479 Acute Myeloid Leukemia ... 展开 >> Acute Lymphocytic Leukemia Myelodysplastic Syndrome Chronic Myelogenous Leukemia 收起 << Phase 2 Completed - United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<

Ruxolitinib phosphate/鲁索利替尼磷酸盐 参考文献

[1]Quintas-Cardama A, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115(15), 3109-3117.

Ruxolitinib phosphate/鲁索利替尼磷酸盐 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.37mL

2.47mL

1.24mL

24.73mL

4.95mL

2.47mL

Ruxolitinib phosphate/鲁索利替尼磷酸盐 技术信息

CAS号1092939-17-7
分子式C17H21N6O4P
分子量 404.36
SMILES Code N#CC[C@@H](N1N=CC(C2=C3C(NC=C3)=NC=N2)=C1)C4CCCC4.O=P(O)(O)O
MDL No. MFCD18452860
别名 磷酸鲁索利替尼 ;INCB018424 phosphate; Ruxolitinib (phosphate); INCB 018424 (phosphate); INC 424 (phosphate); INC424; INCB018424
运输蓝冰
InChI Key JFMWPOCYMYGEDM-XFULWGLBSA-N
Pubchem ID 25127112
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, 2-8°C

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。