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首页 / 生化试剂 / 类固醇 / 胆汁酸 / Risedronate acid/利塞膦酸

Risedronate acid/利塞膦酸 {[allProObj[0].p_purity_real_show]}

货号：A471285 同义名： Risedronic acid; Risedronate

Risedronic acid is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.

Risedronate acid/利塞膦酸 化学结构 CAS号：105462-24-6
Risedronate acid/利塞膦酸 化学结构
CAS号：105462-24-6
Risedronate acid/利塞膦酸 3D分子结构
CAS号：105462-24-6
Risedronate acid/利塞膦酸 化学结构 CAS号：105462-24-6
Risedronate acid/利塞膦酸 3D分子结构 CAS号：105462-24-6
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Risedronate acid/利塞膦酸 纯度/质量文件 产品仅供科研

货号：A471285 标准纯度： {[allProObj[0].p_purity_real_show]}
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Risedronate acid/利塞膦酸 生物活性

描述 Risedronate (Risedronic acid) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption. Risedronate is hence the first line of bisphosphonates for the reduction of vertebral and non-vertebral fracture risks in postmenopausal women with osteoporosis or those with a high risk of osteoporosis[3]. In experimental models of osteoporosis, risedronate inhibited bone loss and improved trabecular architecture[4]. Higher doses of risedronate (15 mg/day) strongly reduces the marker of cartilage degradation (CTX-II), which could contribute to attenuation of radiological progression of OA by preserving the structural integrity of subchondral bone[5]. Risedronate againsts blood stages of Plasmodium falciparum (50% inhibitory concentration [IC50] of 20.3±1.0 μM). Risedronate leads to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment; however, risedronate treatment did not result in a general increase of survival rates[6].

Risedronate acid/利塞膦酸 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01907269 Osteoporosis Not Applicable Completed - United States, Alabama ... 展开 >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35205 United States, California Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 United States, Massachusetts University of Massachusetts at Worcester Worcester, Massachusetts, United States, 01655 United States, New York New York University New York, New York, United States, 10016 United States, Ohio Jewish Hospital of Cincinnati Cincinnati, Ohio, United States, 45236 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Washington Group Health Research Institute Seattle, Washington, United States, 98101 收起 <<
NCT01907269 - Completed - -
NCT02155595 - Active, not recruiting August 2018 United States, Michigan ... 展开 >> Henry Ford Medical Center, New Center One Detroit, Michigan, United States, 48202 收起 <<

Risedronate acid/利塞膦酸 参考文献

[1]Jordão FM, Saito AY, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

[2]Giljević Z, Vlak T. [Treatment of osteoporosis by risedronate-- speed, efficacy and safety] . Reumatizam. 2006;53(2):66-71. Review. Croatian.

[3]Giljević Z, Vlak T. Brzina, ucinkovitost i sigurnost risedronata u lijecenju osteoporoze [Treatment of osteoporosis by risedronate-- speed, efficacy and safety]. Reumatizam. 2006;53(2):66-71. Croatian

[4]Goa KL, Balfour JA. Risedronate. Drugs Aging. 1998 Jul;13(1):83-91; discussion 92

[5]Iwamoto J, Takeda T, Sato Y, Matsumoto H. Effects of risedronate on osteoarthritis of the knee. Yonsei Med J. 2010 Mar;51(2):164-70

[6]Jordão FM, Saito AY, Miguel DC, de Jesus Peres V, Kimura EA, Katzin AM. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31

Risedronate acid/利塞膦酸 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.53mL

0.71mL

0.35mL

17.66mL

3.53mL

1.77mL

35.32mL

7.06mL

3.53mL

Risedronate acid/利塞膦酸 技术信息

CAS号105462-24-6
分子式C7H11NO7P2
分子量 283.11
SMILES Code OC(P(O)(O)=O)(P(O)(O)=O)CC1=CC=CN=C1
MDL No. MFCD00867080
别名 Risedronic acid; Risedronate; NE 58019
运输蓝冰
InChI Key IIDJRNMFWXDHID-UHFFFAOYSA-N
Pubchem ID 5245
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, 2-8°C

Tags: Risedronic acid | 105462-24-6 | Risedronate | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Risedronate acid/利塞膦酸 纯度/质量文件 | Risedronate acid/利塞膦酸 生物活性 | Risedronate acid/利塞膦酸 临床数据 | Risedronate acid/利塞膦酸 参考文献 | Risedronate acid/利塞膦酸 实验方案 | Risedronate acid/利塞膦酸 技术信息

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