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DNA损伤
细胞周期
/ DNA / RK-33

RK-33 {[allProObj[0].p_purity_real_show]}

货号：A179326

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

RK-33 化学结构 CAS号：1070773-09-9
RK-33 化学结构
CAS号：1070773-09-9
RK-33 3D分子结构
CAS号：1070773-09-9
RK-33 化学结构 CAS号：1070773-09-9
RK-33 3D分子结构 CAS号：1070773-09-9
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RK-33 纯度/质量文件 产品仅供科研

货号：A179326 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Oxolinic acid ✔ 98+%
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

BLM636-1298, IC50: 0.97 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 95%
Favipiravir ✔ 99%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 99%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, IC50: 46.11 nM

Leucyl-tRNA synthetase, Kd: 42.1 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

RK-33 生物活性

靶点

  • helicase

  • helicase
描述 RK-33 demonstrates the ability to inhibit a variety of cancer cell types, with IC50 values ranging between 3-6 µM. However, the PC3 cell line exhibits a much lower sensitivity to RK-33, with an IC50 exceeding 12 µM. Treatment with RK-33 leads to a notable increase in the G1 phase population in DU145 and LNCaP cell lines. In contrast, 22Rv1 cells show only a slight increase in the G1 phase upon RK-33 treatment, along with a significant decrease in the G2 phase population. Additionally, RK-33 induces a moderate elevation in the G1 phase in 22Rv1 cells[1].

RK-33 细胞研究

细胞系 浓度 检测类型 检测时间 活性说明 数据源
A549 cells Cytotoxicity assay 72 h Cytotoxicity against human A549 cells after 72 hrs by WST1 assay, IC50=2.5 μM 21572541
A549 cells Cytotoxicity assay 72 h Cytotoxicity against human A549 cells after 72 hrs by WST1 assay, IC50=2.56 μM 23290252
H460 cells Cytotoxicity assay 72 h Cytotoxicity against human H460 cells after 72 hrs by WST1 assay, IC50=2.8 μM 21572541
MCF7 cells Cytotoxicity assay 72 h Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay, IC50=7.5 μM 21572541

RK-33 参考文献

[1]Xie M, Vesuna F, et al. RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3. Cancer Res. 2016 Nov 1;76(21):6340-6350. Epub 2016 Sep 12.

[2]Bol GM, Vesuna F, et al. Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. EMBO Mol Med. 2015 May;7(5):648-69.

RK-33 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.33mL

0.47mL

0.23mL

11.67mL

2.33mL

1.17mL

23.34mL

4.67mL

2.33mL

RK-33 技术信息

CAS号1070773-09-9
分子式C23H20N6O3
分子量 428.44
SMILES Code O=C1N(CC2=CC=C(OC)C=C2)C3=NC=NC4=C(N=CN4CC5=CC=C(OC)C=C5)C3=N1
MDL No. MFCD30489740
别名
运输蓝冰
InChI Key COUMZXFUZDBRCZ-UHFFFAOYSA-N
Pubchem ID 46184988
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

Tags: RK-33 | 1070773-09-9 | RK33 | RK 33 | DNA/RNA Synthesi Inhibitor | Cell Cycle/DNA Damage | DNA/RNA Synthesis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | RK-33 纯度/质量文件 | RK-33 亚型比较 | RK-33 生物活性 | RK-33 细胞研究 | RK-33 参考文献 | RK-33 实验方案 | RK-33 技术信息

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