Quercetin | Sophoretin;C.I. 75720;Xanthaurine.;Quertine;Quercetol;Quercetine;NSC 9219;NCI-C60106;Meletin;Kvercetin;NSC 9221 | Plant Standard

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Quercetin/槲皮素 {[allProObj[0].p_purity_real_show]}

货号：A292006 同义名： Sophoretin; C.I. 75720

Quercetin is a flavonoid isolated and purified from the flower bud of Sophora flavescens Ait., with anticancer activity. It is also a mitochondrial ATPase and phosphodiesterase inhibitor and Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity.

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Quercetin/槲皮素化学结构
CAS号：117-39-5

Quercetin/槲皮素 3D分子结构
CAS号：117-39-5

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Quercetin/槲皮素纯度/质量文件产品仅供科研

货号：A292006 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Quercetin/槲皮素生物活性

靶点

Src
Src
p110β

PI3Kβ, IC50:5.4 μM
p110δ

PI3Kδ, IC50:3.0 μM

描述

Quercetin, recognized for its presence in various dietary sources as a natural flavonoid, serves dual roles both as a stimulator of recombinant SIRT1 and as an inhibitor of PI3K, exhibiting IC50 values between 2.4 and 5.4 μM across different PI3K isoforms^[1]. Quercetin GMP, which is Quercetin produced under Good Manufacturing Practice (GMP) guidelines, serves as an auxiliary reagent in cell therapy manufacturing, leveraging its status as a flavonoid antioxidant, PI3K inhibitor, and SIRT1 activator^[1].^[2].^[3].^[4].^[5].^[6].

Quercetin/槲皮素细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
HEK293 FS cells		Function assay		Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=0.68 μM	20731357
HT22 cells		Function assay		Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells, EC50=2.98 μM	16392814
HT22 cells		Function assay		Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay, EC50=3.13 μM	24602904
human 2008 cells		Cytotoxicity assay	72 h	Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=21.18 μM	25906385

Quercetin/槲皮素动物研究

Animal study

In vivo, a combination of quercetin (75 mg/kg) with 2-Methoxyestradiol notably suppresses tumor growth in human prostate cancer LNCaP and PC-3 cells xenograft models^[3].

Quercetin/槲皮素参考文献

[1]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80.

[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.

[3]Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277.

[4]Woo JT, et al. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr;27(4):504-9.

[5]Kim YJ, et al. Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochem Pharmacol. 2006 Nov 15;72(10):1268-78.

[6]Pang XG, et al. Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. Biomed Res Int. 2018 Mar 15;2018:4178021.

Quercetin/槲皮素实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL

Quercetin/槲皮素技术信息

CAS号	117-39-5
分子式	C₁₅H₁₀O₇
分子量	302.24
SMILES Code	O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=C1C(O)=CC(O)=C3
MDL No.	MFCD00006828

别名	Sophoretin; C.I. 75720; Xanthaurine.; Quertine; Quercetol; Quercetine; NSC 9219; NCI-C60106; Meletin; Kvercetin; NSC 9221
运输	蓝冰
InChI Key	REFJWTPEDVJJIY-UHFFFAOYSA-N
Pubchem ID	5280343

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

动物实验配方

2% DMSO+30% PEG 300+2% Tween 80+water 6 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

HEK293 FS cells		Function assay		Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=0.68 μM	20731357
HT22 cells		Function assay		Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells, EC50=2.98 μM	16392814
HT22 cells		Function assay		Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay, EC50=3.13 μM	24602904
human 2008 cells		Cytotoxicity assay	72 h	Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=21.18 μM	25906385
human A431 cells		Cytotoxicity assay	72 h	Cytotoxicity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=23.04 μM	25906385
human A549 cells		Function assay		Anticancer activity against human A549 cells by HTS assay, IC50=6.2 μM	25139569
human BV2 cells		Function assay	24 h	Inhibition of LPS-stimulated NO production in human BV2 cells after 24 hrs by Griess assay, IC50=4.3 μM	25127164
human BV2 cells		Function assay		Antiinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production by Griess assay, IC50=10 μM	24707938
human BxPC3 cells		Cytotoxicity assay	72 h	Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=24.12 μM	25906385
human H460 cells		Function assay		Anticancer activity against human H460 cells by HTS assay, IC50=9.62 μM	25139569
human HCT116 cells		Growth inhibition assay	48 h	Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay, IC50=5.7 μM	22212721
human HCT116 cells		Growth inhibition assay	48 h	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay, IC50=6.7 μM	22212721
human HeLa cells		Function assay		Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay, Ki=2.4 μM	19725578
human HepG2 cells		Cytotoxicity assay		Cytotoxicity against human HepG2 cells by MTT assay, IC50=30.9 μM	21726077
human HOP62 cells		Function assay		Anticancer activity against human HOP62 cells by HTS assay, IC50=7.52 μM	25139569
human HTLA cells		Function assay	20 mins	Inhibition of CX3CL1-stimulated CX3CR1 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay, IC50=4.5 μM	23437772
human LOXIMVI cells		Function assay		Anticancer activity against human LOXIMVI cells by HTS assay, IC50=4.65 μM	25139569
human MCF7 cells		Cytotoxicity assay	72 h	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=20.9 μM	25906385
human MDA-MB-231 cells	20 μM	Function assay	12 h	Induction of apoptosis in human MDA-MB-231 cells assessed as cleaved caspase-7 accumulation at 20 uM after 12 hrs by Western blot analysis	21652208
human NCI-H157 cells		Function assay		Anticancer activity against human NCI-H157 cells by HTS assay, IC50=6 μM	25139569
human NCI-H522 cells		Function assay		Anticancer activity against human NCI-H522 cells by HTS assay, IC50=5.77 μM	25139569
human U2OS cells		Function assay		Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay, EC50=5.93 μM	24900447
Jurkat T cells		Function assay		Activity against hydrogen peroxide induced DNA damage in Jurkat T cells, IC50=5 μM	16392814
MDCK cells		Function assay		Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining, IC50=6.9 μM	21354800
NCI-H1792 cells		Function assay		Anticancer activity against human NCI-H1792 cells by HTS assay, IC50=3.85 μM	25139569
RAW264.7 cells		Function assay	24 h	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs, IC50=1.3 μM	23540981
RBL-1 cells		Function assay		In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=0.2 μM	8254620
Sf9 cells		Function assay		Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method, Ki=45.3 nM	20146483

Quercetin/槲皮素 {[allProObj[0].p_purity_real_show]}

Quercetin/槲皮素纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Quercetin/槲皮素质控信息

Quercetin/槲皮素生物活性

Quercetin/槲皮素细胞研究

Quercetin/槲皮素动物研究

Quercetin/槲皮素参考文献

Quercetin/槲皮素实验方案

Quercetin/槲皮素技术信息

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Src
Src
p110β	PI3Kβ, IC50:5.4 μM
p110δ	PI3Kδ, IC50:3.0 μM
p110γ	PI3Kγ, IC50:2.4 μM
PKC
PKC
PKC

Quercetin/槲皮素 {[allProObj[0].p_purity_real_show]}

Quercetin/槲皮素 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Quercetin/槲皮素 质控信息

Quercetin/槲皮素 生物活性

Quercetin/槲皮素 细胞研究

Quercetin/槲皮素 动物研究

Quercetin/槲皮素 参考文献

Quercetin/槲皮素 实验方案

Quercetin/槲皮素 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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G

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Quercetin/槲皮素纯度/质量文件产品仅供科研

Quercetin/槲皮素质控信息

Quercetin/槲皮素生物活性

Quercetin/槲皮素细胞研究

Quercetin/槲皮素动物研究

Quercetin/槲皮素参考文献

Quercetin/槲皮素实验方案

Quercetin/槲皮素技术信息