Pipobroman/哌泊溴烷
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货号：A163585
同义名：
PB; Vercyte
Pipobroman is an anti-cancer drug that probably acts as an alkylating agent.
Pipobroman/哌泊溴烷 化学结构
Pipobroman/哌泊溴烷 3D分子结构
规格
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会员价
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Pipobroman/哌泊溴烷 纯度/质量文件 产品仅供科研
货号：A163585
标准纯度：
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Pipobroman/哌泊溴烷 质控信息
Pipobroman/哌泊溴烷 生物活性
描述
Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al[3] [4]
Pipobroman/哌泊溴烷 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT01243944
Polycythemia Vera
Phase 3
Completed
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NCT02038036
Polycythemia Vera
Phase 3
Active, not recruiting
April 8, 2020
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NCT01243944
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Completed
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Pipobroman/哌泊溴烷 参考文献
[1] Kiladjian JJ, Chevret S, et al. Treatment of polycythemia vera with hydroxyurea and pipobroman: final results of a randomized trial initiated in 1980. J Clin Oncol. 2011 Oct 10;29(29):3907-13.
[2] Passamonti F, Lazzarino M. Treatment of polycythemia vera and essential thrombocythemia: the role of pipobroman. Leuk Lymphoma. 2003 Sep;44(9):1483-8.
[3] Cassius C, Pages C, Roux J, Lhote R, Lavocat R, Réa D, Bagot M, Mourah S, Battistella M, Lebbé C, Dumaz N. Association of Vemurafenib and Pipobroman Enhances BRAF-CRAF Dimerization in Squamous Cell Carcinoma. J Invest Dermatol. 2016 Jun;136(6):1302-1305
[4] Passamonti F, Malabarba L, Orlandi E, Pascutto C, Brusamolino E, Astori C, Baratè C, Canevari A, Corso A, Bernasconi P, Cazzola M, Lazzarino M. Pipobroman is safe and effective treatment for patients with essential thrombocythaemia at high risk of thrombosis. Br J Haematol. 2002 Mar;116(4):855-61
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Pipobroman/哌泊溴烷 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.81mL
0.56mL
0.28mL
14.04mL
2.81mL
1.40mL
28.09mL
5.62mL
2.81mL
Pipobroman/哌泊溴烷 技术信息
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