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Pinoresinol Diglucoside/松脂醇二葡萄糖苷 {[allProObj[0].p_purity_real_show]}

货号:A468639 同义名: 松酯醇二葡萄糖苷 / (+)-Pinoresinol di-O-β-D-glucopyranoside

Pinoresinol diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.

Pinoresinol Diglucoside/松脂醇二葡萄糖苷 化学结构 CAS号:63902-38-5
Pinoresinol Diglucoside/松脂醇二葡萄糖苷 化学结构
CAS号:63902-38-5
Pinoresinol Diglucoside/松脂醇二葡萄糖苷 3D分子结构
CAS号:63902-38-5
Pinoresinol Diglucoside/松脂醇二葡萄糖苷 化学结构 CAS号:63902-38-5
Pinoresinol Diglucoside/松脂醇二葡萄糖苷 3D分子结构 CAS号:63902-38-5
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Pinoresinol Diglucoside/松脂醇二葡萄糖苷 纯度/质量文件 产品仅供科研

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Pinoresinol Diglucoside/松脂醇二葡萄糖苷 生物活性

描述 Pinoresinol diglucoside (PDG) is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species. PDG (5 mg/kg and 10 mg/kg) exerts anti-inflammatory and antioxidation effects via regulating the NF-κB pathway and Nrf2/HO-1 pathway, thereby reducing the I/R(ischemia/reperfusion)-induced brain injury of mice[3]. PDG (5 and 10 mg/kg, i.g.) can attenuate neuroinflammation, neuronal apoptosis and oxidative stress through the TLR4/NF-κB and Nrf2/HO-1 pathways, and ameliorate memory dysfunction induced by Aβ1-42 in mice[4]. PDG (2.5 mg/kg, 5 mg/kg, 7.5 mg/kg per day) treatment prevented cardiac histomorphology damages, decreased upregulations of hypertrophic biomarkers, and prevented fibrosis and inflammation after pressure overload resulting from AAC(abdominal aortic constriction)-surgery. Consistently, PDG remarkably inhibited the changes of cardiomyocyte hypertrophic biomarkers and inflammatory responses in cellular models of CM. PDG administration inhibited the activation of AKT/mTOR/NF-kB signaling pathway both in vivo and in vitro[5].

Pinoresinol Diglucoside/松脂醇二葡萄糖苷 参考文献

[1]Zhang Y, Shi J, et al. Production of pinoresinol diglucoside, pinoresinol monoglucoside, and pinoresinol by Phomopsis sp. XP-8 using mung bean and its major components. Appl Microbiol Biotechnol. 2015 Jun;99(11):4629-43.

[2]Song JZ, Cheung LM, et al. Development and validation of an ultra high-performance liquid chromatographic method for the determination of a diastereomeric impurity in (+)-pinoresinol diglucoside chemical reference substance. J Sep Sci. 2010 Jul;33(13):1909-15.

[3]Zhang Y, Lei Y, Yao X, Yi J, Feng G. Pinoresinol diglucoside alleviates ischemia/reperfusion-induced brain injury by modulating neuroinflammation and oxidative stress. Chem Biol Drug Des. 2021 Dec;98(6):986-996

[4]Lei S, Wu S, Wang G, Li B, Liu B, Lei X. Pinoresinol diglucoside attenuates neuroinflammation, apoptosis and oxidative stress in a mice model with Alzheimer's disease. Neuroreport. 2021 Feb 3;32(3):259-267

[5]Chen Y, Pan R, Zhang J, Liang T, Guo J, Sun T, Fu X, Wang L, Zhang L. Pinoresinol diglucoside (PDG) attenuates cardiac hypertrophy via AKT/mTOR/NF-κB signaling in pressure overload-induced rats. J Ethnopharmacol. 2021 May 23;272:113920

Pinoresinol Diglucoside/松脂醇二葡萄糖苷 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.46mL

0.29mL

0.15mL

7.32mL

1.46mL

0.73mL

14.65mL

2.93mL

1.46mL

Pinoresinol Diglucoside/松脂醇二葡萄糖苷 技术信息

CAS号63902-38-5
分子式C32H42O16
分子量 682.67
SMILES Code COC(C=C1[C@@H]2[C@](CO[C@@H]3C4=CC(OC)=C(O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO)C=C4)([H])[C@]3([H])CO2)=C(C=C1)O[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO
MDL No. MFCD06656077
别名 松酯醇二葡萄糖苷 ;(+)-Pinoresinol di-O-β-D-glucopyranoside
运输蓝冰
InChI Key ZJSJQWDXAYNLNS-FUPWJLLWSA-N
Pubchem ID 174003
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, store in freezer, under -20°C

溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
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