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/ Pentamidine isethionate/喷他脒羟乙基磺酸盐

Pentamidine isethionate/喷他脒羟乙基磺酸盐 {[allProObj[0].p_purity_real_show]}

货号：A668797 同义名： 喷他脒羟乙磺酸盐 / MP-601205 isethionate; Pentamidine(isethionate)

Pentamidine Isethionate is a synthetic amidine-derived antiprotozoal and antifungal agent.

Pentamidine isethionate/喷他脒羟乙基磺酸盐 化学结构 CAS号：140-64-7
Pentamidine isethionate/喷他脒羟乙基磺酸盐 化学结构
CAS号：140-64-7
Pentamidine isethionate/喷他脒羟乙基磺酸盐 3D分子结构
CAS号：140-64-7
Pentamidine isethionate/喷他脒羟乙基磺酸盐 化学结构 CAS号：140-64-7
Pentamidine isethionate/喷他脒羟乙基磺酸盐 3D分子结构 CAS号：140-64-7
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Pentamidine isethionate/喷他脒羟乙基磺酸盐 纯度/质量文件 产品仅供科研

货号：A668797 标准纯度： {[allProObj[0].p_purity_real_show]}
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Pentamidine isethionate/喷他脒羟乙基磺酸盐 生物活性

描述 Pentamidine isethionate, an aromatic diamidine, is an antiprotozoal agent proven to decrease mortality from Pneumocystis carinii pneumonia in debilitated infants and immunodeficient adults and children[3]. The use of intramuscular pentamidine isethionate in the treatment of Leishmania guyanensis cutaneous leishmaniasis is associated with more treatment failures than intravenous pentamidine isethionate[4]. PI (Pentamidine Isethionate) is a safe drug and its efficacy varied with the number of doses. The administration of PI in patients with ACL (American Cutaneous Leishmaniasis), predominantly caused by L. guyanensis, was mostly efficient in three or two doses of 7 mg/kg[5].

Pentamidine isethionate/喷他脒羟乙基磺酸盐 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00141037 Kidney Diseases ... 展开 >> Kidney Transplantation Kidney Transplant Renal Transplantation Renal Transplant 收起 << Phase 1 Phase 2 Completed - United States, Alabama ... 展开 >> University of Alabama - Pediatric Nephrology Birmingham, Alabama, United States, 35233 United States, California Maxine Dunitz Children's Health Center Cedars-Sinai Los Angeles, California, United States, 90048 UCLA - Department of Pediatrics, Division of Nephrology Los Angeles, California, United States, 90095-1752 Stanford University Medical Center, Lucile Packard Children's Hospital Palo Alto, California, United States, 94304 UCSF Children's Hospital San Francisco, California, United States, 94143 United States, Florida University of Florida - Pediatric Nephrology Gainesville, Florida, United States, 32610-0296 United States, Louisiana Children's Hospital of New Orleans-Department of Pediatric Nephrology New Orleans, Louisiana, United States, 70118 United States, Massachusetts Children's Hospital Boston - Division of Nephrology Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Medical Center, C.S. Mott Children's Hospital- Division of Nephrology & Transplantation Ann Arbor, Michigan, United States, 48109 United States, Missouri Children's Mercy Hospital - Department of Nephrology Kansas City, Missouri, United States, 64108 United States, Pennsylvania The Children's Hospital of Philadelphia-Department of Nephrology Philadelphia, Pennsylvania, United States, 19104 United States, Washington Children's Hospital & Regional Medical Center - Division of Nephrology Seattle, Washington, United States, 98105 收起 <<
NCT00014911 Diabetes Mellitus, Insulin-Dep... 展开 >>endent 收起 << Phase 2 Completed - United States, Florida ... 展开 >> University of Miami Miami, Florida, United States, 33136 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington University St. Louis, Missouri, United States, 63110 United States, Washington Benaroya Research Institute at Virginia Mason Research Center Seattle, Washington, United States, 98101 Canada, Alberta University of Alberta Edmonton, Alberta, Canada Germany Justus-Leibig University Giessen, Germany, 35385 Italy University of Milan Milan, Italy Switzerland University of Geneva Geneva, Switzerland 收起 <<
NCT00141037 - Completed - -

Pentamidine isethionate/喷他脒羟乙基磺酸盐 参考文献

[1]Nguewa PA, Fuertes MA, et al. Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers. 2005 Oct;2(10):1387-400.

[2]Sands M, Kron MA, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.

[3]Goa KL, Campoli-Richards DM. Pentamidine isethionate. A review of its antiprotozoal activity, pharmacokinetic properties and therapeutic use in Pneumocystis carinii pneumonia. Drugs. 1987;33(3):242–258

[4]Christen JR, Bourreau E, Demar M, et al. Use of the intramuscular route to administer pentamidine isethionate in Leishmania guyanensis cutaneous leishmaniasis increases the risk of treatment failure. Travel Med Infect Dis. 2018;24:31–36

[5]Gadelha EPN, Ramasawmy R, da Costa Oliveira B, et al. An open label randomized clinical trial comparing the safety and effectiveness of one, two or three weekly pentamidine isethionate doses (seven milligrams per kilogram) in the treatment of cutaneous leishmaniasis in the Amazon Region. PLoS Negl Trop Dis. 2018;12(10):e0006850. Published 2018 Oct 31

Pentamidine isethionate/喷他脒羟乙基磺酸盐 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.44mL

1.69mL

0.84mL

16.87mL

3.37mL

1.69mL

Pentamidine isethionate/喷他脒羟乙基磺酸盐 技术信息

CAS号140-64-7
分子式C23H36N4O10S2
分子量 592.68
SMILES Code N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.OCCS(=O)(O)=O.OCCS(=O)(O)=O
MDL No. MFCD00079213
别名 喷他脒羟乙磺酸盐 ;MP-601205 isethionate; Pentamidine(isethionate)
运输蓝冰
InChI Key YBVNFKZSMZGRAD-UHFFFAOYSA-N
Pubchem ID 8813
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Pentamidine isethionate | MP-601205 isethionate | 喷他脒羟乙磺酸盐 | Insect Repellent | Phosphatase | Antibacterial | AmBeed-信号通路专用抑制剂 | Pentamidine isethionate/喷他脒羟乙基磺酸盐 纯度/质量文件 | Pentamidine isethionate/喷他脒羟乙基磺酸盐 生物活性 | Pentamidine isethionate/喷他脒羟乙基磺酸盐 临床数据 | Pentamidine isethionate/喷他脒羟乙基磺酸盐 参考文献 | Pentamidine isethionate/喷他脒羟乙基磺酸盐 实验方案 | Pentamidine isethionate/喷他脒羟乙基磺酸盐 技术信息

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