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首页 / 抑制剂/激动剂 / MAPK/ERK Pathway / p38 MAPK / PD 169316

PD 169316 {[allProObj[0].p_purity_real_show]}

货号：A530681

PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).

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PD 169316 化学结构 CAS号：152121-53-4
PD 169316 化学结构
CAS号：152121-53-4
PD 169316 3D分子结构
CAS号：152121-53-4
PD 169316 化学结构 CAS号：152121-53-4
PD 169316 3D分子结构 CAS号：152121-53-4
规格 价格 会员价 库存 数量
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PD 169316 纯度/质量文件 产品仅供科研

货号：A530681 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 p38 MAPK ↓ p38α ↓ p38β ↓ 其他靶点 纯度
BMS-582949 +++

p38 MAPK, IC50: 13 nM

 		98%
SB 203580 99%+
Pexmetinib ✔ Tie-2 99%+
Skepinone-L ++++

p38α, IC50: 5 nM

 		98%
Doramapimod ++++

p38α, Kd: 0.1 nM

p38α, IC50: 38 nM

 		99%+
VX-702 99%+
Ralimetinib dimesylate ++++

p38α, IC50: 7 nM

 		98%
SB 202190 ++

p38α, IC50: 50 nM

 		++

p38β, IC50: 100 nM

 		99%+
Losmapimod ++++

p38α, pKi: 8.1

 		+++

p38β, pKi: 7.6

 		99%+
Neflamapimod +++

p38α, IC50: 10 nM

 		+

p38β, IC50: 220 nM

 		99%+
PH-797804 ++

p38α, IC50: 26 nM

 		+

p38β, IC50: 102 nM

 		99%
TAK-715 ++++

p38α, IC50: 7.1 nM

 		+

p38β, IC50: 0.20 μM

 		99%+
SB 239063 ++

p38α, IC50: 44 nM

 		++

p38β, IC50: 44 nM

 		99%+
Pamapimod +++

p38α, IC50: 0.014 μM

 		+

p38β, IC50: 0.48 μM

 		98%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

PD 169316 生物活性

描述 PD 169316 is a potent and selective p38 MAP kinase inhibitor. It blocked p38 enzyme activity activated by serum-starvation and apoptosis by approximately 80% in Rat-1 fibroblasts at concentration of 10μM. PD169316 at 5μM or higher abrogated signaling initiated by both TGFβ and Activin A, but not BMP4, in CaOV3 cells. PD169316 at 10μM blocked the apoptotic process induced upon LIF withdrawal, without impairing cell differentiation, in mouse ES cells, with decreased FGF-5 and increased Bcl-2 expression on RNA level observed post 3 days.

PD 169316 动物研究

Dose Mice: 60 mg/kg[4] (p.o.); 1 mg/kg[5] (i.m.)
Administration p.o., i.m.

PD 169316 参考文献

[1]Kummer JL, Rao PK, et al. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 1997 Aug 15;272(33):20490-4.

[2]Fu Y, O'Connor LM, et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7.

[3]Duval D, Malaisé M, et al. A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells. Cell Death Differ. 2004 Mar;11(3):331-41.

PD 169316 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.88mL

2.78mL

1.39mL

27.75mL

5.55mL

2.78mL

PD 169316 技术信息

CAS号152121-53-4
分子式C20H13FN4O2
分子量 360.34
SMILES Code O=[N+](C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)[O-]
MDL No. MFCD12405019
别名
运输蓝冰
InChI Key BGIYKDUASORTBB-UHFFFAOYSA-N
Pubchem ID 4712
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, sealed in dry, 2-8°C

Tags: PD 169316 | 152121-53-4 | PD169316 | PD-169316 | p38 MAP Kinase Inhibitor | MAPK/ERK Pathway | Autophagy | Anti-infection | p38 MAPK | Autophagy | Enterovirus | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | PD 169316 纯度/质量文件 | PD 169316 亚型比较 | PD 169316 生物活性 | PD 169316 动物研究 | PD 169316 参考文献 | PD 169316 实验方案 | PD 169316 技术信息

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