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抑制剂/激动剂
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/ Niclosamide/氯硝柳胺

Niclosamide/氯硝柳胺 {[allProObj[0].p_purity_real_show]}

货号：A108674 同义名： BAY2353; NSC 178296

Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibits the phosphorylation of STAT3 and has no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5). It is also an antiparasitic agent. It induced apoptosis by activating the intrinsic and caspase-independent pathway in human A549 and CL1-5 cells.

Niclosamide/氯硝柳胺 化学结构 CAS号：50-65-7
Niclosamide/氯硝柳胺 化学结构
CAS号：50-65-7
Niclosamide/氯硝柳胺 3D分子结构
CAS号：50-65-7
Niclosamide/氯硝柳胺 化学结构 CAS号：50-65-7
Niclosamide/氯硝柳胺 3D分子结构 CAS号：50-65-7
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Niclosamide/氯硝柳胺 纯度/质量文件 产品仅供科研

货号：A108674 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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ULK1, IC50: 108 nM

ULK2, IC50: 711 nM

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PFK-015 ++

PFKFB3, IC50: 207 nM

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MRT68921 HCl ++++

ULK1, IC50: 2.9 nM

ULK2, IC50: 1.1 nM

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ROC-325 ✔ 99%+
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Autophagy, IC50: 40 nM

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Lys05 ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 STAT1 ↓ STAT3 ↓ STAT5 ↓ 其他靶点 纯度
Nifuroxazide ✔ 98%
Fludarabine ✔ 98%
Artesunate ✔ 98%
BP-1-102 +++

STAT3, Kd: 504 nM

 		99%+
Niclosamide ++

STAT3, IC50: 0.7 μM

 		98%
Napabucasin ✔ 98%
Cryptotanshinone ++

STAT3, IC50: 4.6 μM

 		98%
Stattic +

STAT3, IC50: 5.1 μM

 		98%
NSC 74859 +

STAT3, IC50: 86 μM

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Ochromycinone ✔ 98%
HO-3867 ✔ 97%
C188-9 ++++

STAT3, Kd: 4.7 nM

 		99%+
HJC0152 ✔ 99%
SH5-07 ✔ 97%
SH-4-54 ++++

STAT3, Kd: 300 nM

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STAT5, Kd: 464 nM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Niclosamide/氯硝柳胺 生物活性

靶点

  • STAT3

    STAT3, IC50:0.7 μM

  • STAT3

    STAT3, IC50:0.7 μM

  • STAT3

    STAT3, IC50:0.7 μM
描述 Niclosamide (BAY2353) is an orally active antihelminthic agent primarily employed in research related to parasitic infections[1]. Niclosamide also functions as a potent STAT3 inhibitor, demonstrating an IC50 of 0.25 μM in HeLa cells[4]. Additionally, Niclosamide exhibits anticancer properties and can inhibit DNA replication in Vero E6 cells[2].[3].[5]. Niclosamide, produced under Good Manufacturing Practice (GMP) guidelines as Niclosamide, is used in parasitic infection research and also serves as an auxiliary reagent for cell therapy manufacturing[1]. This formulation maintains its potency as a STAT3 inhibitor with an IC50 of 0.25 µM in HeLa cells[4]. Niclosamide shows anti-cancer activities, including the inhibition of DNA replication in Vero E6 cells[2].[3].[5].

Niclosamide/氯硝柳胺 细胞研究

细胞系 浓度 检测类型 检测时间 活性说明 数据源
CHO cells Function assay Cytoprotective activity against anthrax fusion toxin FP59-induced cell death in CHO cells assessed as cell viability by MTT reduction assay 19540764
HEK293 cells Function assay 8 h Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs, IC50=0.34 μM 26272032
HEK293 cells Function assay 8 h Inhibition of Wnt3A/beta-casein signaling in HEK293 cells after 8 hrs by TOPflash reporter assay, IC50=0.4 μM 23453073
human A431 cells Proliferation assay 72 h Antiproliferative activity against human A431 cells after 72 hrs by MTT assay, IC50=8.8 μM 24900231

Niclosamide/氯硝柳胺 动物研究

Animal study In vivo, Niclosamide administered via oral gavage at doses of 100 mg/kg and 200 mg/kg once a week over eight weeks, significantly reduces tumor growth in models of adrenocortical carcinoma[3].The same dosage and administration schedule for Niclosamide (100 mg/kg, 200 mg/kg; oral gavage; once a week; 8 weeks) is used to inhibit tumor growth in adrenocortical carcinoma in vivo, confirming its therapeutic potential across different formulations and applications[3].

Niclosamide/氯硝柳胺 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01296958 Taenia Solium Taeniasis Not Applicable Completed - Peru ... 展开 >> San Marcos University Lima, Peru 收起 <<
NCT01189903 Asian Colorectal Cancer Patien... 展开 >>ts 收起 << Phase 2 Phase 3 Unknown - Singapore ... 展开 >> National University Hospital Singapore, Singapore, 119074 收起 <<
NCT00138359 Intestinal Parasitism Not Applicable Terminated - Peru ... 展开 >> Universidad Peruana Cayetano Heredia Lima, Peru 收起 <<

Niclosamide/氯硝柳胺 参考文献

[1]P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19(2):245-95.

[2]Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89-96.

[3]Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 15;22(14):3458-66.

[4]Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9.

[5]Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6.

[6]Xu M, Lee EM, Wen Z, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med. 2016;22(10):1101-1107.

[7]Jiao Y, Chen C, Hu X, et al. Niclosamide and its derivative DK-520 inhibit RANKL-induced osteoclastogenesis. FEBS Open Bio. 2020;10(8):1685-1697. doi:10.1002/2211-5463.12921

Niclosamide/氯硝柳胺 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.28mL

3.06mL

1.53mL

30.57mL

6.11mL

3.06mL

Niclosamide/氯硝柳胺 技术信息

CAS号50-65-7
分子式C13H8Cl2N2O4
分子量 327.12
SMILES Code O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O
MDL No. MFCD00057597
别名 BAY2353; NSC 178296; Clonitralide, Fenasal, BAY 2353, BAY-2353, BAY2353, NSC 178296, NSC178296, NSC-178296, WR-46234, WR46234, WR 46234,; Niclocide
运输蓝冰
InChI Key RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Pubchem ID 4477
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, room temperature

Tags: Niclosamide | 50-65-7 | BAY2353 | BAY 2353 | BAY-2353 | JAK/STAT Signaling | Stem Cell/Wnt | Anti-infection | STAT | Parasite | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Niclosamide/氯硝柳胺 纯度/质量文件 | Niclosamide/氯硝柳胺 亚型比较 | Niclosamide/氯硝柳胺 生物活性 | Niclosamide/氯硝柳胺 细胞研究 | Niclosamide/氯硝柳胺 动物研究 | Niclosamide/氯硝柳胺 临床数据 | Niclosamide/氯硝柳胺 参考文献 | Niclosamide/氯硝柳胺 实验方案 | Niclosamide/氯硝柳胺 技术信息

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