Neostigmine methyl sulfate is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants, but it does not cross the blood-brain barrier.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Neostigmine Methyl Sulfate is acetylcholine esterase inhibitors as neuraxial adjuvant drug. The ED50 and ED95 of epidural neostigmine in combination with PCEA (patient controlled epidural analgesia ) for satisfactory analgesia after partial hepatectomy were 228.63 μg (95% CI = 197.95–299.77 μg) and 300.12 μg (95% CI = 259.44–741.65 μg)[2]. Moreover, the immediate and dramatic reversal of envenomation symptoms following the administration of the anticholinesterase neostigmine methyl sulfate[3]. The N-monophenylcarbamate analogues of neostigmine methyl sulfate have extended duration of cholinesterase inhibition as long-acting agents for myasthenia gravis[4].
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