Naratriptan HCl | 盐酸那拉曲坦 | GR-85548A hydrochloride | 5-HT Receptor Agonist

首页 / 抑制剂/激动剂 / / 5-羟色胺受体 / Naratriptan HCl/那拉曲坦盐酸盐

Naratriptan HCl/那拉曲坦盐酸盐 {[allProObj[0].p_purity_real_show]}

货号：A140046 同义名： 盐酸那拉曲坦 / GR-85548A hydrochloride; Naratriptan (hydrochloride)

Naratriptan HCl is a selective sulfonamide 5-HT1D and 5-HT1B receptor agonist with anti-migraine property .

Naratriptan HCl/那拉曲坦盐酸盐化学结构
CAS号：143388-64-1

Naratriptan HCl/那拉曲坦盐酸盐 3D分子结构
CAS号：143388-64-1

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	1周咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

Naratriptan HCl/那拉曲坦盐酸盐纯度/质量文件产品仅供科研

货号：A140046 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: 更多 >

5-羟色胺受体亚型比较

产品名称	5-HT ↓ ↑	5-HT1 ↓ ↑	5-HT2 ↓ ↑	5-HT3 ↓ ↑	5-HT5 ↓ ↑	5-HT6 ↓ ↑	5-HT7 ↓ ↑	其他靶点	纯度
Desvenlafaxine	++ 5-HT, Ki: 40.2 nM								98%
Lamotrigine	+ 5-HT (human platelets), IC50: 240 μM 5-HT (rat brain synaptosomes), IC50: 474 μM								98%
Venlafaxine	✔								99%
Fluvoxamine maleate	✔								99%
Iloperidone	✔								99%
Ziprasidone HCl	✔								98+%
Atomoxetine HCI	+ 5-HT, Ki: 77 nM								98%
Dapoxetine HCl	✔								97%
Trazodone	✔								98+%
Clomipramine HCl	✔								98%
Mirtazapine	✔								99+%
Escitalopram oxalate	+++ 5-HT, Ki: 0.89 nM								97%
Duloxetine	✔								97%
Sertraline HCl	++ 5-HT, Ki: 13 nM								98%
Citalopram HBr	+++ serotonin reuptake, IC50: 1.8 nM								98%
Latrepirdine 2HCl	✔							GluR	99%
Fluoxetine HCl	✔								99.5%
Paroxetine HCl	✔							AChR	99%
BMY 7378		++ 5-HT1A, pIC50: 6.4 5-HT1D, pIC50: 5.9	+ 5-HT2, pIC50: 5.5						97%
Flibanserin		+++ 5-HT1A, Ki: 1 nM	+ 5-HT2A, Ki: 49 nM						95%
LY310762		+ 5-HT1D, Ki: 249 nM							99%+
Cyclobenzaprine HCI			✔						99%
Blonanserin			+++ 5-HT2, Ki: 3.98 nM						99%
Cyproheptadine HCl			++++ 5-HT2, IC50: 0.6 nM						99+%
Olanzapine			✔						99+%
Pimavanserin hemitartrate			+++ 5-HT2A, pIC50: 8.7						99%
Ketanserin			+++ 5-HT2C (Rat), Ki: 50 nM 5-HT2C (Human), Ki: 2.5 nM						99%+
Loxapine succinate			++ 5-HT2 (bovine), Ki: 6.6 nM 5-HT2 (human), Ki: 6.8 nM						98%
Agomelatine			✔						98%
Clozapine			✔						98%
Amitriptyline			+ 5-HT2, Ki: 235 nM					SERT	99%
PRX-08066 maleate			+++ 5-HT2B, IC50: 3.4 nM						98+%
RS-127445			++++ 5-HT2B, pKi: 9.5 5-HT2B, pIC50: 10.4						99%+
Sarpogrelate HCl			++++ 5-HT2C, Kd: 1.1 nM 5-HT2A, Kd: 2.1 nM						98%
Tropisetron				✔					99%
Ramosetron HCl				++++ 5-HT3 receptor, Ki: 0.091 nM					98%
Ondansetron				✔					99%
Granisetron				✔					98%
Alosetron HCl				✔					98%
Ondansetron HCl dihydrate				✔					98%
VUF10166				++++ 5-HT3AB, Ki: 22 nM 5-HT3A, Ki: 0.04 nM					99%+
Azasetron HCl				++++ 5-HT3, IC50: 0.33 nM					99%
Asenapine maleate		+++ 5-HT1B, pKi: 8.4 5-HT1A, pKi: 8.6	++++ 5-HT2A, pKi: 9.75 5-HT2C, pKi: 10.46		+++ 5-HT5A, pKi: 8.84	++++ 5-HT6, pKi: 9.6	++++ 5-HT7, pKi: 9.94		97%
Risperidone		++ 5-HT1D, Ki: 84.6 nM 5-HT1B, Ki: 14.9 nM	++++ 5-HT2A, Ki: 61.9 nM 5-HT2C, Ki: 12 nM		+ 5-HT5A, Ki: 206 nM		++ 5-HT7, Ki: 6.6 nM		98%
SB 271046 HCl						+++ 5-HT6, pKi: 8.92			99%+
Intepirdine						++++ 5-HT6, pKi: 9.63			99%+
SB-269970 HCl							++ 5-HT7, pKi: 8.3		98+%
BRL 15572		++ 5-HT1D, pKi: 6 5-HT1B, pKi: 6.1	++ 5-HT2A, pKi: 6.6 5-HT2B, pKi: 6.2			+ 5-HT6, pKi: 5.9	+ 5-HT7, pKi: 6.3		95%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Naratriptan HCl/那拉曲坦盐酸盐生物活性

描述

Naratriptan Hydrochloride is a 5-HT1 receptor agonist, which can act on migraine. Naratriptan has high affinity for human recombinant 5HT1B and 5HT1D receptors (pKi = 8.7 +/- 0.03 and 8.3 +/- 0.1, respectively) and causes contractions of dog isolated basilar and middle cerebral artery (EC50 values of 0.11 and 0.07 microM, respectively)^[3]. Naratriptan 2.5–10 mg was superior to placebo for acute migraine treatment in all 6 RCTs(randomised, controlled trials ) in adults, short-term prophylaxis with naratriptan 1 mg b.i.d was superior to placebo for menstruation-associated migraine (MAM)^[4].

Naratriptan HCl/那拉曲坦盐酸盐临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01332500	-		Completed	-	-
NCT01435941	-		Completed	-	-
NCT01332500	-		Completed	-	-

Naratriptan HCl/那拉曲坦盐酸盐参考文献

[1]Prajapati PB, Chotalia J, et al. Development and Validation of Stability-Indicating HPTLC Method for Estimation of Naratriptan Hydrochloride in Its Pharmaceutical Dosage Form and Its Content Uniformity Testing. J Chromatogr Sci. 2016 Aug;54(7):1129-36.

[2]Zhang YP, Trissel LA, Fox JL. Naratriptan hydrochloride in extemporaneosly compounded oral suspensions. Int J Pharm Compd. 2000 Jan-Feb;4(1):69-71.

[3]Connor HE, Feniuk W, Beattie DT, North PC, Oxford AW, Saynor DA, Humphrey PP. Naratriptan: biological profile in animal models relevant to migraine. Cephalalgia. 1997 May;17(3):145-52. doi: 10.1046/j.1468-2982.1997.1703145.x. PMID: 9170336.

[4]Tfelt-Hansen PC. Published and not fully published double-blind, randomised, controlled trials with oral naratriptan in the treatment of migraine: a review based on the GSK Trial Register. J Headache Pain. 2011 Aug;12(4):399-403. doi: 10.1007/s10194-011-0327-3. Epub 2011 Mar 25. PMID: 21437713; PMCID: PMC3139062.

Naratriptan HCl/那拉曲坦盐酸盐实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.44mL

2.69mL

1.34mL

26.89mL

5.38mL

2.69mL

Naratriptan HCl/那拉曲坦盐酸盐技术信息

CAS号	143388-64-1
分子式	C₁₇H₂₆ClN₃O₂S
分子量	371.93
SMILES Code	CN1CCC(C2=CNC3=C2C=C(CCS(=O)(NC)=O)C=C3)CC1.[H]Cl
MDL No.	MFCD08141821

别名	盐酸那拉曲坦 ;GR-85548A hydrochloride; Naratriptan (hydrochloride); Naratriptan hydrochloride
运输	蓝冰
InChI Key	AWEZYKMQFAUBTD-UHFFFAOYSA-N
Pubchem ID	60875

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解方案

动物实验：配制的工作液建议现用现配，短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01332500	-		Completed	-	-
NCT01435941	-		Completed	-	-
NCT01332500	-		Completed	-	-
NCT01381497	-		Completed	-	-
NCT01086358	Workplace Migraine Treatment	Phase 4	Completed	-	United States, Ohio ... 展开 >> Cleveland Clinic, 9500 Euclid Avenue, C-21 Cleveland, Ohio, United States, 44195 收起 <<
NCT00282165	Psychotic Disorders ... 展开 >> Antisocial Personality Disorder Impulse Regulation Disorder Intermittent Explosive Disorder 收起 <<	Phase 4	Terminated(Required number of ... 展开 >>subjects to be included could not be accomplished) 收起 <<	-	Netherlands ... 展开 >> FPC De Kijvelanden Poortugaal, Netherlands, P.O. box 900, 3160AC Rhoon 收起 <<
NCT01381523	-		Completed	-	-
NCT01086358	-		Completed	-	-
NCT03066544	Migraine	Phase 1 Phase 2	Recruiting	June 30, 2020	United States, Connecticut ... 展开 >> Hartford HealthCare Headache Center Recruiting Wethersfield, Connecticut, United States, 06109 Contact: Brooke Pellegrino, PhD 860-696-2925 Brooke.Pellegrino@hhchealth.org Principal Investigator: Brian Grosberg, MD 收起 <<
NCT01059604	-		Completed	-	-
NCT01726920	Migraine Head... 展开 >>ache 收起 <<	Phase 3	Withdrawn(Due to budget limita... 展开 >>tions, the company decided to withdraw this study.) 收起 <<	-	-
NCT01332383	-		Completed	-	-
NCT01390324	Migraine Head... 展开 >>ache 收起 <<	Phase 3	Withdrawn	-	-
NCT00487578	Post Traumatic Headache	Phase 4	Terminated(Terminated October ... 展开 >>2009 (in 4th year) due to low enrollment and anticipated drug expiration November 2009.) 收起 <<	-	United States, Missouri ... 展开 >> Clinvest Springfield, Missouri, United States, 65807 United States, North Carolina Carolinas Rehabilitation, Carolinas HealthCare System Charlotte, North Carolina, United States, 28203 United States, Texas Anodyne Headache and Pain Care Dallas, Texas, United States, 75231 收起 <<
NCT00487578	-		Terminated(Terminated October ... 展开 >>2009 (in 4th year) due to low enrollment and anticipated drug expiration November 2009.) 收起 <<	-	-
NCT01376193	-		Completed	-	-
NCT01161654	Migraine	Not Applicable	Completed	-	United States, Washington ... 展开 >> Charles River Northwest Kinetics Tacoma, Washington, United States, 98418 收起 <<
NCT01161667	Migraine	Not Applicable	Completed	-	United States, Washington ... 展开 >> Charles River Northwest Kinetics Tacoma, Washington, United States, 98418 收起 <<

Naratriptan HCl/那拉曲坦盐酸盐 {[allProObj[0].p_purity_real_show]}

Naratriptan HCl/那拉曲坦盐酸盐纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Naratriptan HCl/那拉曲坦盐酸盐质控信息

Naratriptan HCl/那拉曲坦盐酸盐生物活性

Naratriptan HCl/那拉曲坦盐酸盐临床研究

Naratriptan HCl/那拉曲坦盐酸盐参考文献

Naratriptan HCl/那拉曲坦盐酸盐实验方案

Naratriptan HCl/那拉曲坦盐酸盐技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Naratriptan HCl/那拉曲坦盐酸盐 {[allProObj[0].p_purity_real_show]}

Naratriptan HCl/那拉曲坦盐酸盐 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Naratriptan HCl/那拉曲坦盐酸盐 质控信息

Naratriptan HCl/那拉曲坦盐酸盐 生物活性

Naratriptan HCl/那拉曲坦盐酸盐 临床研究

Naratriptan HCl/那拉曲坦盐酸盐 参考文献

Naratriptan HCl/那拉曲坦盐酸盐 实验方案

Naratriptan HCl/那拉曲坦盐酸盐 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Naratriptan HCl/那拉曲坦盐酸盐纯度/质量文件产品仅供科研

Naratriptan HCl/那拉曲坦盐酸盐质控信息

Naratriptan HCl/那拉曲坦盐酸盐生物活性

Naratriptan HCl/那拉曲坦盐酸盐临床研究

Naratriptan HCl/那拉曲坦盐酸盐参考文献

Naratriptan HCl/那拉曲坦盐酸盐实验方案

Naratriptan HCl/那拉曲坦盐酸盐技术信息