NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared.
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快速发货 顺丰冷链运输,1-2 天到达
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计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.23mL 0.45mL 0.22mL |
11.13mL 2.23mL 1.11mL |
22.25mL 4.45mL 2.23mL |
CAS号 | 1262857-73-7 |
分子式 | C21H19F4N5O2 |
分子量 | 449.4 |
SMILES Code | O=C(NC1=CC=C(F)C([C@]2(C)CO[C@](C(F)(F)F)(C)C(N)=N2)=C1)C3=NC=C(C#N)C=C3C |
MDL No. | N/A |
别名 | |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, inert atmosphere, 2-8°C |