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/ N,N-Diethyl-m-toluamide (DEET)/避蚊胺

N,N-Diethyl-m-toluamide (DEET)/避蚊胺 {[allProObj[0].p_purity_real_show]}

货号：A143062 同义名： N,N-二乙基间甲苯甲酰胺 / Diethyltoluamide; DEET

DEET is the most common active ingredient in insect repellents.

N,N-Diethyl-m-toluamide (DEET)/避蚊胺 化学结构 CAS号：134-62-3
N,N-Diethyl-m-toluamide (DEET)/避蚊胺 化学结构
CAS号：134-62-3
N,N-Diethyl-m-toluamide (DEET)/避蚊胺 3D分子结构
CAS号：134-62-3
N,N-Diethyl-m-toluamide (DEET)/避蚊胺 化学结构 CAS号：134-62-3
N,N-Diethyl-m-toluamide (DEET)/避蚊胺 3D分子结构 CAS号：134-62-3
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N,N-Diethyl-m-toluamide (DEET)/避蚊胺 纯度/质量文件 产品仅供科研

货号：A143062 标准纯度： {[allProObj[0].p_purity_real_show]}
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N,N-Diethyl-m-toluamide (DEET)/避蚊胺 生物活性

描述 DEET, the insect repellent (N,N-diethyl-3-methylbenzamide), is a multimodal compound that acts as a spatial repellent as well as an irritant (contact repellent). When blood was mixed either with 0.1 or 1% DEET, female southern house mosquitoes spent significantly less time feeding than the time spent feeding on blood mixed only with the solvent. DEET, permethrin, and, to a lesser extent, picaridin, act as feeding deterrents[3]. DEET inhibits food ingestion by Drosophila melanogaster flies, and this repellency is mediated by bitter taste neurons in the proboscis. DEET contact chemorepellency is mediated exclusively by the tarsal segments of the legs and not the proboscis[4]. DEET induces favorable repellency against insects by acting on the sensory nervous system. DEET side effects in humans involve new molecular targets including the cholinergic system, acetylcholinesterase (AChE), muscarinic M1 and M3 receptor and the participation of the second messenger nitric oxide (NO)[5].

N,N-Diethyl-m-toluamide (DEET)/避蚊胺 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00938379 Malaria Dengu... 展开 >>e Japanese Encephalitis 收起 << Phase 3 Unknown June 2011 Lao People's Democratic Republ... 展开 >>ic Rural villages in Attepu and Sekong Provinces, Laos PDR Recruiting Pakse, Attepu, Lao People's Democratic Republic Contact: Vanessa Chen-Hussey, MSc    856 (0)21 353 408 ext 116    vanessa.chen-hussey@lshtm.ac.uk    Principal Investigator: Vanessa Chen-Hussey, MSc 收起 <<
NCT02938975 Malaria Phase 3 Not yet recruiting June 2019 Tanzania ... 展开 >> Ifakara Health Institute Not yet recruiting Bagamoyo, Tanzania, 74 Contact: Mercy Nyika    +255788-720602    mnyika@ihi.or.tz    Principal Investigator: Sarah J Moore, PhD          Sub-Investigator: Daniel F Msellemu, MSc 收起 <<

N,N-Diethyl-m-toluamide (DEET)/避蚊胺 参考文献

[1]Flunker LK, Nutter TJ, et al. DEET potentiates the development and persistence of anticholinesterase dependent chronic pain signs in a rat model of Gulf War Illness pain. Toxicol Appl Pharmacol. 2017 Feb 1;316:48-62.

[2]Moody RP, Riedel D, et al. The effect of DEET (N,N-diethyl-m-toluamide) on dermal persistence and absorption of the insecticide fenitrothion in rats and monkeys. J Toxicol Environ Health. 1987;22(4):471-9.

[3]Lu W, Hwang JK, Zeng F, Leal WS. DEET as a feeding deterrent. PLoS One. 2017;12(12):e0189243. Published 2017 Dec 14

[4]Dennis EJ, Goldman OV, Vosshall LB. Aedes aegypti Mosquitoes Use Their Legs to Sense DEET on Contact. Curr Biol. 2019;29(9):1551-1556.e5

[5]Legeay S, Clere N, Apaire-Marchais V, Faure S, Lapied B. Unusual modes of action of the repellent DEET in insects highlight some human side effects. Eur J Pharmacol. 2018;825:92-98

N,N-Diethyl-m-toluamide (DEET)/避蚊胺 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.23mL

1.05mL

0.52mL

26.14mL

5.23mL

2.61mL

52.28mL

10.46mL

5.23mL

N,N-Diethyl-m-toluamide (DEET)/避蚊胺 技术信息

CAS号134-62-3
分子式C12H17NO
分子量 191.27
SMILES Code CCN(CC)C(=O)C1=CC(C)=CC=C1
MDL No. MFCD00009046
别名 N,N-二乙基间甲苯甲酰胺 ;Diethyltoluamide; DEET; NSC 33840; N,N-Diethyl-m-toluamide
运输蓝冰
InChI Key MMOXZBCLCQITDF-UHFFFAOYSA-N
Pubchem ID 4284
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Tags: Diethyltoluamide | 134-62-3 | DEET | N,N-Diethyl-m-toluamide | Anti-infection | Parasite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | N,N-Diethyl-m-toluamide (DEET)/避蚊胺 纯度/质量文件 | N,N-Diethyl-m-toluamide (DEET)/避蚊胺 生物活性 | N,N-Diethyl-m-toluamide (DEET)/避蚊胺 临床数据 | N,N-Diethyl-m-toluamide (DEET)/避蚊胺 参考文献 | N,N-Diethyl-m-toluamide (DEET)/避蚊胺 实验方案 | N,N-Diethyl-m-toluamide (DEET)/避蚊胺 技术信息

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