Moroxydine HCl is an antiviral drug used to treat influenza, active against RNA and DNA viruses. It is also an inhibitor of PTP1B and TCPTP inhibitor with IC50 values of 80-160 nM.
H-Moroxydine hydrochloride (ABOB hydrochloride) is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines. It has potential applications against a number of RNA and DNA viruses[3]. At the concentration of 40μgmL-1, Mor (Moroxydine Hydrochloride) and Rib (ribavirin) had a significant protective effect on virus-infected cells. Moreover, the gene expressions of vp5, vp6 and NS66 were significantly inhibited by treatment with Mor or Rib, especially gene expression of the vp5. Mor and Rib as antiviral compounds are effective for the control of GCRV replication and the indirectly regulation of cellular immune response[4]. Moreover, exposing GCRV-infected cell to 6.3 μg mL(-1) of Mor for 96 h avoid ca. 50% apoptosis. Mor blocked the GCRV-induced cytopathic effects and eliminated nucleocapsids in CIK cells to keep the normal morphological structure[5].
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