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/ 微管 / Monomethyl auristatin E/一甲基澳瑞他汀 E

Monomethyl auristatin E/一甲基澳瑞他汀 E {[allProObj[0].p_purity_real_show]}

货号：A172961 同义名： MMAE; Vedotin

MMAE can inhibit tubulin polymerization used in ADCs.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Monomethyl auristatin E/一甲基澳瑞他汀 E 化学结构 CAS号：474645-27-7
Monomethyl auristatin E/一甲基澳瑞他汀 E 化学结构
CAS号：474645-27-7
Monomethyl auristatin E/一甲基澳瑞他汀 E 3D分子结构
CAS号：474645-27-7
Monomethyl auristatin E/一甲基澳瑞他汀 E 化学结构 CAS号：474645-27-7
Monomethyl auristatin E/一甲基澳瑞他汀 E 3D分子结构 CAS号：474645-27-7
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Monomethyl auristatin E/一甲基澳瑞他汀 E 纯度/质量文件 产品仅供科研

货号：A172961 标准纯度： {[allProObj[0].p_purity_real_show]}
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Monomethyl auristatin E/一甲基澳瑞他汀 E 生物活性

描述 Monomethyl auristatin E (MMAE) produced under Good Manufacturing Practice (GMP) guidelines is a version of MMAE that inhibits tubulin polymerization[1].

Monomethyl auristatin E/一甲基澳瑞他汀 E 动物研究

Animal study The combination of Monomethyl auristatin E (MMAE) with ionizing radiation (IR) leads to delayed tumor growth, whereas the use of tumor-targeting ACPP-cRGD-MMAE alongside IR results in a more pronounced and prolonged regression of tumors in xenograft models[2].

Monomethyl auristatin E/一甲基澳瑞他汀 E 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02227199 Recurrent Adult Hodgkin Lympho... 展开 >>ma Refractory Hodgkin Lymphoma TNFRSF8 Positive 收起 << Phase 1 Phase 2 Recruiting - United States, Washington ... 展开 >> Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Ajay K. Gopal    206-606-2037    agopal@u.washington.edu    Principal Investigator: Ajay K. Gopal 收起 <<
NCT00866047 - Completed - -
NCT02001623 Ovary Cancer ... 展开 >>Cervix Cancer Endometrium Cancer Bladder Cancer Prostate Cancer (CRPC) Esophagus Cancer Lung Cancer(NSCLC) Squamous Cell Carcinoma of the Head and Neck (SCCHN) 收起 << Phase 1 Phase 2 Active, not recruiting December 2018 -

Monomethyl auristatin E/一甲基澳瑞他汀 E 参考文献

[1]Yang SY, Li LL. The purposes of 5H- [1,2,4] triazine [5,6-b] indole derivatives of 3 substitutions. CN108309982A. 2017.

[2]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.

Monomethyl auristatin E/一甲基澳瑞他汀 E 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.39mL

0.28mL

0.14mL

6.96mL

1.39mL

0.70mL

13.93mL

2.79mL

1.39mL

Monomethyl auristatin E/一甲基澳瑞他汀 E 技术信息

CAS号474645-27-7
分子式C39H67N5O7
分子量 717.98
SMILES Code O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](NC)C(C)C)=O)=O)=O)OC)=O
MDL No. MFCD22124498
别名 MMAE; Vedotin; Brentuximab vedotin; SGD-1010
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, sealed in dry, 2-8°C

Tags: Monomethyl auristatin E | MMAE;Vedotin;Brentuximab vedotin;SGD-1010 | Microtubule/Tubulin | AmBeed-信号通路专用抑制剂 | Monomethyl auristatin E/一甲基澳瑞他汀 E 纯度/质量文件 | Monomethyl auristatin E/一甲基澳瑞他汀 E 生物活性 | Monomethyl auristatin E/一甲基澳瑞他汀 E 动物研究 | Monomethyl auristatin E/一甲基澳瑞他汀 E 临床数据 | Monomethyl auristatin E/一甲基澳瑞他汀 E 参考文献 | Monomethyl auristatin E/一甲基澳瑞他汀 E 实验方案 | Monomethyl auristatin E/一甲基澳瑞他汀 E 技术信息

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