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/ Minoxidil/敏乐啶

Minoxidil/敏乐啶 {[allProObj[0].p_purity_real_show]}

货号：A141385 同义名： 米诺地尔 / U10858; Loniten

Minoxidil is an antihypertensive vasodilator medication.

Minoxidil/敏乐啶 化学结构 CAS号：38304-91-5
Minoxidil/敏乐啶 化学结构
CAS号：38304-91-5
Minoxidil/敏乐啶 3D分子结构
CAS号：38304-91-5
Minoxidil/敏乐啶 化学结构 CAS号：38304-91-5
Minoxidil/敏乐啶 3D分子结构 CAS号：38304-91-5
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Minoxidil/敏乐啶 纯度/质量文件 产品仅供科研

货号：A141385 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Potassium Channel ↓ 其他靶点 纯度
Tolbutamide ✔ 98%
Glimepiride ++++

SUR1, IC50: 5.4 nM

SUR2B, IC50: 7.3 nM

 		97%
Dronedarone HCl ✔ 95%
Gliquidone ++

Potassium channel, IC50: 27.2 nM

 		99%
TRAM-34 +++

IKCa1 (KCa3.1), Kd: 20 nM

 		98%
Glibenclamide ✔ 98%
Amiodarone HCl ✔ 97%
Gliclazide ++

Potassium channel, IC50: 184 nM

 		98%
Repaglinide ✔ 98%
Dofetilide ✔ 98%
Nateglinide ✔ 99%
Quinine HCl dihydrate ✔ 98%
ML133 HCl +

Kir2.1, IC50: 290 nM

 		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Minoxidil/敏乐啶 生物活性

描述 Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM. Minoxidil (0.01 mmoL/kg body weight; intraperitoneal injection; for 3.5 hours; fisher 344 rats) treatment inhibits carrageenan-induced rat paw oedema with an inhibitory potency (49%)[3]. Minoxidil induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation in epidermal cells. In addition, two morphologically distinct cell types appeared[4]. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes and it is also a vasodilator, by widening blood vessels and opening potassium channels, it allows more oxygen, blood and nutrients to the follicle. This can also cause follicles in the telogen phase to shed, usually soon to be replaced by new, thicker hairs in a new anagen phase. The most common adverse reactions of the topical formulation are limited to irritant and allergic contact dermatitis on the scalp[5].

Minoxidil/敏乐啶 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00283686 Kidney, Polycystic Phase 3 Completed - United States, Colorado ... 展开 >> University of Colorado Health Sciences Center Denver (Aurora), Colorado, United States, 800045 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Tufts University-New England Medical Center Boston, Massachusetts, United States, 02111 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 收起 <<
NCT00283686 - Completed - -
NCT01227031 - Unknown July 2011 Taiwan ... 展开 >> Taipei Medical University-Wan Fang Hospital Not yet recruiting Taipei, Taiwan Contact: Ren-Yu Tsai    886-2-29307930 ext 2980    b671022@tmu.edu.tw 收起 <<

Minoxidil/敏乐啶 参考文献

[1]Grice JE, Ciotti S, et al. Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci. 2010 Feb;99(2):712-8.

[2]Grice JE, Ciotti S, et al. Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci. 2010 Feb;99(2):712-8.

[3]Hadjipavlou-Litina D, Magoulas GE, Bariamis SE, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013;95(7):1437-1449

[4]Cohen RL, Alves ME, Weiss VC, West DP, Chambers DA. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984;82(1):90-93

[5]Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Minoxidil use in dermatology, side effects and recent patents. Recent Pat Inflamm Allergy Drug Discov. 2012;6(2):130-136

Minoxidil/敏乐啶 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.78mL

0.96mL

0.48mL

23.89mL

4.78mL

2.39mL

47.79mL

9.56mL

4.78mL

Minoxidil/敏乐啶 技术信息

CAS号38304-91-5
分子式C9H15N5O
分子量 209.25
SMILES Code NC1=NC(N2CCCCC2)=CC(N)=[N+]1[O-]
MDL No. MFCD00063409
别名 米诺地尔 ;U10858; Loniten; Minoxidil, Loniten, Rogaine, U 10858
运输蓝冰
InChI Key ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Pubchem ID 4201
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, room temperature
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

Tags: Minoxidil | U10858;Loniten;Minoxidil, Loniten, Rogaine, U 10858 | 米诺地尔 | Depressurization | Other Compounds | Potassium Channel | AmBeed-信号通路专用抑制剂 | Minoxidil/敏乐啶 纯度/质量文件 | Minoxidil/敏乐啶 亚型比较 | Minoxidil/敏乐啶 生物活性 | Minoxidil/敏乐啶 临床数据 | Minoxidil/敏乐啶 参考文献 | Minoxidil/敏乐啶 实验方案 | Minoxidil/敏乐啶 技术信息

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