Miconazole is a synthetic imidazole-derived antifungal used in the treatment of candidal skin infections, selectively affecting the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes.
Miconazole is an imidazole antifungal agent. This agent is distinguished from other azoles by possessing two mechanisms of action. The first mechanism is shared with other azoles and involves the inhibition of ergosterol synthesis. Another mechanism involves inhibition of peroxidases, which results in the accumulation of peroxide within the cell resulting in cell death. Miconazole remains a highly prescribed treatment for vaginal candidiasis[3]. Miconazole was more effective than nystatin for thrush. For HIV-infected patients, there was no significant difference in the efficacy between miconazole and other antifungals. For denture wearers, microwave therapy was significantly better than miconazole. No significant difference was found in the safety evaluation between miconazole and other treatments[4]. In addition, miconazole promoted functional recovery on ischemic stroke model via stimulating post-ischemic neurogenesis[5].
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