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Maytansine {[allProObj[0].p_purity_real_show]}

货号：A655828 同义名： NSC 153858; Maitansine

Maitansine is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.

Maytansine 化学结构 CAS号：35846-53-8
Maytansine 化学结构
CAS号：35846-53-8
Maytansine 3D分子结构
CAS号：35846-53-8
Maytansine 化学结构 CAS号：35846-53-8
Maytansine 3D分子结构 CAS号：35846-53-8
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Maytansine 纯度/质量文件 产品仅供科研

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Maytansine 生物活性

描述 Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles[3]. Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell[4]. Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations[5]. Maytansine, a potent inhibitor of mitosis and in vitro microtubule assembly, was used to demonstrate a striking difference in the mechanism by which two of the main groups of brain microtubule-associated proteins, Tau and MAP2, interact with tubulin. At the low concentrations of 0.5 to 2 mM, maytansine inhibited Tau-catalyzed tubulin assembly more effectively than it did MAP2-catalyzed assembly[6]. Maytansine, at 6x10-8 M, irreversibly inhibits cell division in eggs of sea urchins and clams. Maytansine causes the disappearance of a mitotic apparatus or prevents one from forming if added at early stages. Maytansine inhibits in vitro polymerization of tubulin[7].

Maytansine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02318901 - Terminated(PI no longer at sig... 展开 >>ht. Results not collected) 收起 << - -
NCT02318901 Advanced Cancer ... 展开 >> Breast Cancer Gastric Cancer Esophageal Cancer Colorectal Cancer 收起 << Phase 1 Phase 2 Terminated(PI no longer at sig... 展开 >>ht. Results not collected) 收起 << - United States, Arizona ... 展开 >> Western Regional Medical Center/Cancer Treatment Center of America Goodyear, Arizona, United States, 85338 收起 <<
NCT02465060 Advanced Malignant Solid Neopl... 展开 >>asm Bladder Carcinoma Breast Carcinoma Cervical Carcinoma Colon Carcinoma Colorectal Carcinoma Endometrial Carcinoma Esophageal Carcinoma Gastric Carcinoma Glioma Head and Neck Carcinoma Kidney Carcinoma Liver and Intrahepatic Bile Duct Carcinoma Lung Carcinoma Lymphoma Malignant Uterine Neoplasm Melanoma Ovarian Carcinoma Pancreatic Carcinoma Plasma Cell Myeloma Prostate Carcinoma Rectal Carcinoma Recurrent Bladder Carcinoma Recurrent Breast Carcinoma Recurrent Cervical Carcinoma Recurrent Colon Carcinoma Recurrent Colorectal Carcinoma Recurrent Esophageal Carcinoma Recurrent Gastric Carcinoma Recurrent Glioma Recurrent Head and Neck Carcinoma Recurrent Liver Carcinoma Recurrent Lung Carcinoma Recurrent Lymphoma Recurrent Malignant Solid Neoplasm Recurrent Melanoma Recurrent Ovarian Carcinoma Recurrent Pancreatic Carcinoma Recurrent Plasma Cell Myeloma Recurrent Prostate Carcinoma Recurrent Rectal Carcinoma Recurrent Skin Carcinoma Recurrent Thyroid Gland Carcinoma Recurrent Uterine Corpus Carcinoma Refractory Lymphoma Refractory Malignant Solid Neoplasm Refractory Plasma Cell Myeloma Skin Carcinoma Thyroid Gland Carcinoma Uterine Corpus Cancer 收起 << Phase 2 Recruiting - -

Maytansine 参考文献

[1]Kusari S, Lamshoft M, et al. Endophytes are hidden producers of maytansine in Putterlickia roots. J Nat Prod. 2014 Dec 26;77(12):2577-84.

[2]Tang X, Dai H, et al. Maytansine-loaded star-shaped folate-core PLA-TPGS nanoparticles enhancing anticancer activity. Am J Transl Res. 2014 Oct 11;6(5):528-37. eCollection 2014.

[3]Melissa K Gardner,et al. Microtubule catastrophe and rescue. Curr Opin Cell Biol. 2013 Feb;25(1):14-22.

[4] Holly V Goodson,et al. Microtubules and Microtubule-Associated Proteins. Cold Spring Harb Perspect Biol.2018 Jun 1;10(6):a022608.

[5]Lopus M, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010;9(10):2689-2699.

[6] A Fellous,et al. Effects of Tau and MAP2 on the interaction of maytansine with tubulin: inhibitory effect of maytansine on vinblastine-induced aggregation of tubulin. Cancer Res. 1985 Oct;45(10):5004-10.

[7]Remillard S, et al. Antimitotic activity of the potent tumor inhibitor maytansine. Science. 1975;189(4207):1002-1005.

Maytansine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.44mL

0.29mL

0.14mL

7.22mL

1.44mL

0.72mL

14.45mL

2.89mL

1.44mL

Maytansine 技术信息

CAS号35846-53-8
分子式C34H46ClN3O10
分子量 692.2
SMILES Code C[C@@]12[C@@H](O2)[C@H](C)[C@]([H])(C[C@](N3)(O)[C@]([H])(OC)/C=C/C=C(CC4=CC(N(C(C[C@@]1(OC([C@@H](N(C(C)=O)C)C)=O)[H])=O)C)=C(Cl)C(OC)=C4)\C)OC3=O
MDL No. MFCD28127038
别名 NSC 153858; Maitansine; Mertansine.; DM-1; Maitansinum; Maitansina
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Maytansine | 35846-53-8 | NSC 153858 | NSC153858 | NSC-153858 | Microtubule/Tubulin Inhibitor | Cell Cycle/DNA Damage | Cytoskeleton | Microtubule/Tubulin | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Maytansine 纯度/质量文件 | Maytansine 生物活性 | Maytansine 临床数据 | Maytansine 参考文献 | Maytansine 实验方案 | Maytansine 技术信息

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