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Aurora Kinase
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/ Maleic Acid/马来酸

Maleic Acid/马来酸 {[allProObj[0].p_purity_real_show]}

货号：A492718 同义名： 顺丁烯二酸

Maleic acid is used in the synthesis of pyridoindolones as potent inhibitors of Aurora kinases. It is a reagent in the preparation of TiO2/carbon nanotube composites.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
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Maleic Acid/马来酸 化学结构 CAS号：110-16-7
Maleic Acid/马来酸 化学结构
CAS号：110-16-7
Maleic Acid/马来酸 3D分子结构
CAS号：110-16-7
Maleic Acid/马来酸 化学结构 CAS号：110-16-7
Maleic Acid/马来酸 3D分子结构 CAS号：110-16-7
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Maleic Acid/马来酸 纯度/质量文件 产品仅供科研

货号：A492718 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

更多 >
产品名称 Aurora A ↓ Aurora B ↓ Aurora C ↓ 其他靶点 纯度
BI-847325 ++

Aurora A (Human), IC50: 25 nM

 		++++

Aurora B (Xenopus laevis), IC50: 3 nM

 		++

Aurora C (Human), IC50: 15 nM

 		99%+
CCT 137690 ++

Aurora A, IC50: 15 nM

 		++

Aurora B, IC50: 25 nM

 		++

Aurora C, IC50: 19 nM

 		99%+
MK-5108 ++++

Aurora A, IC50: 0.064 nM

 		99%+
KW-2449 +

Aurora A, IC50: 48 nM

 		FLT3 99%+
Tozasertib ++++

Aurora A, Ki app: 0.6 nM

 		++

Aurora B, Ki app: 18 nM

 		+++

Aurora C, Ki app: 4.6 nM

 		Bcr-Abl,FLT3 99%+
AT9283 ++++

Aurora A, IC50: ~3.0 nM

 		++++

Aurora B, IC50: ~3.0 nM

 		99%+
MLN8054 +++

Aurora A, IC50: 4 nM

 		+

Aurora B, IC50: 172 nM

 		99%+
ZM-447439 +

Aurora A, IC50: 110 nM

 		+

Aurora B, IC50: 130 nM

 		Src 99%+
TCS7010 ++++

Aurora A, IC50: 3.4 nM

 		99%+
TAK-901 ++

Aurora A-TPX2, IC50: 21 nM

 		++

Aurora B-INCENP, IC50: 15 nM

 		99%+
Danusertib +++

Aurora A, IC50: 13 nM

 		+

Aurora B, IC50: 79 nM

 		+

Aurora C, IC50: 61 nM

 		RET 99%+
MK-8745 ++++

Aurora A, IC50: 0.6 nM

 		99+%
PHA-680632 ++

Aurora A, IC50: 27 nM

 		+

Aurora B, IC50: 135 nM

 		+

Aurora C, IC50: 120 nM

 		FLT3 99%+
AMG 900 +++

Aurora A, IC50: 5 nM

 		+++

Aurora B, IC50: 4 nM

 		++++

Aurora C, IC50: 1 nM

 		99%+
Alisertib ++++

Aurora A, IC50: 1.2 nM

 		99%+
ENMD-2076 +++

Aurora A, IC50: 14 nM

 		+

Aurora B, IC50: 350 nM

 		FLT3,RET 98%
JNJ-7706621 +++

Aurora A, IC50: 11 nM

 		++

Aurora B, IC50: 15 nM

 		99%+
CYC-116 +++

Aurora A, Ki: 8 nM

 		+++

Aurora B, Ki: 9 nM

 		FLT3 99%+
Reversine +++

Aurora A, IC50: 12 nM

 		+++

Aurora B, IC50: 13 nM

 		++

Aurora C, IC50: 20 nM

 		98%
CCT129202 ++

Aurora A, IC50: 42 nM

 		+

Aurora B, IC50: 198 nM

 		+

Aurora C, IC50: 227 nM

 		98%
SNS-314 mesylate +++

Aurora A, IC50: 9 nM

 		++

Aurora B, IC50: 31 nM

 		++++

Aurora C, IC50: 3 nM

 		99%+
Barasertib-HQPA ++++

Aurora B, IC50: 0.37 nM

 		99%+
Hesperadin +

Aurora B (human), IC50: 250 nM

 		98%
GSK-1070916 ++++

Aurora B-INCENP, IC50: 3.5 nM

 		+++

Aurora C-INCENP, IC50: 6.5 nM

 		Tie-2,SIK 99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Maleic Acid/马来酸 生物活性

描述 Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[3]. Maleic acid affected the extracellular GABA levels while it did not affect the intracellular ones. Maleic acid had a major impact mainly on GadD2 activity as also shown in cell lysates. Furthermore, it was demonstrated that maleic acid is able to partly remove biofilms of L. monocytogenes. Maleic acid is able to inhibit the GAD of L. monocytogenes significantly enhancing its sensitivity to acidic conditions and together with its ability to remove biofilms[4]. Maleic acid induced concentration-dependent and time-dependent cell death shown by increased lactate dehydrogenase release as well as ethidium homodimer and calcein acetoxymethyl ester staining. MA (Maleic acid) toxicity was critically dependent on calcium levels in culture medium and blocked by the extra- and intracellular calcium chelators EGTA and BAPTA-AM respectively. Moreover, MA-induced cell death was associated with activation of calcium-dependent calpain proteases[5]. MA induced proteinuria, an increase in urinary excretion of N-acetyl-β-d-glucosaminidase, and a decrease in plasma glutathione peroxidase activity, renal blood flow, and oxygenation and perfusion of renal cortex. Moreover, MA impaired mitochondrial bioenergetics associated to complex I, mitochondrial membrane potential and respiratory control index and increased the mitochondrial production of hydrogen peroxide[6].

Maleic Acid/马来酸 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02731287 Hemangioma Phase 2 Completed - Spain ... 展开 >> Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Hospital Virgen del Rocío Sevilla, Spain, 41013 收起 <<
NCT01873131 Hemangioma Not Applicable Recruiting December 2020 United States, Massachusetts ... 展开 >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Thanh Nga T Tran, MD PhD    617-724-4937    ttran2@partners.org    Contact: Ray H Jalian, MD    617 724-4937    hjalian@partners.org    Principal Investigator: R. Rox Anderson, MD          Sub-Investigator: Thanh Nga T Tran, MD PhD          Sub-Investigator: Kelly Stankiewicz, MD          Sub-Investigator: Ray H Jalian, MD 收起 <<
NCT02207621 Ocular Hypertension ... 展开 >> Open-angle Glaucoma 收起 << Phase 3 Completed - United States, New Jersey ... 展开 >> Aerie Pharmaceuticals Bedminster, New Jersey, United States, 07921 收起 <<

Maleic Acid/马来酸 参考文献

[1]El-Sakhawy F, Kassem H, et al. Phytochemical investigation of the bioactive extracts of the leaves of Ficus cyathistipula Warb. Z Naturforsch C. 2016;71(5-6):141-54.

[2]El Sayed AM, Ezzat SM, Sabry OM. A new antibacterial lupane ester from the seeds of Acokanthera oppositifolia Lam. Nat Prod Res. 2016 Apr 4:1-6.

[3]Fonda ML. Glutamate decarboxylase. Substrate specificity and inhibition by carboxylic acids. Biochemistry. 1972 Mar 28;11(7):1304-9

[4]Paudyal R, Barnes RH, Karatzas KAG. A novel approach in acidic disinfection through inhibition of acid resistance mechanisms; Maleic acid-mediated inhibition of glutamate decarboxylase activity enhances acid sensitivity of Listeria monocytogenes. Food Microbiol. 2018 Feb;69:96-104

[5]Tuncel AT, Ruppert T, Wang BT, Okun JG, Kölker S, Morath MA, Sauer SW. Maleic Acid--but Not Structurally Related Methylmalonic Acid--Interrupts Energy Metabolism by Impaired Calcium Homeostasis. PLoS One. 2015 Jun 18;10(6):e0128770

[6]Briones-Herrera A, Avila-Rojas SH, Aparicio-Trejo OE, Cristóbal M, León-Contreras JC, Hernández-Pando R, Pinzón E, Pedraza-Chaverri J, Sánchez-Lozada LG, Tapia E. Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress. Food Chem Toxicol. 2018 May;115:185-197

Maleic Acid/马来酸 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

8.62mL

1.72mL

0.86mL

43.08mL

8.62mL

4.31mL

86.15mL

17.23mL

8.62mL

Maleic Acid/马来酸 技术信息

CAS号110-16-7
分子式C4H4O4
分子量 116.07
SMILES Code O=C(O)/C=C\C(O)=O
MDL No. MFCD00063177
别名 顺丁烯二酸
运输蓝冰
InChI Key VZCYOOQTPOCHFL-UPHRSURJSA-N
Pubchem ID 444266
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

Tags: Maleic Acid | 顺丁烯二酸 | Aliphatic Acyl | Aurora Kinase | AmBeed-信号通路专用抑制剂 | Maleic Acid/马来酸 纯度/质量文件 | Maleic Acid/马来酸 亚型比较 | Maleic Acid/马来酸 生物活性 | Maleic Acid/马来酸 临床数据 | Maleic Acid/马来酸 参考文献 | Maleic Acid/马来酸 实验方案 | Maleic Acid/马来酸 技术信息

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