Lupeol/羽扇豆醇
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货号：A813209
同义名：
Monogynol B; Fagarasterol
Lupeol, a natural product isolated and purified from the flower of Chrysanthemum morifolium, has potential anticancer effect against hepatocellular and pancreatic cancer, by inhibiting cell proliferation, inducing apoptosis and blocking Akt/PI3K and Wnt signaling pathway.
Lupeol/羽扇豆醇 化学结构
Lupeol/羽扇豆醇 3D分子结构
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现货
1周
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Lupeol/羽扇豆醇 纯度/质量文件 产品仅供科研
货号：A813209
标准纯度：
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Lupeol/羽扇豆醇 质控信息
Cyproterone acetate
++++
Androgen Receptor, IC50: 7.1 nM
98%
Apalutamide
+++
Androgen Receptor, IC50: 16 nM
98%
AZD3514
+
Androgen Receptor, Ki: 2.2 μM
99%
Darolutamide
++++
Androgen receptor, Ki: 11 nM
98%
Flutamide
+++
Androgen Receptor, Ki: 55 nM
98%
Galeterone
++
Androgen Receptor, IC50: 384 nM
98%
Enzalutamide
+++
Androgen Receptor, IC50: 36 nM
98%
Megestrol
✔
98%
Bicalutamide
++
Androgen Receptor, IC50: 0.16 μM
99%
EPI-001
+
Androgen Receptor, IC50: ~6 μM
98%
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Lupeol/羽扇豆醇 生物活性
描述
Lupeol is a pentacyclic triterpene found in various species in the plant kingdom with anti-inflammatory, antioxidant, anti-diabetic, and anti-mutagenic effects. In vitro , lupeol at 10 µg/mL and 20 µg/mL, significantly inhibited keratinocyte proliferation by 53% and 64%, respectively, after 24 h treatment. Additionally, in keratinocytes, lupeol treatment resulted in the activation of Akt, p38, and Tie-2[4] In vivo , lupeol decrease serum prostate-specific antigen levels and inhibit the tumorigenicity of prostate cancer (CaP) cells[5]
Lupeol/羽扇豆醇 参考文献
[1] Zhang L, Tu Y, et al. A novel mechanism of hepatocellular carcinoma cell apoptosis induced by lupeol via Brain-Derived Neurotrophic Factor Inhibition and Glycogen Synthase Kinase 3 beta reactivation. Eur J Pharmacol. 2015 Sep 5;762:55-62.
[2] Jin Y, Lyu Y, et al. Lupeol enhances radiosensitivity of human hepatocellular carcinoma cell line SMMC-7721 in vitro and in vivo. Int J Radiat Biol. 2015 Feb;91(2):202-8.
[3] Saleem M. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett. 2009;285(2):109-115.
[4] Pereira Beserra F, Xue M, Maia GLA, Leite Rozza A, Helena Pellizzon C, Jackson CJ. Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways. Molecules. 2018 Oct 30;23(11):2819. doi: 10.3390/molecules23112819. PMID: 30380745; PMCID: PMC6278408.
[5] Saleem M, Murtaza I, Tarapore RS, Suh Y, Adhami VM, Johnson JJ, Siddiqui IA, Khan N, Asim M, Hafeez BB, Shekhani MT, Li B, Mukhtar H. Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling. Carcinogenesis. 2009 May;30(5):808-17. doi: 10.1093/carcin/bgp044. Epub 2009 Feb 20. PMID: 19233958; PMCID: PMC2722146.
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Lupeol/羽扇豆醇 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.34mL
0.47mL
0.23mL
11.72mL
2.34mL
1.17mL
23.43mL
4.69mL
2.34mL
Lupeol/羽扇豆醇 技术信息
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