Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究 抗生素和抗病毒
/
抗感染
小分子阳性药 功能
/
驱虫剂
神经递质 Antiparasitic
/ Lumefantrine/苯芴醇

Lumefantrine/苯芴醇 {[allProObj[0].p_purity_real_show]}

货号：A846348 同义名： 本芴醇 / Benflumetol; CPG-56695

Lumefantrine is an antimalarial drug only used in combination with Artemether to treat acute uncomplicated malaria. Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr; IC50 = 8.1 µM).

Lumefantrine/苯芴醇 化学结构 CAS号：82186-77-4
Lumefantrine/苯芴醇 化学结构
CAS号：82186-77-4
Lumefantrine/苯芴醇 3D分子结构
CAS号：82186-77-4
Lumefantrine/苯芴醇 化学结构 CAS号：82186-77-4
Lumefantrine/苯芴醇 3D分子结构 CAS号：82186-77-4
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Lumefantrine/苯芴醇 纯度/质量文件 产品仅供科研

货号：A846348 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

更多 >

Lumefantrine/苯芴醇 生物活性

描述 Lumefantrine is an antimalarial drug, used in combination with Artemether. artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs, respectively[3]. The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Lumefantrine exposure decreased with increasing pre-treatment parasitaemia, and the dose limitation on absorption of lumefantrine was substantial. Simulations using the lumefantrine pharmacokinetic model suggest that, in young children and pregnant women beyond the first trimester, lengthening the dose regimen (twice daily for 5 days) and, to a lesser extent, intensifying the frequency of dosing (3 times daily for 3 days) would be more efficacious than using higher individual doses in the current standard treatment regimen (twice daily for 3 days) [4]. Artemether-lumefantrine is often coadministered with efavirenz-based antiretroviral therapy for malaria treatment in HIV-infected women during pregnancy. Overall, pregnancy tempered the extent of efavirenz-lumefantrine interactions, resulting in increased lumefantrine exposure[5].

Lumefantrine/苯芴醇 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00164710 Malaria, Falciparum Phase 4 Completed - Malawi ... 展开 >> Kawale Health Center Lilongwe, Lilongwe District, Malawi Machinga District Hospital Liwonde, Machinga District, Malawi Matiki Health Center Dwangwa, Nkhotakota District, Malawi 收起 <<
NCT00541385 Malaria Phase 3 Completed - Burkina Faso ... 展开 >> Centre National de Recherche et de Formation sur le Paludisme Ouagadougou, Burkina Faso Congo Ecole de Santé Publique, Faculté de Médecine, Université de Kinshasa Kinshasa, DRC, Congo Côte D'Ivoire Unité de Paludologie de l'Institut Pasteur d'Abidjan Abdijan, Côte D'Ivoire Gabon Medical Research Unit, Albert Schweitzer Hospital Lambaréné, Gabon Kenya Siaya District Hospital, Medical Superintendent's office Siaya Town, Kenya Mali Malaria Research and Training Center, Faculté de Médecine, de Pharmacie et d'Ondonto-stomatologie Bamako, Mali Mozambique Instituto Nacional de Saude, Ministero de Saude Maputo, Mozambique Philippines Puerto Princesa General Hospital Puerto Princesa, Philippines 收起 <<
NCT00484900 Plasmodium Falciparum Malaria Phase 3 Completed - Cameroon ... 展开 >> Cameroon Baptist Convention Clinic of Biyem-Assi Yaounde, Cameroon Mali Health centres of Samako, Kolle and Bancoumane Bamako, Mali Rwanda Health centres Rwamagana and Muhima Kigali, Rwanda Sudan Alhara Alola Health centre New Halfa, Sudan 收起 <<

Lumefantrine/苯芴醇 参考文献

[1]Ndounga M, Pembe Issamou Mayengue, et al. Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study. Malar J. 2015 Oct 29;14(1):423.

[2]Mutabingwa TK, Anthony D, et al. Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. Lancet. 2005 Apr 23-29;365(9469):1474-80.

[3]Ndounga M, Pembe Issamou Mayengue, Casimiro PN, et al. Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study. Malar J. 2015;14:423. Published 2015 Oct 29

[4]Kloprogge F, Workman L, Borrmann S, et al. Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis. PLoS Med. 2018;15(6):e1002579. Published 2018 Jun 12

[5]Adegbola A, Abutaima R, Olagunju A, et al. Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection. Antimicrob Agents Chemother. 2018;62(10):e01252-18. Published 2018 Sep 24

Lumefantrine/苯芴醇 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.45mL

1.89mL

0.95mL

18.91mL

3.78mL

1.89mL

Lumefantrine/苯芴醇 技术信息

CAS号82186-77-4
分子式C30H32Cl3NO
分子量 528.94
SMILES Code ClC1=CC=C(C=C1)/C=C2C3=C(C4=C\2C=C(Cl)C=C4)C(C(O)CN(CCCC)CCCC)=CC(Cl)=C3
MDL No. MFCD05662268
别名 本芴醇 ;Benflumetol; CPG-56695; HSDB 7210
运输蓝冰
InChI Key DYLGFOYVTXJFJP-MYYYXRDXSA-N
Pubchem ID 6437380
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Lumefantrine | 82186-77-4 | Benflumetol | Parasite | Parasite Inhibitor | Anti-infection | Autophagy | Parasite | Autophagy | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Lumefantrine/苯芴醇 纯度/质量文件 | Lumefantrine/苯芴醇 生物活性 | Lumefantrine/苯芴醇 临床数据 | Lumefantrine/苯芴醇 参考文献 | Lumefantrine/苯芴醇 实验方案 | Lumefantrine/苯芴醇 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z