货号:A132651
同义名:
Lithospermic Acid A; (+)-Lithospermic Acid
Lithospermic acid is a natural product isolated and purified from the roots of Lithospermum ruderale with anti-HIV, anti-gonadotrophic and anti-thyroidal effects, and is a cardiotonic agent.
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描述 | Lithospermic acid is a natural product isolated and purified from the roots of Lithospermum ruderale with anti-HIV, anti-gonadotrophic and anti-thyroidal effects, and is a cardiotonic agent[3]. LSA (Lithospermic Acid) inhibited the formation of uric acid and superoxide radicals significantly with an IC50 5.2 and 1.08 mg/ml, respectively, and exhibited competitive inhibition. LSA scavenged superoxide radicals directly in the system beta-NADH/PMS and inhibited the production of superoxide in human neutrophils stimulated by PMA and fMLP. LSA also have hypouricemic activity on oxonate-pretreated rats in vivo and have anti-inflammatory effects in a model of gouty arthritis[4]. Lithospermic acid significantly attenuated the CCl4-induced oxidative damage in a concentration-dependent manner. Pretreatment of mice with lithospermic acid for six days significantly reduced CCl4-induced hepatic oxidative damage, serum AST (aspartate transaminase) and ALT(alanine transaminase). The pretreatment also increased SOD (superoxide dismutase) and CAT (catalase)[5]. Lithospermic acid possesses specific inhibitory effect on caspase 3[6]. Lithospermic acid attenuates mesenteric ischemia reperfusion injury in rat intestines by increasing tissue SOD and GPx (glutathione peroxidase) activities and decreasing MDA and MPO (myeloperoxidase) levels. Lithospermic acid also improves morphological alterations which occurred after periods of reperfusion[7]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.86mL 0.37mL 0.19mL |
9.29mL 1.86mL 0.93mL |
18.57mL 3.71mL 1.86mL |
CAS号 | 28831-65-4 |
分子式 | C27H22O12 |
分子量 | 538.46 |
SMILES Code | O=C([C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C(O)C=CC(/C=C/C(O[C@@H](C(O)=O)CC4=CC=C(O)C(O)=C4)=O)=C13)O |
MDL No. | MFCD03427311 |
别名 | Lithospermic Acid A; (+)-Lithospermic Acid |
运输 | 蓝冰 |
InChI Key | UJZQBMQZMKFSRV-RGKBJLTCSA-N |
Pubchem ID | 6441498 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere, 2-8°C |
溶解方案 |
请根据您的动物给药指南选择适当的溶解方案。 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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