There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Lintitript, also known as SR 27897, is a potent, selective, orally active, competitive non-peptide antagonist of the CCK1 receptor, with an EC50 of 6 nM and a Ki of 0.2 nM. Its selectivity for the CCK1 receptor is 33 times greater than that for the CCK2 receptor (EC50 of 200 nM). Lintitript increases plasma concentrations of leptin and food intake as well as insulin[1][2][3]. Lintitript antagonizes CCK-stimulated amylase release in isolated rat pancreatic acini (pA2 = 7.50) and CCK-induced contractions in guinea pig gall bladder (pA2 = 9.57). It inhibits the binding of [125I]CCK to CCK1 receptor sites in rat pancreas (IC50 = 0.58 nM) and to CCK2 sites in guinea pig cortex (IC50 = 479 nM) in a concentration-dependent manner. Lintitript also inhibits the binding of [125I]gastrin to gastrin receptors. At 0.5 nM, Lintitript increases the dissociation constant (Kd) for CCK from the CCK A receptor (Kd = 1.8 to 7.2 nM) without altering the maximum number of receptors (Bmax = 1800 to 1770 fmol/mg)[1].
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