LUT014
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货号：A1176803
LUT-014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and it is developed to reduce dose-limiting acneiform lesions associated EGFR inhibitors treatment.
LUT014 化学结构
LUT014 3D分子结构
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LUT014 纯度/质量文件 产品仅供科研
货号：A1176803
标准纯度：
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LUT014 质控信息
Encorafenib
✔
99%+
GDC-0879
++++
99%+
SB-590885
++++
99%+
RAF265
99%+
Dabrafenib
++++
B-Raf (V600E), IC50: 0.7 nM
B-Raf, IC50: 5.2 nM
+++
98%
Lifirafenib
++++
++
BRAF WT, IC50: 32 nM
BRAF(V600E), IC50: 23 nM
+++
C-RAF (Y340/341D), IC50: 7 nM
EGFR
98%
ZM 336372
+
99%+
NVP-BHG 712
+
99%+
CCT196969
+
++
Src
98%
Vemurafenib
++
B-Raf (V600E), IC50: 31 nM
B-Raf, IC50: 100 nM
+
98+%
PLX4720
++
B-Raf (V600E), IC50: 13 nM
B-Raf, IC50: 160 nM
+++
C-Raf-1 (Y340D/Y341D), IC50: 6.7 nM
BRK
99+%
GW 5074
+++
99%+
Avutometinib
+++
BRAF, IC50: 19 nM
BRAF V600E, IC50: 8.2 nM
+
98%
LY3009120
++++
BRAF WT, IC50: 15 nM
BRAF(V600E), IC50: 5.8 nM
++++
99%+
Agerafenib
++
B-Raf (V600E), Kd: 14 nM
B-Raf, Kd: 36 nM
+
RET
99%+
TAK-632
+++
++++
99%+
AZ 628
+
B-Raf (V600E), IC50: 34 nM
B-Raf, IC50: 105 nM
++
99%
PLX7904
✔
98+%
Sorafenib
++
B-Raf, IC50: 22 nM
B-Raf (V599E), IC50: 38 nM
++++
++++
99%
Tovorafenib
✔
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
LUT014 生物活性
描述
BRaf is a protein kinase involved in the regulation of the mitogen activated protein kinase (MAPK) signaling pathway. Mutations in BRaf can induce constitutive signaling through the MAPK pathway which may result in uncontrolled cell proliferation. LUT-014 is a BRaf inhibitor with an IC50 value of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated epidermal growth factor receptor (EGFR) Inhibitors treatment[1]
LUT014 参考文献
LUT014 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.89mL
0.38mL
0.19mL
9.46mL
1.89mL
0.95mL
18.92mL
3.78mL
1.89mL
LUT014 技术信息
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