LF3
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货号：A406788
LF3 is an inhibitor of canonical wnt signaling pathway with IC50 of less than 2 μM. It can disrupt the interaction between β-catenin and TCF4.
LF3 3D分子结构
规格
价格
会员价
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LF3 纯度/质量文件 产品仅供科研
货号：A406788
标准纯度：
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LF3 质控信息
LF3 生物活性
描述
LF3 inhibits Wnt/β-catenin signaling in cells with exogenous reporter genes and in colorectal cancer cells with high intrinsic Wnt activity, with IC50 values of 1.65 μM (β-Catenin/TCF4, AlphaScreen) and 1.82 μM (β-Catenin/TCF4, ELISA). LF3 also suppresses cancer cell traits associated with Wnt signaling, including high cell motility, cell cycle progression, and overexpression of Wnt target genes. However, LF3 does not induce cell death or interfere with cadherin-mediated cell adhesion. Notably, the self-renewal capacity of cancer stem cells is blocked by LF3 in a concentration-dependent manner[1]
LF3 动物研究
Dose
NOD/SCID Mice: 50 mg/kg[1]
Administration
i.v.
LF3 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT02683616
Obstructive Sleep Apnea
... 展开 >> Fatty Acid Metabolism
Continuous Positive Airway Pressure 收起 <<
Not Applicable
Recruiting
December 2019
Czechia
... 展开 >> FN Kralovske Vinohrady
Recruiting
Prague, Czechia, 10034
Contact: Jan Polak, MD, PhD +420267162710 jan.polak@lf3.cuni.cz
Contact: Jan Gojda, MD, PhD +420267168144 jan.gojda@lf3.cuni.cz 收起 <<
NCT03710850
Insulin Resistance
... 展开 >> Microbiome 收起 <<
Not Applicable
Recruiting
December 31, 2021
Czechia
... 展开 >> University Hospital Kralovske Vinohrady
Recruiting
Prague, Czechia, 10084
Contact: Jana Potočková +420267163031 klinicka.fyziologie@lf3.cuni.cz 收起 <<
NCT03386461
Metabolism Disorder
... 展开 >> Adiposity
Inflammatory Response 收起 <<
Not Applicable
Recruiting
December 2019
Czechia
... 展开 >> Third Faculty of Medicine, Charles University
Recruiting
Prague, Czechia, 100 00
Contact: Michaela Siklova, PhD +420 267 102 211 michaela.siklova@lf3.cuni.cz
Contact: Lenka Rossmeislova, PhD +420 267 102 211 lenka.rossmeislova@lf3.cuni.cz
Principal Investigator: Michaela Siklova, PhD
Sub-Investigator: Martin Rossmeisl, PhD
Sub-Investigator: Vladimir Stich, prof. MUDr. 收起 <<
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LF3 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.40mL
0.48mL
0.24mL
12.00mL
2.40mL
1.20mL
24.01mL
4.80mL
2.40mL
LF3 技术信息
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