L-cycloserine is an inhibitor of serine palmitoyltransferase and block sphingosine biosynthesis. It has antibiotic effective against mycobacterium tuberculosis.
L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease[3]. L-cycloserine injected subcutaneously in young mice have shown that cerebroside synthesis is inhibited specifically. It is also resulted in significant reduction in brain cerebroside level with low-dose injection for two month; liver and spleen glucocerebroside levels were also significantly reduced[4]. L-Cycloserine inhibited the activity of gamma-aminobutyric acid (GABA)-transaminase (GABA-T) and elevated the level of GABA in whole mouse brain with a peak effect 3-4 hr after injection. L-Cycloserine (10-30 mg/kg, p.o. or i.p.) prevented tonic seizures induced by 3-mercaptopropionic acid (3-MPA) and audiogenic seizures in DBA/2 mice. Similarly, small doses of L-cycloserine reduced the level of cGMP in the cerebellum of rats. Larger doses of L-cycloserine (greater than 30-100 mg/kg) impaired the performance of mice in the rotarod, chimney and horizontal wire tests, and reduced spontaneous locomotor activity of rats[5].
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