Kaempferol | Kempferol;Robigenin;Pelargidenolon;Indigo Yellow;Campherol;3,4',5,7-Tetrahydroxyflavone;Trifolitin;Swartziol;Rhamnolutein;Pelargidenon;NSC 656277;Nimbecetin;NSC 407289 | 山柰酚 | Plant Standard | ERR

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Kaempferol/山奈酚 {[allProObj[0].p_purity_real_show]}

货号：A272671 同义名： 山柰酚 / Kempferol; Robigenin

Kaempferol acts as an inverse agonist that directly binds ERRα and ERRγ. It is a natural flavonol with antitumor activity.

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Kaempferol/山奈酚化学结构
CAS号：520-18-3

Kaempferol/山奈酚 3D分子结构
CAS号：520-18-3

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Kaempferol/山奈酚纯度/质量文件产品仅供科研

货号：A272671 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Kaempferol/山奈酚生物活性

描述

ERR (Estrogen Related Receptor) is a group of nuclear receptors that is closely related to the estrogen receptor. The main isoforms of ERR are ERRα, ERRβ and ERRγ. ERRs act as a site-specific transcription regulator and have been also shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein contact. The binding and regulatory activities of ERRs have been demonstrated in the regulation of a variety of genes^[3]. Kaempferol is an inverse agonist of ERRα and ERRγ. Kaempferol dose-dependently inhibited ERRα and ERRγ activity at the concentrations of 5, 10, and 20 μM^[4]. Human cholangiocarcinoma (CCA) cells HCCC9810 or QBC939 were exposed to 30, 60, 90, 120 or 150 μM kaempferol. Kaempferol significantly inhibited the viability of CCA cells in a time and dose dependent way^[5]. Treatment to HepG2 cells by 10 μM kaempferol for 24h suppressed ERRα and ERRγ target genes PDK2 and PDK4^[4]. In a CCA QBC939 xenograft model established in nude mice, kaempferol was i.p. administrated daily at the dose of 20 mg/kg for 3 weeks. Kaempferol significantly inhibited tumor growth and the number of Ki-67 positive tumor cells was lower in kaempferol-treated group than that in the control group^[5]. In a BSA-challenged BALB/c mice model of asthma, oral administration of ≤20 mg/kg kaempferol blocked epithelial cell excrescence and smooth muscle hypertrophy^[6].

作用机制

Kaempferol directly binds the ligand binding domains (LBD) of ERRs.

Kaempferol/山奈酚细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
B16-4A5 cells		Function assay		Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs, IC50=20 μM	19615910
HEK293 FS cells		Function assay		Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=1.2 μM	20731357
human A549 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human A549 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
human BxPC3 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217

Kaempferol/山奈酚参考文献

[1]Wang J, Fang F, et al. Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist. FEBS Lett. 2009 Feb 18;583(4):643-7.

[2]Luo H, Jiang B, et al. Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability. Int J Nanomedicine. 2012;7:3951-9.

[3]Sladek R, Bader JA, Giguère V. The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol. 1997 Sep;17(9):5400-9. doi: 10.1128/MCB.17.9.5400. PMID: 9271417; PMCID: PMC232390.

[4]Wang J, Fang F, Huang Z, Wang Y, Wong C. Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist. FEBS Lett. 2009 Feb 18;583(4):643-7. doi: 10.1016/j.febslet.2009.01.030. Epub 2009 Jan 24. PMID: 19171140.

[5]Qin Y, Cui W, Yang X, Tong B. Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2016 Mar;48(3):238-45. doi: 10.1093/abbs/gmv133. Epub 2016 Feb 15. PMID: 26883800; PMCID: PMC4885126.

[6]Shin D, Park SH, Choi YJ, Kim YH, Antika LD, Habibah NU, Kang MK, Kang YH. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16(12):29980-95. doi: 10.3390/ijms161226218. PMID: 26694364; PMCID: PMC4691161.

Kaempferol/山奈酚实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

1.75mL

34.94mL

6.99mL

3.49mL

Kaempferol/山奈酚技术信息

CAS号	520-18-3
分子式	C₁₅H₁₀O₆
分子量	286.24
SMILES Code	O=C(C1=C(O)C=C(O)C=C1O2)C(O)=C2C3=CC=C(O)C=C3
MDL No.	MFCD00016938

别名	山柰酚 ;Kempferol; Robigenin; Pelargidenolon; Indigo Yellow; Campherol; 3,4',5,7-Tetrahydroxyflavone; Trifolitin; Swartziol; Rhamnolutein; Pelargidenon; NSC 656277; Nimbecetin; NSC 407289
运输	蓝冰
InChI Key	IYRMWMYZSQPJKC-UHFFFAOYSA-N
Pubchem ID	5280863

存储条件	In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, inert atmosphere, room temperature

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

B16-4A5 cells		Function assay		Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs, IC50=20 μM	19615910
HEK293 FS cells		Function assay		Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=1.2 μM	20731357
human A549 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human A549 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
human BxPC3 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
human HeLa cells		Function assay		Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay, Ki=2.4 μM	19725578
human HL60 cells		Cytotoxicity assay		Cytotoxicity against human HL60 cells assessed as cell survival at 50 uM after 72 hrs by CCK8 assay	25074815
human MCF7 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
human MDA-kb2 cells		Function assay		Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene assay, IC50=9.7 μM	19592245
human MV4-11 cells		Cytotoxicity assay	72 h	Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay, GI50=3.34 μM	23411073
human NCI-H2126 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human NCI-H2126 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
human PANC1 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
human SMMC7721 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
human U87 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human U87 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
MDA-MB-231 cells	5-40 μM	Cytotoxicity assay	72 h	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay	22871217
MDCK cells		Function assay		Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining, IC50=4.7 μM	21354800
MDCK cells	50 μM	Function assay		Antiviral activity against influenza A virus H1N1 A/PR/8/34 infected in MDCK cells assessed as reduction in fluorescence positive cells at 50 uM immunofluorescence assay	19729316
mouse 3T3L1 cells		Function assay		Inhibition of AMPK-mediated adipocyte differentiation in mouse 3T3L1 cells	20822902
mouse L929 cells		Function assay		Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment	9287415
mouse RAW264.7 cells		Function assay		Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as nitrite level at 1 to 100 uM after 24 hrs by Griess method	21353543

Kaempferol/山奈酚 {[allProObj[0].p_purity_real_show]}

Kaempferol/山奈酚纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Kaempferol/山奈酚质控信息

Kaempferol/山奈酚生物活性

Kaempferol/山奈酚细胞研究

Kaempferol/山奈酚参考文献

Kaempferol/山奈酚实验方案

Kaempferol/山奈酚技术信息

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全球学术期刊中引用的产品

Kaempferol/山奈酚 质控信息

Kaempferol/山奈酚 生物活性

Kaempferol/山奈酚 细胞研究

Kaempferol/山奈酚 参考文献

Kaempferol/山奈酚 实验方案

Kaempferol/山奈酚 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Kaempferol/山奈酚纯度/质量文件产品仅供科研

Kaempferol/山奈酚质控信息

Kaempferol/山奈酚生物活性

Kaempferol/山奈酚细胞研究

Kaempferol/山奈酚参考文献

Kaempferol/山奈酚实验方案

Kaempferol/山奈酚技术信息