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/ Isoquercetin/槲皮素 3-β-D-葡萄糖甙

Isoquercetin/槲皮素 3-β-D-葡萄糖甙 {[allProObj[0].p_purity_real_show]}

货号：A678611 同义名： 槲皮素-3-葡萄糖苷 / Quercetin 3-glucoside; NSC 115918

Isoquercitrinis can inhibit Wnt/β-catenin and activate the mitogen-activated protein kinase (MAPK) signalling pathway. It is a natural product isolated and purified from the herbs of Prunella vulgaris L. with a good effect of expectorant, cough, asthma and anti-tumoral activity.

Isoquercetin/槲皮素 3-β-D-葡萄糖甙 化学结构 CAS号：482-35-9
Isoquercetin/槲皮素 3-β-D-葡萄糖甙 化学结构
CAS号：482-35-9
Isoquercetin/槲皮素 3-β-D-葡萄糖甙 3D分子结构
CAS号：482-35-9
Isoquercetin/槲皮素 3-β-D-葡萄糖甙 化学结构 CAS号：482-35-9
Isoquercetin/槲皮素 3-β-D-葡萄糖甙 3D分子结构 CAS号：482-35-9
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Isoquercetin/槲皮素 3-β-D-葡萄糖甙 纯度/质量文件 产品仅供科研

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Isoquercetin/槲皮素 3-β-D-葡萄糖甙 生物活性

描述 Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor. Isoquercitrin reduced the depletion of glutathione (GSH) caused by elevation of specific radical species (H(2)O(2), OH* and O(2)(*-)) in RGC-5 cells in culture and blunted the decrease in catalase and glutathione peroxidase 1 (Gpx-1) caused by exposure of RGC-5 cells to H(2)O(2). Furthermore, isoquercitrin potently attenuated the lipid peroxidation of rat brain homogenates initiated by nitric oxide, with an IC(50) value of 1.04 μM[3]. Isoquercitrin (20 mg/kg/day) treatment achieved significantly higher SFI and higher amplitude of CMAP, promoted the nerve regeneration and remyelination, increased the production of GAP43, NF200, MAG and PMP22, alleviated target muscle atrophy and autophagy, and suppressed the expression of ATG7, PINK1 and Beclin1 in soleus muscles after sciatic nerve crush. The administration of isoquercitrin at 40 and 320 µM showed a dose dependent, and high doses of isoquercitrin (160 and 320 µM) showed better performance in promoting axonal regeneration of DRGs neurons, and the proliferation and migration of Schwann cells than low dose of isoquercitrin (40 µM)[4]. The cell proliferation of osteoblasts and BMSCs was promoted by isoquercitrin at low concentrations. High concentrations of isoquercitrin promoted the osteogenic differentiation via RUNX2 expression in osteoblasts and via the bone morphogenetic protein (BMP) pathway in BMSCs[5]. Quercetin and isoquercitrin inhibit gluconeogenesis in hepatocytes, which may be related to the LKB1 upregulation and phosphorylation of AMPKα[6].

Isoquercetin/槲皮素 3-β-D-葡萄糖甙 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01691404 Hypertension ... 展开 >>Endothelial Dysfunction 收起 << Not Applicable Completed - Netherlands ... 展开 >> Wageningen University Wageningen, Netherlands, 6703 HD 收起 <<
NCT02195232 Thromboembolism of Vein VTE in... 展开 >> Colorectal Cancer Thromboembolism of Vein in Pancreatic Cancer Thromboembolism of Vein in Non-small Cell Lung Cancer 收起 << Phase 2 Phase 3 Recruiting April 2023 United States, California ... 展开 >> USC/Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Howard Liebman, MD    323-865-0579    Liebman_h@med.usc.edu    Principal Investigator: Howard Liebman, MD          VA Northern California Health Care System Recruiting Sacramento, California, United States, 95655 Contact: Theodore Wun, MD    916-734-1507    Twun@ucdavis.edu    Principal Investigator: Theodore Wun, MD          United States, Connecticut VA Connecticut Healthcare System Recruiting West Haven, Connecticut, United States, 06450 Contact: Ellice Wong, MD    203-937-3421    Ellice.wong@va.gov    Principal Investigator: Ellice Wong, MD          United States, District of Columbia Veterans Affair Medical Center Recruiting Washington, District of Columbia, United States, 20422 Contact: Anita Aggarwal, DO, PhD    202-745-8000    anita.aggarwal@va.gov    Principal Investigator: Anita Aggarwal, DO, PhD          United States, Maine York Hospital-Oncology Treatment Center Recruiting York, Maine, United States, 03909 Contact: Marilyn D. McLaughlin, MD    207-351-3777    Mmclaughlin@yorkhospital.com    Principal Investigator: Marilyn D. McLaughlin, MD          United States, Massachusetts Boston VA Healthcare System Recruiting Boston, Massachusetts, United States, 02130 Contact: Kenneth Bauer, MD    857-364-5033    kenneth.bauer@va.gov    Principal Investigator: Kenneth A. Bauer, MD          Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: Jeffrey Zwicker, MD    617-667-9299    jzwicker@bidmc.harvard.edu    Principal Investigator: Jeffrey Zwicker, MD          Mount Auburn Hospital Recruiting Waltham, Massachusetts, United States, 02138 Contact: Thomas Caughey, MD    617-497-9646    tcaughey@mah.harvard.edu    Principal Investigator: Thomas Caughey, MD          United States, Missouri Washington University in St. Louis Recruiting Saint Louis, Missouri, United States, 63110 Contact: Kristen Sanfilippo, MD    314-362-0233    ksanfilippo@wustl.edu    Principal Investigator: Kristen Sanfilippo, MD          United States, Rhode Island Providence VA Medical Center Recruiting Providence, Rhode Island, United States, 02908 Contact: Katherine Faricy-Anderson, MD    401-732-7100 ext 6158    Katherine.faricy-anderson@va.gov    Principal Investigator: Katherine Faricy-Anderson, MD          United States, Vermont White River Junction VA Medical Center Recruiting White River Junction, Vermont, United States, 05009 Contact: Nancy Kuemmerle, DO, PhD    802-295-9363    Nancy.Kuemmerle@va.gov    Principal Investigator: Nancy Kuemmerle, DO, PhD 收起 <<
NCT02818699 Overweight Ob... 展开 >>ese 收起 << Not Applicable Recruiting January 2018 United States, Massachusetts ... 展开 >> Human Nutrition Research Center on Aging at Tufts University Recruiting Boston, Massachusetts, United States, 02111 收起 <<

Isoquercetin/槲皮素 3-β-D-葡萄糖甙 参考文献

[1]Chen Q, Li P, et al. Isoquercitrin inhibits the progression of pancreatic cancer in vivo and in vitro by regulating opioid receptors and the mitogen-activated protein kinase signalling pathway. Oncol Rep. 2015 Feb;33(2):840-8.

[2]Wang X, Schroder HC, et al. Isoquercitrin and polyphosphate co-enhance mineralization of human osteoblast-like SaOS-2 cells via separate activation of two RUNX2 cofactors AFT6 and Ets1. Biochem Pharmacol. 2014 Jun 1;89(3):413-21.

[3]Jung SH, Kim BJ, Lee EH, Osborne NN. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21

[4]Qiu J, Yang X, Wang L, Zhang Q, Ma W, Huang Z, Bao Y, Zhong L, Sun H, Ding F. Isoquercitrin promotes peripheral nerve regeneration through inhibiting oxidative stress following sciatic crush injury in mice. Ann Transl Med. 2019 Nov;7(22):680

[5]Li M, Zhang C, Li X, Lv Z, Chen Y, Zhao J. Isoquercitrin promotes the osteogenic differentiation of osteoblasts and BMSCs via the RUNX2 or BMP pathway. Connect Tissue Res. 2019 Mar;60(2):189-199

[6]Chen L, Shen T, Zhang CP, Xu BL, Qiu YY, Xie XY, Wang Q, Lei T. Quercetin and Isoquercitrin Inhibiting Hepatic Gluconeogenesis Through LKB1-AMPKα Pathway. Acta Endocrinol (Buchar). 2020 Jan-Mar;16(1):9-14

Isoquercetin/槲皮素 3-β-D-葡萄糖甙 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.77mL

2.15mL

1.08mL

21.53mL

4.31mL

2.15mL

Isoquercetin/槲皮素 3-β-D-葡萄糖甙 技术信息

CAS号482-35-9
分子式C21H20O12
分子量 464.38
SMILES Code O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)=C(C3=CC=C(O)C(O)=C3)OC4=C1C(O)=CC(O)=C4
MDL No. MFCD00017746
别名 槲皮素-3-葡萄糖苷 ;Quercetin 3-glucoside; NSC 115918; Quercetin 3-O-glucoside; Quercetin 3-β-D-glucoside; Quercetin 3-o-glucopyranoside; 3-Glucosylquercetin; Hirsutrin
运输蓝冰
InChI Key OVSQVDMCBVZWGM-QSOFNFLRSA-N
Pubchem ID 5280804
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Isoquercetin | Quercetin 3-glucoside;NSC 115918;Quercetin 3-O-glucoside;Quercetin 3-β-D-glucoside;Quercetin 3-o-glucopyranoside;3-Glucosylquercetin;Hirsutrin;Isoquercitrin | 槲皮素-3-葡萄糖苷 | Plant Standard | Wnt | AmBeed-信号通路专用抑制剂 | Isoquercetin/槲皮素 3-β-D-葡萄糖甙 纯度/质量文件 | Isoquercetin/槲皮素 3-β-D-葡萄糖甙 生物活性 | Isoquercetin/槲皮素 3-β-D-葡萄糖甙 临床数据 | Isoquercetin/槲皮素 3-β-D-葡萄糖甙 参考文献 | Isoquercetin/槲皮素 3-β-D-葡萄糖甙 实验方案 | Isoquercetin/槲皮素 3-β-D-葡萄糖甙 技术信息

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