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Isoconazole nitrate/硝酸异康唑 {[allProObj[0].p_purity_real_show]}

货号:A113906 同义名: Isoconazole (nitrate); R 15454

Isoconazole Nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity and is effective in the treatment of dermatomycoses.

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Isoconazole nitrate/硝酸异康唑 化学结构 CAS号:24168-96-5
Isoconazole nitrate/硝酸异康唑 化学结构
CAS号:24168-96-5
Isoconazole nitrate/硝酸异康唑 3D分子结构
CAS号:24168-96-5
Isoconazole nitrate/硝酸异康唑 化学结构 CAS号:24168-96-5
Isoconazole nitrate/硝酸异康唑 3D分子结构 CAS号:24168-96-5
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Isoconazole nitrate/硝酸异康唑 纯度/质量文件 产品仅供科研

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Isoconazole nitrate/硝酸异康唑 生物活性

描述 Isoconazole nitrate (ISN) is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, a rapid rate of absorption and low systemic exposure potential. ISN is effective against pathogens involved in dermatomycoses, with minimum inhibitory concentrations well below the concentration of ISN in skin and hair follicles[3]. Treatment results with the combination of isoconazole nitrate and diflucortolone valerate were superior regarding erythema and pruritus[4]. 1% isoconazole nitrat is more effective than a commercial cream containing 1% clotrimazole[5].

Isoconazole nitrate/硝酸异康唑 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00722189 - Completed - Russian Federation ... 展开 >> Kashkin Clinical Research Mycological Institute St Petersburg, Russian Federation 收起 <<

Isoconazole nitrate/硝酸异康唑 参考文献

[1]Bianchi L, Hansel K, et al. Contact allergy to isoconazole nitrate with unusual spreading over extensive regions. Contact Dermatitis. 2017 Apr;76(4):243-245.

[2]Czaika VA, Siebenbrock J, et al. Reactive oxygen species and the bacteriostatic and bactericidal effects of isoconazole nitrate. Mycoses. 2013 May;56 Suppl 1:16-22.

[3]Veraldi S. Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Mycoses. 2013;56 Suppl 1:3–15.

[4]Veraldi S, Persico MC, Schianchi R. Isoconazole nitrate vs isoconazole nitrate and diflucortolone valerate in the treatment of tinea inguinalis: results of a multicenter retrospective study. J Drugs Dermatol. 2012;11(11):e70–e73.

[5]Wendt H, Kessler J. Antimikrobielle Wirksamkeit des Breitspektrum-Antimykotikums Isoconazolnitrat im Humanversuch [Antimicrobial activity of the broad spectrum antimycotic isoconazole nitrate in humans (author's transl)]. Arzneimittelforschung. 1979;29(5):846–848.

Isoconazole nitrate/硝酸异康唑 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.44mL

2.09mL

1.04mL

20.87mL

4.17mL

2.09mL

Isoconazole nitrate/硝酸异康唑 技术信息

CAS号24168-96-5
分子式C18H15Cl4N3O4
分子量 479.14
SMILES Code ClC1=C(COC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C(Cl)=CC=C1.O[N+]([O-])=O
MDL No. MFCD01721647
别名 Isoconazole (nitrate); R 15454; Adestan G 100
运输蓝冰
InChI Key NNGQLSIGRSTLLU-UHFFFAOYSA-N
Pubchem ID 159968
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, room temperature

溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
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