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Ipragliflozin/伊格列净 {[allProObj[0].p_purity_real_show]}

货号:A136380 同义名: ASP1941

Ipragliflozin is a selective inhibitor of SGLT2 with IC50 of 14 nM for hSGLT2.

Ipragliflozin/伊格列净 化学结构 CAS号:761423-87-4
Ipragliflozin/伊格列净 化学结构
CAS号:761423-87-4
Ipragliflozin/伊格列净 3D分子结构
CAS号:761423-87-4
Ipragliflozin/伊格列净 化学结构 CAS号:761423-87-4
Ipragliflozin/伊格列净 3D分子结构 CAS号:761423-87-4
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Ipragliflozin/伊格列净 纯度/质量文件 产品仅供科研

货号:A136380 标准纯度: {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

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产品名称 SGLT1 SGLT2 其他靶点 纯度
Phloretin 98%
Canagliflozin +++

mSGLT2, IC50: 2 nM

hSGLT2, IC50: 3.7 nM

95%
Empagliflozin ++

SGLT2, IC50: 3.1 nM

98%
Dapagliflozin ++++

hSGLT2, EC50: 1.1 nM

97%
Tofogliflozin (hydrate) +++

hSGLT2, IC50: 2.9 nM

99%+
Sotagliflozin +

SGLT1, IC50: 36 nM

++++

SGLT2, IC50: 1.8 nM

98%
Ipragliflozin ++

hSGLT2, IC50: 7.4 nM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Ipragliflozin/伊格列净 生物活性

靶点
  • SGLT2

    hSGLT2, IC50:7.4 nM

  • SGLT2

    hSGLT2, IC50:7.4 nM

描述 Ipragliflozin (ASP1941) is an orally active and selective inhibitor of SGLT2, with IC50s of 7.38 and 1876 nM for human SGLT2 and SGLT1, respectively. It serves as an antidiabetic agent[1].

Ipragliflozin/伊格列净 动物研究

Animal study Ipragliflozin exhibits antihyperglycemic effects, with dose-dependent inhibition of increases in blood glucose levels. In both STZ-induced type 1 diabetic rats and KK-Ay type 2 diabetic mice, this effect is significant at various tested doses[1].In streptozotocin-induced type 1 diabetic rats, repeated administration of Ipragliflozin (0.3 and 1 mg/kg) demonstrates antidiabetic effects[1].In Streptozotocin (STZ; 50 mg/kg)-induced type 1 diabetic rats and KK-Ay type 2 diabetic mice, doses ranging from 0.1 to 1 mg/kg were orally administered once in the fed state. Blood glucose levels were then monitored for 8 hours under fasting conditions. The results indicated a dose-dependent reduction in blood glucose levels, which was statistically significant at all tested doses. This experiment utilized a repeated administration animal model[1].In Streptozotocin (STZ; 50 mg/kg)-induced type 1 diabetic rats, doses of 0.3 and 1 mg/kg were orally administered once daily at night for 4 weeks. The outcome revealed significant reductions in both HbA1c and blood glucose levels. Furthermore, pancreatic insulin content significantly increased at a dose of 1 mg/kg. Urinary glucose excretion exhibited a dose-dependent increase, reaching significance at the 1 mg/kg dose[1].

Ipragliflozin/伊格列净 参考文献

[1]Atsuo Tahara, et al. Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2012 Apr;385(4):423-36.

[2]Shiho Komatsu, et al. SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation. Endocr J. 2020 Jan 28;67(1):99-106.

Ipragliflozin/伊格列净 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.36mL

2.47mL

1.24mL

24.72mL

4.94mL

2.47mL

Ipragliflozin/伊格列净 技术信息

CAS号761423-87-4
分子式C21H21FO5S
分子量 404.45
SMILES Code O[C@H]1[C@H](C2=CC=C(F)C(CC3=CC4=CC=CC=C4S3)=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
MDL No. MFCD19443744
别名 ASP1941
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, sealed in dry, 2-8°C

溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
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