Inositol nicotinate is a form of niacin, also known as vitamin B3, which is an essential nutrient for the human body. Inositol nicotinate has the effect of lowering cholesterol and dilating peripheral blood vessels. It is used in hypercholesterolemia and atherosclerosis. The thermographic index for both the dorsum of the hand and the fingers was significantly lower in the patients with Raynaud's. Oral treatment with inositol nicotinate (Hexopal) was followed by an initial rise in the thermographic index in both areas. Long-term treatment with nicotinate acid derivatives may produce improvement in the peripheral circulation by a different mechanism than the transient effect detected by short-term studies[1]. Recording the time required to induce Raynaud's phenomenon as well as assessments of total and nutrient digital blood flow showed significant beneficial therapeutic effects upon the skin's microcirculation by inositol nicotinate. Unlike some other drugs in this field inositol nicotinate was found to be effective orally and to be devoid of unwanted side-effects[2].
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