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Imazalil/抑霉唑 {[allProObj[0].p_purity_real_show]}

货号:A103271 同义名: Enilconazole; (±)-Imazalil

Imazalil is the most commonly used fungicide in postharvest fungicide in citrus.

Imazalil/抑霉唑 化学结构 CAS号:35554-44-0
Imazalil/抑霉唑 化学结构
CAS号:35554-44-0
Imazalil/抑霉唑 3D分子结构
CAS号:35554-44-0
Imazalil/抑霉唑 化学结构 CAS号:35554-44-0
Imazalil/抑霉唑 3D分子结构 CAS号:35554-44-0
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Imazalil/抑霉唑 纯度/质量文件 产品仅供科研

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Imazalil/抑霉唑 生物活性

描述 Imazalil is a widely used chiral fungicide. The fungicide imazalil is a chiral compound with one R- and one S-enantiomer. Imazalil have been shown to synergize the effect of pyrethroid insecticides like α-cypermethrin through inhibition of cytochrome P450 monooxygenase responsible for pyrethroid detoxification. The R- and S-imazalil enantiomers increased α-cypermethrin toxicity from an EC50 of 1580 ± 980 pmol/L to an EC50 of 83 ± 10 pmol/L and 53 ± 8 pmol/L, respectively[3]. However, R-(-)-imazalil was 1.21 times more toxic than S-(+)-imazalil to D. rerio. High-effective S-(+)-imazalil preferentially enriched in leaf and fruit of tomato and cucumber, and no enantioselective degradation was found in soil[4]. Imazalil can accumulate in the body and threaten an animal's health. And Imazalil induced oxidative stress and caused the disorders of bile acid metabolism in mice. Chronic Imazalil exposure could induce hepatotoxicity in mice at the physiological, biochemical, and transcriptome levels[5].

Imazalil/抑霉唑 参考文献

[1]Sun X, Ruan R, et al. Genomewide investigation into DNA elements and ABC transporters involved in imazalil resistance in Penicillium digitatum. FEMS Microbiol Lett. 2013 Nov;348(1):11-8.

[2]Thienpont D, Van Cutsem J, et al. The biological and toxicological properties of imazalil. Arzneimittelforschung. 1981;31(2):309-15.

[3]Kuhlmann J, Kretschmann AC, Bester K, Bollmann UE, Dalhoff K, Cedergreen N. Enantioselective mixture toxicity of the azole fungicide imazalil with the insecticide α-cypermethrin in Chironomus riparius: Investigating the importance of toxicokinetics and enzyme interactions. Chemosphere. 2019 Jun;225:166-173

[4]Li R, Pan X, Tao Y, Jiang D, Chen Z, Dong F, Xu J, Liu X, Wu X, Zheng Y. Systematic Evaluation of Chiral Fungicide Imazalil and Its Major Metabolite R14821 (Imazalil-M): Stability of Enantiomers, Enantioselective Bioactivity, Aquatic Toxicity, and Dissipation in Greenhouse Vegetables and Soil. J Agric Food Chem. 2019 Oct 16;67(41):11331-11339

[5]Jin C, Luo T, Fu Z, Jin Y. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33(6):650-658

Imazalil/抑霉唑 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.82mL

3.36mL

1.68mL

33.65mL

6.73mL

3.36mL

Imazalil/抑霉唑 技术信息

CAS号35554-44-0
分子式C14H14Cl2N2O
分子量 297.18
SMILES Code C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2
MDL No. MFCD00055331
别名 Enilconazole; (±)-Imazalil; Chloramizol; 1-(2-(2,4-Dichlorophenyl)-2-(2-propenyloxy)ethyl)-1H-imidazole
运输蓝冰
InChI Key PZBPKYOVPCNPJY-UHFFFAOYSA-N
Pubchem ID 37175
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

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