Helicid (Helicide) is a major constituent of Helicia nilgirica Bedd. Helicid has been used to treat psychoneurosis for its sedative-hypnotic and analgesic properties.
Helicid (Helicide) is a major constituent of Helicia nilgirica Bedd. Helicid has been used to treat psychoneurosis for its sedative-hypnotic and analgesic properties. Helicid significantly regulated levels of corticosterone (CORT), inflammatory cytokines and 5-hydroxytryptamine (5-HT). Helicid also reversed CUMS-induced decreases of 5-HT1A receptor expression and promoted brain derived neurotrophic factor (BDNF) expression in the hippocampus. The significant reversal of depressive-like behaviors by helicid is similar to that achieved by fluoxetine[2]. Helicid is an effective agent for both neuropathic pain and sleep disturbances in partial sciatic nerve ligated mice. Immunohistochemical study showed that helicid (400 mg/kg ) administration could reverse the increase of c-Fos expression in the neurons of the rostral anterior cingulate cortex and tuberomammillary nucleus, and the decrease of c-Fos expression in the ventrolateral preoptic area caused by partial sciatic nerve ligation[3]. Helicid could improve depressive behaviors, learning and cognitive deficits and increase hippocampal neurogenesis, which may be mediated by the regulation of SERTs(serotonin transporters), activation of the cAMP/PKA/CREB signaling pathway and upregulation of p-CREB (cAMP response element-binding) levels in hippocampal[4].
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