HQNO
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货号：A1209614
同义名：
KF8940; 2-heptyl-4-hydroxyquinoline-N-oxide
HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa . It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.
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HQNO 纯度/质量文件 产品仅供科研
货号：A1209614
标准纯度：
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HQNO 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132C-IDH1, IC50: 0.16 μM
R132H-IDH1, IC50: 70 nM
99%+
SW033291
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
99%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase II, IC50: 27 nM
Inosine monophosphate dehydrogenase I, IC50: 39 nM
98%
MK-8245
++++
SCD1 (rat), IC50: 3 nM
SCD1 (mouse), IC50: 1 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
HQNO 生物活性
描述
Type II NADH: quinone oxidoreductase (NDH-2) is a membrane-bound bi-substrate enzyme that catalyses the cytoplasmic oxidation of NADH and reduction of quinone in the membrane. HQNO is a potent mitochondrial NDH-2 inhibitor in many species. Wide type NDH-2 had an IC50 value of 10.5 ± 1.3 μM HQNO in the presence of 400 μM menadione (MD). In the presence of 50 μM MD, the IC50 value for HQNO decreased slightly to 7.3 ± 1.2 μM and near complete inhibition was observed with > 50 μM HQNO[1]
作用机制
HQNO is nested into the slot-shaped tunnel of the Q-site, in which the quinone-head group is clamped by Q317 and I379 residues, and hydrogen-bonds to FAD[1]
HQNO 参考文献
HQNO 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.86mL
0.77mL
0.39mL
19.28mL
3.86mL
1.93mL
38.56mL
7.71mL
3.86mL
HQNO 技术信息
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